Search results for "structural"
showing 10 items of 5047 documents
Human Papillomavirus Type 16 E7 Peptide-Directed CD8+ T Cells from Patients with Cervical Cancer Are Cross-Reactive with the Coronavirus NS2 Protein
2003
ABSTRACTHuman papillomavirus type 16 (HPV16) E6 and E7 oncoproteins are required for cellular transformation and represent candidate targets for HPV-specific and major histocompatibility complex class I-restricted CD8+-T-cell responses in patients with cervical cancer. Recent evidence suggests that cross-reactivity represents the inherent nature of the T-cell repertoire. We identified HLA-A2 binding HPV16 E7 variant peptides from human, bacterial, or viral origin which are able to drive CD8+-T-cell responses directed against wild-type HPV16 E7 amino acid 11 to 19/20 (E711-19/20) epitope YMLDLQPET(T) in vitro. CD8+T cells reacting to the HLA-A2-presented peptide from HPV16 E711-19(20)recogni…
Revolutionary Struggle for Existence: Introduction to Four Intriguing Puzzles in Virus Research
2012
Cellular life is immersed into an ocean of viruses. Virosphere forms the shadow of this cell-based tree of life: completely dependent on the tree for existence, yet, the tree is equally unable to escape its ever evolving companion. How important role has the shadow played in the evolution of life? Is it a mere ethereal partner or a constitutive factor? In this chapter four puzzles in virus research are taken under the scope in order to probe some of the intriguing ways by which viruses can help us understand life on Earth. These puzzles consider the origin of genetic information in viruses, viruses as symbiotic partners, the structural diversity of viruses and the role of viruses in the ori…
Molecular Basis of SARS-CoV-2 Nsp1-Induced Immune Translational Shutdown as Revealed by All-Atom Simulations.
2021
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic represents the most severe global health crisis in modern human history. One of the major SARS-CoV-2 virulence factors is nonstructural protein 1 (Nsp1), which, outcompeting with the binding of host mRNA to the human ribosome, triggers a translation shutdown of the host immune system. Here, microsecond-long all-atom simulations of the C-terminal portion of the SARS-CoV-2/SARS-CoV Nsp1 in complex with the 40S ribosome disclose that SARS-CoV-2 Nsp1 has evolved from its SARS-CoV ortholog to more effectively hijack the ribosome by undergoing a critical switch of Q/E158 and E/Q159 residues that perfects Nsp1's interactions…
On the Dynamics of Fractional Visco-Elastic Beams
2012
With increasing advanced manufacturing process, visco-elastic materials are very attractive for mitigation of vibrations, provided that you may have advanced studies for capturing the realistic behavior of such materials. Experimental verification of the visco-elastic behavior is limited to some well-known low order models as the Maxwell or Kelvin models. However, both models are not sufficient to model the visco-elastic behavior of real materials, since only the Maxwell type can capture the relaxation tests and the Kelvin the creep tests, respectively. Very recently, it has been stressed that the most suitable model for capturing the visco-elastic behavior is the spring-pot, characterized …
Structural Equation Modeling in Research on Brand Capital in Higher Education
2016
This research is done in order to examine the role of the brand capital in higher education. For this purpose, we analyze the main contributions of the literature related to the study of the brand capital and its application in the educational sector, identifying which variables determine the brand capital in the higher education sector. Once we establish the susceptible brand capital in the higher education sector, an empirical research is done by using a questionnaire developed in Spanish language with a Likert scale of grade 5 in which 1 point means "strongly disagree" and 5 mean "strongly agree", being based on the measurement scales…
Upside-down ship’s kel-shaped vaults as a contemporary design criteria. The case of the Palace of the Dukes of Braganza in Guimarães (Portugal)
2015
A contemporary worldwide trend is exposing the structural elements of a building to create an articulate and complex architecture whose lines of force give robustness, stability and, at the same time, a sort of lightness and frivolity to the entire construction. However, the combination between the visual conception of architecture and the principles of statics is not new to the world of construction. Exposed structure as a design approach may be observed in many historical buildings, either public, religious or private, and in several cultural and geographical areas where exposed structures communicate power, solidity, and rigour along with an instance of economy and lightness. In this wor…
Assessment of Occupational Health and Job Satisfaction in Workers with Intellectual Disability: A Job Demands–Resources Perspective
2021
In the contexts where people with intellectual disability work, there are factors that determine their job satisfaction. The objective of this study was to test the adequacy of the central assumptions of the Job Demands–Resources (JD-R) theory in workers with intellectual disability employed in different work alternatives. Data from 362 workers in sheltered workshops and 192 workers in supported employment were utilized. The model was contrasted using a structural equation model and a multi-group analysis. The results supported the suitability of the model and confirmed that job demands and job resources evoke two relatively independent processes such as health impairment and motivational p…
The Effect of Emotional Dissonance and Mental Load on Need for Recovery and Work Engagement among Italian Fixed-Term Researchers
2020
Although many studies have been conducted to evaluate the risk and protective factors on psychological health among academic staff, little attention has been paid to fixed-term researchers, the weakest figures in the academic context. By using the Job Demands&ndash
Inspiriting Innovation: The Effects of Leader-Member Exchange (LMX) on Innovative Behavior as Mediated by Mindfulness and Work Engagement
2021
Continuous innovation has become a key to gaining a sustainable competitive advantage for organizations in the 21st century. By focusing on the underlying mechanisms (i.e., mindfulness and work engagement) by which it works, this study addresses the quality of leader–member relationships and their relevance for innovation in the workplace. Using a sample of 210 employees from 17 Spanish companies, a two-wave longitudinal design evaluated the mediational roles of mindfulness and engagement between leader–member exchange (LMX) quality and innovative work behavior (IWB) in an organizational context. Over the course of a year, two questionnaires were administered to measure LMX quality, mindful…
Differential effects of workaholism and work engagement on the interference between life and work domains
2018
This study analyzed the differences between workaholism and work engagement in relation to their influence on work–life interference. Workaholism is an addiction to work, characterized by obsessive attitude towards job, whereas work engagement concerns a positive pattern of thoughts and feelings about one’s job; these two constructs thus represent pathological and healthy forms of heavy work investment, respectively. As a consequence, it was expected that workaholism and work engagement would have different effects on perceived interference between work and life domains. We assessed levels of workaholism, work engagement, work-to-life interference, and life-to-work interference in a sample …