Search results for "structures"
showing 10 items of 4815 documents
Sedimentological and deformational criteria for discriminating subglaciofluvial deposits from subaqueous ice-contact fan deposits: A Pleistocene exam…
2014
A pit located near Ballyhorsey, 28 km south of Dublin (eastern Ireland), displays subglacially deposited glaciofluvial sediments passing upwards into proglacial subaqueous ice-contact fan deposits. The coexistence of these two different depositional environments at the same location will help with differentiation between two very similar and easily confused glacial lithofacies. The lowermost sediments show aggrading subglacial deposits indicating a constrained accommodation space, mainly controlled by the position of an overlying ice roof during ice-bed decoupling. These sediments are characterized by vertically stacked tills with large lenses of tabular to channelized sorted sediments. The…
Voxel-Based Morphomerty study in patients with amnestic Mild Cognitive Impairment and Alzheimer's Disease: population-based data from the Zabùt Aging…
2017
Aims and objectives Methods and materials Results Conclusion Personal information References
Seismic assessment and retrofit of a concrete building highly damaged by reinforcement corrosion
2020
In existing concrete structures damaged by corrosion, the limited quantity and poor distribution of reinforcements as well as a lack of seismic details are common to many cases because they are built before the advent of seismic codes. In this paper the seismic assessment and retrofit of a concrete building sited in Sicily is presented in order to show a case-study of a corroded reinforced concrete structure to be trans-formed with new structural elements for functional reasons linked to Civil Protection. After many decades of complete abandonment, the structure was strengthened with different strategies, allied to the construction of new steel-concrete composite floors: concrete and steel …
Effectiveness of isolated vertical extension of masonry buildings as nonconventional TMD
2023
In this paper, the strategy of Intermediate Isolation System (IIS) is proposed for the vertical extension of an aggregate of masonry buildings located in Pozzuoli, south Italy. The effectiveness of IIS working as a nonconventional Tuned Mass Damper (TMD) for the existing construction is assessed in terms of reduction of seismic demand and damage in the masonry structure undergoing inelastic deformation under seismic input. For this aim, a general step-by-step procedure is first defined and then applied to the case study building. In particular, the characterization of dynamic behaviour and seismic capacity of the building aggregate is first addressed through modal and push over analyses. El…
Supporting and constraining factors in the development of university teaching experienced by teachers
2017
Higher education calls for reform, but deeper knowledge about the prerequisites for teaching development and pedagogical change is missing. In this study, 51 university teachers’ experiences of supportive or constraining factors in teaching development were investigated in the context of Finland’s multidisciplinary network. The findings reveal that the supportive factors in teaching development arise from the nature of the development itself, i.e. from the teachers’ opportunities to act as active agents in an authentic development process. Furthermore, the circumstances of the development also play essential roles (both constraining and supportive) in teaching development. Such support, at …
Hsp60 and human aging: Les liaisons dangereuses
2013
Stressors can cause abnormal intracellular accumulation of Hsp60 and its localization in extramitochondrial sites, secretion, and circulation, with immune system activation. Dysfunction of chaperones associated with their quantitative and qualitative decline with aging (chaperonopathies of aging) characterizes senescence and is a potential causal factor in the physiological deterioration that occurs with it. The role of Hsp60 in aging is not easy to elucidate, because aging is accompanied by pathologies (e.g., cardiovascular and neurodegenerative disorders, osteoporosis, diabetes, cancer, etc.) in which Hsp60 has been implicated but, although those disorders are more frequent in the elderly…
Npl3 stabilizes R-loops at telomeres to prevent accelerated replicative senescence.
2019
Abstract Telomere shortening rates must be regulated to prevent premature replicative senescence. TERRA R‐loops become stabilized at critically short telomeres to promote their elongation through homology‐directed repair (HDR), thereby counteracting senescence onset. Using a non‐bias proteomic approach to detect telomere binding factors, we identified Npl3, an RNA‐binding protein previously implicated in multiple RNA biogenesis processes. Using chromatin immunoprecipitation and RNA immunoprecipitation, we demonstrate that Npl3 interacts with TERRA and telomeres. Furthermore, we show that Npl3 associates with telomeres in an R‐loop‐dependent manner, as changes in R‐loop levels, for example, …
Dietary prevention of visual function and cognitive decline by omega-3 polyunsaturated fatty acids in Senescence Accelerated Mouse P8 (SAM P8)
2008
International audience; Purpose: : Neuronal tissues such as the brain and the retina contain elevated amounts of long-chain omega-3 polyunsaturated fatty acids (PUFAs) and particularly docosahexaenoic acid (DHA). DHA concentrations are known to decrease in the aging brain and are associated with cognitive decline. The senescence-accelerated mouse prone 8 (SAM P8) is a mouse model for aging that exhibits deficits in cognitive performances as well as alterations of retinal functionality (ARVO 2004 E-abstract 797). The aim of this study was to evaluate the effects of a dietary supplementation with DHA on mood, cognition and visual functionality of SAM P8 during aging. Methods: : SAM P8 mice we…
Nxnl2 splicing results in dual functions in neuronal cell survival and maintenance of cell integrity
2012
International audience; The rod-derived cone viability factors, RdCVF and RdCVF2, have potential therapeutical interests for the treatment of inherited photoreceptor degenerations. In the mouse lacking Nxnl2, the gene encoding RdCVF2, the progressive decline of the visual performance of the cones in parallel with their degeneration, arises due to the loss of trophic support from RdCVF2. In contrary, the progressive loss of rod visual function of the Nxnl2-/- mouse results from a decrease in outer segment length, mediated by a cell autonomous mechanism involving the putative thioredoxin protein RdCVF2L, the second spliced product of the Nxnl2 gene. This novel signaling mechanism extends to o…
The expansion $\star$ mod $\bar{o}(\hbar^4)$ and computer-assisted proof schemes in the Kontsevich deformation quantization
2019
The Kontsevich deformation quantization combines Poisson dynamics, noncommutative geometry, number theory, and calculus of oriented graphs. To manage the algebra and differential calculus of series of weighted graphs, we present software modules: these allow generating the Kontsevich graphs, expanding the noncommutative & x22c6;-product by using a priori undetermined coefficients, and deriving linear relations between the weights of graphs. Throughout this text we illustrate the assembly of the Kontsevich & x22c6;-product up to order 4 in the deformation parameter Already at this stage, the & x22c6;-product involves hundreds of graphs; expressing all their coefficients via 149 w…