Search results for "structures"
showing 10 items of 4815 documents
Characterization of poultry egg-white avidins and their potential as a tool in pretargeting cancer treatment.
2003
Chicken avidin and bacterial streptavidin are proteins used in a wide variety of applications in the life sciences due to their strong affinity for biotin. A new and promising use for them is in medical pretargeting cancer treatments. However, their pharmacokinetics and immunological properties are not always optimal, thereby limiting their use in these applications. To search for potentially beneficial new candidates, we screened egg white from four different poultry species for avidin. Avidin proteins, isolated from the duck, goose, ostrich and turkey, showed a similar tetrameric structure, similar glycosylation and stability against both temperature and proteolytic activity of proteinase…
Functionalized lipid tubules as tools for helical crystallization of proteins
1997
The development of functional supramolecular devices built by self-assembly of elementary molecules and with bioactive properties arouses considerable interest in the field of nanotechnology and new materials. We report here the formation of a new class of lipid tubules exhibiting both properties of molecular recognition and crystal formation for the protein streptavidin. These lipid tubules, made of biotin-containing dioctadecylamine molecules, are straight hollow cylinders with a constant diameter of 27 nm and variable length up to several micrometers. They are unilamellar with an inner diameter of about 16 nm, as shown by cryoelectron microscopy. Streptavidin binds to the biotinylated tu…
Repetitiveness Measures based on String Attractors and Burrows-Wheeler Transform: Properties and Applications
2023
Long Non Coding RNA H19: A New Player in Hypoxia-Induced Multiple Myeloma Cell Dissemination
2019
The long non-coding RNA H19 (lncH19) is broadly transcribed in the first stage of development and silenced in most cells of an adult organism
Efficient differentiation of embryonic stem cells into mesodermal precursors by BMP, retinoic acid and Notch signalling
2012
The ability to direct differentiation of mouse embryonic stem (ES) cells into specific lineages not only provides new insights into the pathways that regulate lineage selection but also has translational applications, for example in drug discovery. We set out to develop a method of differentiating ES cells into mesodermal cells at high efficiency without first having to induce embryoid body formation. ES cells were plated on a feeder layer of PA6 cells, which have membrane-associated stromal-derived inducing activity (SDIA), the molecular basis of which is currently unknown. Stimulation of ES/PA6 co-cultures with Bone Morphogenetic Protein 4 (BMP4) both favoured self-renewal of ES cells and…
Limited Resistance Rigid Perfectly Plastic Hinges for Steel Frames
2017
The paper concerns the proposal of a new special device for steel frames that can be utilized as external constraint as well as internal one connecting the structure beam elements. The device is designed as a rigid perfectly plastic hinge characterized by suitably chosen stiffness and resistance. Its constituting material is steel. The elastic stiffness and the limit resistance, treated as independent of each other, are fixed with the aim of satisfying special features required to the structure. The proposed device is thought as a sandwich section with wing thickness appropriately variable. Its dimensions are designed so that it can exhibit the fixed independent stiffness and limit resistan…
Influence of composition(CO2 and Sugar) on aroma release and perception of mint-flavored carbonated beverages
2009
The aim of the present work was to identify and quantify physical mechanisms responsible for in-nose aroma release during the consumption of mint-flavored carbonated beverages in order to better understand how they are perceived. The effect of two composition factors (sugar and CO(2)) was investigated on both the sensory and physicochemical properties of drinks by studying in vitro and in vivo aroma release. Sensory results revealed that the presence of CO(2) increased aroma perception regardless of the sugar content. In agreement with volatility parameters, in vivo measurements showed that carbonated drinks released a greater quantity of aroma compounds in the nose space than non-carbonate…
PVA Hydrogel Electrolyte and Porous Polyisoprene Carbon Nanostructure Composite Based Pressure Sensitive Supercapacitor
2019
Special gratitude is in order to Raimonds Orlovs for temperature dependent resistance measurements. Financial support of project 1.1.1.1/16/A/013, “Hybrid energy harvesting systems” is greatly appreciated.
Coexistence of superconductivity and magnetism by chemical design.
2010
Although the coexistence of superconductivity and ferromagnetism in one compound is rare, some examples of such materials are known to exist. Methods to physically prepare hybrid structures with both competing phases are also known, which rely on the nanofabrication of alternating conducting layers. Chemical methods of building up hybrid materials with organic molecules (superconducting layers) and metal complexes (magnetic layers) have provided examples of superconductivity with some magnetic properties, but not fully ordered. Now, we report a chemical design strategy that uses the self assembly in solution of macromolecular nanosheet building blocks to engineer the coexistence of supercon…
Fabrication of Quasi-One-Dimensional Superconducting Micro- and Nanostructures
2007
Wires capable of conducting electric current are basic blocks of all electronic applications. Of particular interest for nanoelectronics are superconducting elements taking advantage of the superconductor's macroscopic quantum coherence and zero resistance. Recently there appeared indications that due to quantum fluctuations the dissipationless electric current (supercurrent) can be suppressed in ultra-narrow superconducting channels with the effective diameter below approximately 10 nm. In this Review we will describe methods of fabrication of quasi-one-dimensional superconducting micro- and nanowires suitable for electric transport measurements at cryogenic temperatures. In the first sect…