Search results for "structures"
showing 10 items of 4815 documents
Prevalence and Time Trends in Myopia Among Children and Adolescents.
2020
Background Myopia (near-sightedness) is increasing worldwide, especially in Asia. The aim of this study was to describe trends in the prevalence of myopia in Germany. Methods We analyzed data from the German Health Interview and Examination Survey for Children and Adolescents (KiGGS; baseline survey 2003-2006, N = 17 640; wave 2, 2014-2017, N = 15 023). The presence of myopia was determined from a parent questionnaire and validated by the use of a visual aid. The population prevalence of myopia was calculated. Based on the KiGGS wave 2 data, potential risk factors for myopia were identified by means of logistic regression. Results The prevalence of myopia at the age of 0-17 years in Germany…
Filter approach to the stochastic analysis of MDOF wind-excited structures
1999
Abstract In this paper, an approach useful for stochastic analysis of the Gaussian and non-Gaussian behavior of the response of multi-degree-of-freedom (MDOF) wind-excited structures is presented. This approach is based on a particular model of the multivariate stochastic wind field based upon a particular diagonalization of the power spectral density (PSD) matrix of the fluctuating part of wind velocity. This diagonalization is performed in the space of eigenvectors and eigenvalues that are called here wind-eigenvalues and wind-eigenvectors, respectively. From the examination of these quantities it can be recognized that the wind-eigenvectors change slowly with frequency while the first wi…
Senataxin defective in ataxia oculomotor apraxia type 2 is involved in the defence against oxidative DNA damage
2007
Adefective response to DNA damage is observed in several human autosomal recessive ataxias with oculomotor apraxia, including ataxia-telangiectasia. We report that senataxin, defective in ataxia oculomotor apraxia (AOA) type 2, is a nuclear protein involved in the DNA damage response. AOA2 cells are sensitive to H2O2, camptothecin, and mitomycin C, but not to ionizing radiation, and sensitivity was rescued with full-length SETX cDNA. AOA2 cells exhibited constitutive oxidative DNA damage and enhanced chromosomal instability in response to H2O2. Rejoining of H2O2-induced DNA double-strand breaks (DSBs) was significantly reduced in AOA2 cells compared to controls, and there was no evidence fo…
Influence of proprioceptive information on space orientation on the ground and in orbital weightlessness
1989
Conscious space orientation depends on afferent information from different sense organs including the labyrinth, the eyes, tactile cues from the skin, joint receptors, muscle spindles, tendon organs and possibly viscera. An important role is played by impulses from the cervical position receptors in interaction with concomitant information from the otolith system. In order to isolate the effect of cervical position receptors from that of the otolith system, space experiments in orbital weightlessness and in parabolic aircraft flight were performed. It was found that stimulation of the neck receptors in weightlessness markedly influences the perception of the subjective vertical and horizont…
Evidence of positive tectonic inversion in the north-central sector of the Sicily Channel (Central Mediterranean)
2016
In order to unravel the tectonic evolution of the north-central sector of the Sicily Channel (Central Mediterranean), a seismo-stratigraphic analysis of single- and multi-channel seismic reflection profiles has been carried out. This allowed to identify, between 20 and 50 km offshore the central-southern coast of Sicily, a ~80-km-long deformation belt, characterized by a set of WNW–ESE to NW–SE fault segments showing a poly-phasic activity. Within this belt, we observed: i) Miocene normal faults reactivated during Zanclean–Piacenzian time by dextral strike-slip motion, as a consequence of the Africa–Europe convergence; ii) releasing and restraining bend geometries forming well-developed pul…
Auditory cortical event-related potentials to pitch deviances in rats
1998
Abstract We recorded epidural event-related potentials (ERPs) from the auditory cortex in anesthetized rats when pitch-deviant tones were presented in a homogenous series of standard tones (oddball condition). Additionally, deviant tones were presented without standard tones (deviant-alone condition). ERPs to deviant tones in the oddball condition differed significantly from ERPs to standard tones at the latency range of 63–243 ms. On the other hand, ERPs to deviant tones in the deviant-alone condition did not differ from ERPs to standard tones until 196 ms from stimulus onset. The results suggest that oddball stimuli can be neurophysiologically discriminated in anesthetized rats. Furthermo…
The impact of a concurrent motor task on auditory and visual temporal discrimination tasks
2016
Previous studies have shown the presence of an interference effect on temporal perception when participants are required to simultaneously execute a nontemporal task. Such interference likely has an attentional source. In the present work, a temporal discrimination task was performed alone or together with a self-paced finger-tapping task used as concurrent, nontemporal task. Temporal durations were presented in either the visual or the auditory modality, and two standard durations (500 and 1, 500 ms) were used. For each experimental condition, the participant’s threshold was estimated and analyzed. The mean Weber fraction was higher in the visual than in the auditory modality, but only for…
Modifying auditory perception with prisms? Aftereffects of prism adaptation on a wide auditory spectrum in musicians and nonmusicians
2021
Prism adaptation consists of pointing to visual targets while wearing prisms that shift the visual field laterally. The aftereffects are not restricted to sensorimotor level but extend to spatial cognition. There is a link between spatial representation and auditory frequency, with an association of low frequencies on the left side and high frequencies on the right side of space. The present study aimed first at evaluating the representation of auditory frequencies on a wide range of frequencies in musicians and nonmusicians. We used the ‘auditory interval bisection judgment’ within three auditory intervals. The results showed a pseudoneglect behavior in pretest in musicians and nonmusician…
Cross-modal aftereffects of visuo-manual prism adaptation: Transfer to auditory divided attention in healthy subjects.
2021
OBJECTIVE Prism adaptation was shown to modify auditory perception. Using a dichotic listening task, which assesses auditory divided attention, benefits of a rightward prism adaptation were demonstrated in neglect patients (i.e., a syndrome following right hemisphere brain damage) by reducing their left auditory extinction. It is currently unknown whether prism adaptation affects auditory divided attention in healthy subjects. In the present study, we investigated the aftereffects of prism adaptation on dichotic listening. METHOD A sample of 47 young adults performed a dichotic listening task, in which pairs of words were presented with two words sounded simultaneously, one in each ear. Thr…
The role of Aurora-A inhibitors in cancer therapy
2007
Recently, new chemotherapy agents which target the non-structural components of mitosis have been developed. An important protein involved in several mitotic phases is the Aurora-A protein. By means of the phosphorylation of different substrates, Aurora-A regulates the correct development of the various phases of mitosis. The kinase activity of this protein makes Aurora-A an excellent candidate as an oncogene. The first data of Aurora-A involvement in cancer regarded the identification of Aurora-A overexpression in primary breast and colon tumour samples. With regard to the predictive role of Aurora-A, it has been shown that its overexpression disrupts the spindle checkpoint activated by pa…