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showing 10 items of 1268 documents
A new exciting hypothesis: direct correlation between periodontitis and clinical evolution of COVID-19 patients.
2020
The aim of the present opinion article is to hypothesize a possible correlation between clinical evolution of COVID-19 and a chronic inflammatory disease such as periodontitis. Reviews have been performed about the correlations between COVID-19 and IL-6, COVID-19 and diabetes, diabetes and periodontitis. Several studies discussed the role played by IL-6 in the pathogenetic mechanisms of COVID-19. A recent study found that COVID-19 adult patients with diabetes, without other comorbidities, were at greater risk of numerous diseases COVID related, such as severe pneumonia and excessive uncontrolled inflammatory responses. Besides, serum levels of inflammation-related biomarkers, such as IL-6, …
In vivo phage display: identification of organ-specific peptides using deep sequencing and differential profiling across tissues.
2021
Abstract In vivo phage display is widely used for identification of organ- or disease-specific homing peptides. However, the current in vivo phage biopanning approaches fail to assess biodistribution of specific peptide phages across tissues during the screen, thus necessitating laborious and time-consuming post-screening validation studies on individual peptide phages. Here, we adopted bioinformatics tools used for RNA sequencing for analysis of high-throughput sequencing (HTS) data to estimate the representation of individual peptides during biopanning in vivo. The data from in vivo phage screen were analyzed using differential binding—relative representation of each peptide in the target…
Hemorheologic profile of hyperlipidemic patients treated with gemfibrozil
1996
Abstract We measured the plasma lipid levels and the macrorheologic (whole-blood, plasma, and serum viscosity levels; fibrinogen; hematocrit; mean erythrocyte aggregation; and whole-blood filterability) and microrheologic (erythrocyte membrane fluidity and red cell membrane protein lateral mobility) determinants in a group of 19 hyperlipidemic patients (Fredrickson's classification phenotype IIa, 12 patients; phenotype IV, 4; phenotype IIb, 3) at baseline and after 45 and 90 days of treatment with gemfibrozil (900 mg orally once a day). At baseline we noted statistically significant increases in plasma viscosity level, fibrinogen, and mean erythrocyte aggregation, as well as a statistically…
Emerging approaches for the treatment of hypertriglyceridemia.
2013
Hypertriglyceridemia is frequent in diabetic and obese subjects, who are at increased risk for cardiovascular diseases (CVD). Increased triglycerides (TG) are a hallmark of atherogenic dyslipidemia, representing a marker of atherogenic small dense low-density lipoproteins (sdlDL). Importantly, non-fasting/postprandial TG measurements tend to be emphasized in clinical practice for the prediction of CVD, and TG-lowering agents (primarily fibrates) have a beneficial effect on atherogenic dyslipidemia, reducing TG-rich particles and ultimately lowering the production of sdlDL. The combination of omega-3 fatty acids and statins is also recommended, and widely used in clinical practice for subjec…
S.5.4 - ENHANCING RECOGNITION MEMORY PERFORMANCE WITH RTMS IN HEALTHY SUBJECTS AND NEUROLOGICAL PATIENTS
2013
Face-to-Face with the Doctor Online: Phenomenological Analysis of Patient Experience of Teleconsultation.
2022
The global crisis of the COVID-19 pandemic has considerably accelerated the adoption of teleconsultation—a form of consultation between patient and health care professional that occurs via videoconferencing platforms. For this reason, it is important to investigate the way in which this form of interaction modifies the nature of the clinical encounter and the extent to which this modification impacts the healing process. For this purpose, I will refer to insights into the clinical encounter as a face-to-face encounter drawn from the phenomenology of medicine (R. Zaner, K. Toombs, E. Pellegrino). I will also take into account a criticism that has been expressed by various contemporary phenom…
INTRODUCTION
2021
Unraveling of an original mechanism of hypometria in human using a new myohaptic device — The Wristalyzer
2009
We report a novel form of hypometria in a patient presenting a spinocerebellar ataxia type 2 (SCA2; 32 repeats; Age: 44). We investigated fast pointing (FP) and fast reversal (FR) single-joint movements performed under artificial damping conditions using our myohaptic device called Wristalyzer, which allows an instantaneous regulation of the mechanical characteristics of a wrist manipulandum. The wristalyzer controller has a range of motion from −1 rad to +1 rad. The inertia of the motor/handgrip is 0.004 kg × m2. Movements were studied in free mode and with damping either at 0.1 Nms/rad or 0.2 Nms/rad. Subjects performed sets of FP movements and FR movements over 3 distances (targets: 0.2,…
Sex differences in estimation of time intervals and in reaction time are removed by moderate but not high doses of caffeine in coffee
2002
Estimation of the passage of time in the seconds-to-minutes range and reaction time are strongly dependent on a hypothetical internal clock. Dopamine is the neurotransmitter most closely related to the rate of this clock. Caffeine, probably the most consumed drug in the world, leads to an augmentation of dopamine neurotransmission. In this study coffee, which reproduces the conditions under which caffeine is normally ingested, containing 3, 75, 150 or 300 mg of caffeine, was given to healthy male and female volunteers. A computerized time estimation and reaction time test was carried out 50 min after ingestion. Sex differences in placebo control subjects (who took decaffeinated coffee with …