Search results for "supervised machine learning"
showing 10 items of 11 documents
Evaluation of tumor immune contexture among intrinsic molecular subtypes helps to predict outcome in early breast cancer
2021
BackgroundThe prognosis of early breast cancer is linked to clinic-pathological stage and the molecular characteristics of intrinsic tumor cells. In some patients, the amount and quality of tumor-infiltrating immune cells appear to affect long term outcome. We aimed to propose a new tool to estimate immune infiltrate, and link these factors to patient prognosis according to breast cancer molecular subtypes.MethodsWe performed in silico analyses in more than 2800 early breast cancer transcriptomes with corresponding clinical annotations. We first developed a new gene expression deconvolution algorithm that accurately estimates the quantity of immune cell populations (tumor immune contexture,…
Identification of novel compounds against three targets of SARS CoV-2 coronavirus by combined virtual screening and supervised machine learning.
2021
Coronavirus disease 2019 (COVID-19) is a major threat worldwide due to its fast spreading. As yet, there are no established drugs available. Speeding up drug discovery is urgently required. We applied a workflow of combined in silico methods (virtual drug screening, molecular docking and supervised machine learning algorithms) to identify novel drug candidates against COVID-19. We constructed chemical libraries consisting of FDA-approved drugs for drug repositioning and of natural compound datasets from literature mining and the ZINC database to select compounds interacting with SARS-CoV-2 target proteins (spike protein, nucleocapsid protein, and 2′-o-ribose methyltransferase). Supported by…
Predicting hospital associated disability from imbalanced data using supervised learning.
2019
Hospitalization of elderly patients can lead to serious adverse effects on their functional capability. Identifying the underlying factors leading to such adverse effects is an active area of medical research. The purpose of the current paper is to show the potential of artificial intelligence in the form of machine learning to complement the existing medical research. This is accomplished by studying the outcome of hospitalization of elderly patients as a supervised learning task. A rich set of features characterizing the medical and social situation of elderly patients is leveraged and using confusion matrices, association rule mining, and two different classes of supervised learning algo…
Automated prostate gland segmentation based on an unsupervised fuzzy C-means clustering technique using multispectral T1w and T2w MR imaging
2017
Prostate imaging analysis is difficult in diagnosis, therapy, and staging of prostate cancer. In clinical practice, Magnetic Resonance Imaging (MRI) is increasingly used thanks to its morphologic and functional capabilities. However, manual detection and delineation of prostate gland on multispectral MRI data is currently a time-expensive and operator-dependent procedure. Efficient computer-assisted segmentation approaches are not yet able to address these issues, but rather have the potential to do so. In this paper, a novel automatic prostate MR image segmentation method based on the Fuzzy C-Means (FCM) clustering algorithm, which enables multispectral T1-weighted (T1w) and T2-weighted (T…
Evaluation of Ensemble Machine Learning Methods in Mobile Threat Detection
2017
The rapid growing trend of mobile devices continues to soar causing massive increase in cyber security threats. Most pervasive threats include ransom-ware, banking malware, premium SMS fraud. The solitary hackers use tailored techniques to avoid detection by the traditional antivirus. The emerging need is to detect these threats by any flow-based network solution. Therefore, we propose and evaluate a network based model which uses ensemble Machine Learning (ML) methods in order to identify the mobile threats, by analyzing the network flows of the malware communication. The ensemble ML methods not only protect over-fitting of the model but also cope with the issues related to the changing be…
Machine Learning: An Overview and Applications in Pharmacogenetics.
2021
This narrative review aims to provide an overview of the main Machine Learning (ML) techniques and their applications in pharmacogenetics (such as antidepressant, anti-cancer and warfarin drugs) over the past 10 years. ML deals with the study, the design and the development of algorithms that give computers capability to learn without being explicitly programmed. ML is a sub-field of artificial intelligence, and to date, it has demonstrated satisfactory performance on a wide range of tasks in biomedicine. According to the final goal, ML can be defined as Supervised (SML) or as Unsupervised (UML). SML techniques are applied when prediction is the focus of the research. On the other hand, UML…
Mixed Fault Classification of Sensorless PMSM Drive in Dynamic Operations Based on External Stray Flux Sensors
2022
This paper aims to classify local demagnetisation and inter-turn short-circuit (ITSC) on position sensorless permanent magnet synchronous motors (PMSM) in transient states based on external stray flux and learning classifier. Within the framework, four supervised machine learning tools were tested: ensemble decision tree (EDT), k-nearest neighbours (KNN), support vector machine (SVM), and feedforward neural network (FNN). All algorithms are trained on datasets from one operational profile but tested on other different operation profiles. Their input features or spectrograms are computed from resampled time-series data based on the estimated position of the rotor from one stray flux sensor t…
Artificial intelligence in the cyber security environment
2019
Artificial Intelligence (AI) is intelligence exhibited by machines. Any system that perceives its environment and takes actions that maximize its chance of success at some goal may be defined as AI. The family of AI research is rich and varied. For example, cognitive computing is a comprehensive set of capabilities based on technologies such as deep learning, machine learning, natural language processing, reasoning and decision technologies, speech and vision technologies, human interface technologies, semantic technology, dialog and narrative generation, among other technologies. Artificial intelligence and robotics have steadily growing roles in our lives and have the potential to transfo…
Anomaly detection in wireless sensor networks
2016
Wireless Sensor Network can be defined as a network of integrated sensors responsible for environmental sensing, data processing and communication with other sensors and the base station while consuming low power. Today, WSNs are being used in almost every part of life. The cost effective nature of WSNs is beneficial for environmental monitoring, production facilities and security monitoring. At the same time WSNs are vulnerable to security breaches, attacks and information leakage. Anomaly detection techniques are used to detect such activities over the network that do not conform to the normal behavior of the network communication. Supervised Machine learning approach is one way to detect…
Course Satisfaction in Engineering Education Through the Lens of Student Agency Analytics
2020
This Research Full Paper presents an examination of the relationships between course satisfaction and student agency resources in engineering education. Satisfaction experienced in learning is known to benefit the students in many ways. However, the varying significance of the different factors of course satisfaction is not entirely clear. We used a validated questionnaire instrument, exploratory statistics, and supervised machine learning to examine how the different factors of student agency affect course satisfaction among engineering students (N = 293). Teacher’s support and trust for the teacher were identified as both important and critical factors concerning experienced course satisf…