Search results for "support"
showing 10 items of 2310 documents
RIP-Chip analysis supports different roles for AGO2 and GW182 proteins in recruiting and processing microRNA targets.
2019
Background MicroRNAs (miRNAs) are small non-coding RNA molecules mediating the translational repression and degradation of target mRNAs in the cell. Mature miRNAs are used as a template by the RNA-induced silencing complex (RISC) to recognize the complementary mRNAs to be regulated. To discern further RISC functions, we analyzed the activities of two RISC proteins, AGO2 and GW182, in the MCF-7 human breast cancer cell line. Methods We performed three RIP-Chip experiments using either anti-AGO2 or anti-GW182 antibodies and compiled a data set made up of the miRNA and mRNA expression profiles of three samples for each experiment. Specifically, we analyzed the input sample, the immunoprecipita…
Abatement of Acid Orange 7 in macro and micro reactors. Effect of the electrocatalytic route
2014
Abstract The electrochemical treatment of aqueous solutions contaminated by Acid Orange 7 (AO7) was widely studied with the main objective to evaluate as the electrocatalytic route affects the performances of the degradation process in macro and microfluidic cells. Direct anodic oxidation (EO), electro-Fenton (EF), electro-generation of active chlorine (IOAC) and coupled processes were investigated in macro and microfluidic reactors in order to select more effective conditions for the treatment of such compound. The effect of numerous operative parameters (such as nature of the electrode materials, coupling of processes, flow rate, current density and inter-electrode distance) on the perfor…
Determination of rate constants of ion transfer kinetics across immiscible electrolyte solutions
1998
Abstract The rotating diffusion cell was used to study ion transfer across the interface between two immiscible electrolyte solutions. Tetrabutylammonium was chosen as the transferring cation and lithium chloride as the supporting electrolyte in aqueous phase. Tetrabutylammonium tetrakis-(4-fluorophenyl)-borate in 2-nitrophenyl-octylether was used as the organic electrolyte solution supported in the porous membrane. The quasi-steady state current–voltage curves were measured both by applying potential steps and by imposing a slow potential sweep. The analysis of experimental results was based on the comparison with the theoretical current–voltage curves and on the Koutecky–Levich plots. The…
Peptides analysis in blood plasma using on-line system of supported liquid membrane and high-performance liquid chromatography
2005
The potential of using supported liquid membrane (SLM) technique, combined with reversed-phase high-performance liquid chromatography (RP-HPLC) has been investigated for the determination of peptides in human blood plasma. The peptides studied were (DL)Leu(DL)Phe, MetLeuPhe, GlyLeuTyr and ValGluProlleProTyr. The carrier (Aliquat 336) was incorporated in membrane phase in order to facilitate the transport of investigated peptides. After extraction, the analyte-enriched acceptor phase was directly injected into an HPLC system for analysis. With SLM, high selectivity and efficiency were achieved for extraction of peptides in aqueous solutions. Lower extraction efficiency was obtained in plasma…
Supported liquid membrane extraction of aromatic aminophosphonates
2001
Abstract A fast and efficient supported liquid membrane (SLM) extraction system for the series of substituted aromatic aminophosphonates was elaborated. The mass transfer of solute was examined in terms of operator (pH and ionic strength of water phase, composition of membrane phase and the concentration of analyte) dependent parameters. Additionally, the influence of the aminophosphonates structure on the extraction efficiency was examined. From the results it can be concluded that the most effective conditions of membrane process are 10% (w/w) carrier concentration (Aliquat 336) in the liquid membrane, high pH of donor phase (pH=11) and moderate salt concentration (0.4 M NaCl) in the acce…
Diagnostic algorithm for familial chylomicronemia syndrome
2016
International audience; Background: Familial chylomicronemia syndrome (FCS) is a rare genetic disease that leads to severe hypertriglyceridemia often associated with recurrent episodes of pancreatitis. The recognition and correct diagnosis of the disease is challenging due to its rarity, and to the lack of specificity of signs and symptoms. Lipid experts, endocrinologists, gastroenterologists, pancreatologists, and general practitioners may encounter patients who potentially have FCS. Therefore, cooperation between experts and improved knowledge of FCS is essential in improving the diagnosis. Currently, a consensus on best practice for the diagnosis of FCS is lacking. Methods: Aiming to def…
A new paradigm for pattern classification: Nearest Border Techniques
2013
Published version of a chapter in the book: AI 2013: Advances in Artificial Intelligence. Also available from the publisher at: http://dx.doi.org/10.1007/978-3-319-03680-9_44 There are many paradigms for pattern classification. As opposed to these, this paper introduces a paradigm that has not been reported in the literature earlier, which we shall refer to as the Nearest Border (NB) paradigm. The philosophy for developing such a NB strategy is as follows: Given the training data set for each class, we shall first attempt to create borders for each individual class. After that, we advocate that testing is accomplished by assigning the test sample to the class whose border it lies closest to…
Application of an intelligent study and research support system for clinical anatomy in a cooperation scenario
2008
Scientific research and teaching are strongly interrelated. A student should be educated both to the fundamentals of a discipline and to the research tasks as the future development of a discipline is entrusted to the students of today. Computer based tutoring systems already showed useful in pursuing the former target while the Intelligent Study and Research Support System developed at DINFO may be used to fulfill both in an integrated manner. This paper introduces the possible application of the ISRSS to training of Clinical Anatomy in a scenario of international cooperation among academic institutions.
The Differential Relations between Perceived Social Support and Rumination-Associated Goals
2013
In this study with N = 93 student participants, we employed a daily process approach to investigate sadness-associated rumination in daily life. Specifically, we examined whether the attainment of coping-related goals that people intend to achieve with their sadness-associated rumination were associated with changes in perceived social support. Moreover, we investigated the relations between sadness-related cognitive appraisals, goal pursuit and attainment, and ruminative process variables. Perceived social support was positively related to the attainment of resolution-focused goals, but not to understanding-focused goals, suggesting that social support is particularly associated with a fun…
Supporting bereaved people: a qualitative study on the experience of informal support providers, before and during the pandemic scenario
2023
The COVID-19 outbreak has further highlighted the need to strengthen support networks tosustain grieving people. However, we know very little about the experience of those who,because of their emotional connection with the bereaved person or of their social function,find themselves supporting people in grief. The current study aimed to analyze the experi-ence of grievers’informal support providers (relatives and friends, teachers, religious leaders,funeral providers, pharmacists, volunteers, and social service workers). 162 in-depth inter-views were collected (meanage¼42.3,SD¼14.9; women¼63.6%). Findings highlight twodifferent ways of talking about one’s experience and two different ways of…