Search results for "suppression"
showing 10 items of 404 documents
Functionnal aspects of biodiversity in relation to plant health
2009
Texte intégral; The most visible impact of human activities on biodiversity concerns species which are part of our cultural heritage but a huge part of the diversity is still hidden, mainly in the ocean, in extreme environments and of course in the soil. Although some estimations can be proposed, they are all considered as under-evaluations of the putative number of taxa that could be present on (in?) the planet Earth. Despite it is not yet known, this biodiversity contributes to different services through the functioning of ecosystems, and thus influences the sustainability of these ecosystems. This was the case for instance when the unsuspected major roles of the archeabacteria in the bi…
Circulating Histones and Nucleosomes as Biomarkers in Sepsis and Septic Shock
2016
Sepsis, severe sepsis, and septic shock are among the leading causes of death worldwide and their incidence is constantly increasing. Despite early intervention in intensive care units (ICUs) mortality remains high. There is great interest in understanding the genetics and epigenetics of the host in response to infection because of two reasons: the peculiarities of each patient, and the unclear associations identified between genetic polymorphisms and susceptibility to sepsis. In addition, chromatin remodeling and epigenetic changes occur in crucial genes involved in the inflammatory response and also in the immunosuppression found in sepsis. The early and accurate diagnosis of sepsis is a …
Graft-Versus-Host Disease or Infection: Rapid Detection of HLA Mismatch-Reactive T Cells Ex Vivo Can Facilitate Diagnosis and Guide Therapy after All…
2007
Abstract Diagnosis of graft-versus-host disease (GVHD) is mainly based on clinical features and on tissue biopsies. However, clinicians and pathologists are well aware of cases, in which GVHD cannot be distinguished from infections arising from severe immunodeficiency after allogeneic stem-cell transplantation (SCT). This may pose a deep therapeutic dilemma of whether to modify immunosuppressive treatment or to use donor lymphocyte infusion (DLI) for promoting anti-microbial immunity. We observed a 68-year-old patient with myelodysplastic syndrome who developed acute GVHD grade II of skin and gut at d+16 after T-cell depleted reduced-intensity SCT (Fig. 1). GVHD was confirmed by histology a…
Regeneration After CNS Lesion: Help from the Immune System?
2010
Traumatic injury to the central nervous system (CNS) is followed by an inflammatory response, which is characterized by at least two very distinct phases: First, a short highly controlled burst of acute inflammatory defense and second, a long-term remodeling phase. Similarly, at least one or two phases of T-cell infiltration have been described in CNS trauma models suggesting differential functions of T cells in the acute and remodeling phase. Thus, the role of T cells in CNS trauma is still controversial. Interestingly, vaccine strategies and injections of autoimmune T cells led to both exacerbation of CNS damage after trauma in some models and improvement in others. Here, we suggest that …
Hepatitic C virus infection and autoimmunity : clinical features, diagnostic tools and therapeutical aspects
1995
Summary Since the genom of the hepatitis C virus (HCV) was detected the pathogenesis of a distinct group of chronic liver disease and some non-hepatic disorders of sofar unknown origin could be newly established. A wide variety of clinical features including vasculitis, glomerulonephritis, porphyria and rheumatoid-like symptoms may become apparant separately or in combination. HCV can be precipitated in cryoglobulins and tissue-related HCV was found in liver and kidney specimen, for instance. HCV-related cryoglobulinemia or circulating immune complexes often occur with vasculitis. Hematological changes may be present such as thrombocytopenia. A considerable amount of patients show circulati…
Effects of daylight and artificial light on melatonin suppression in educational environment.
2012
An analysis of the characteristics of daylight in a scholastic environment was carried out by comparing SPDs and CCTs of the natural source (sky) during typical winter days with contemporaneous measurements of spectral irradiances and CCTs detected at the eyes level. Data obtained from these measurements together with those detected with artificial light, were used to evaluate the effects on melatonin suppression during the day according to the procedure proposed by Rea et al [2]. Despite illuminances on desks under natural and artificial light corresponded to the EN 12464-1 Standard requirements, the irradiances detected at eye's level, which are essential for melatonin suppression, do not…
A phenomenological investigation of the emotional experiences of elite Brazilian coaches
2014
Coaches of elite athletes often need to work under stressful conditions and therefore may experience moments where emotional intensity is running very high. As a result, their physical and mental well-being may be affected. Nevertheless, little attention has been given to the emotional side of the coaches in current scientific literature (Potrac, Jones, Purdy, Nelson, & Marshall, 2013). With this in mind, the purpose of this study was to explore coaches’ stressors and other pleasant and unpleasant emotional experiences related to their coaching performance. Specifically, coaches’ awareness of their emotions and situational triggers were examined. Six highly experienced Brazilian coaches wer…
Perceived motivational climate influences athletes’ emotion regulation strategies, emotions, and psychobiosocial experiences
2022
The purpose of the study was to investigate whether athletes’ perceptions about the motivational climate created by their coach influence emotion regulation strategies (i.e., cognitive reappraisal and expressive suppression), emotions, and psychobiosocial experiences of athletes. A sample of 459 competitive athletes (201 women, 258 men), aged 16–35 years, drawn from individual and team sports, completed self-assessment measures of perceived motivational climate, emotion regulation, sport emotions, and psychobiosocial experiences. Main results from structural equation modeling showed that perceived mastery climate was positively related to cognitive reappraisal, pleasant emotions, and psycho…
Measurements of inclusive jet spectra in pp and central Pb-Pb collisions at √sNN = 5.02 TeV
2020
This article reports measurements of the pT-differential inclusive jet cross section in pp collisions at √s = 5.02 TeV and the pT-differential inclusive jet yield in Pb-Pb 0-10% central collisions at √sNN = 5.02 TeV. Jets were reconstructed at midrapidity with the ALICE tracking detectors and electromagnetic calorimeter using the anti-kT algorithm. For pp collisions, we report jet cross sections for jet resolution parameters R=0.1-0.6 over the range 20<pT,jet<140 GeV/c, as well as the jet cross-section ratios of different R and comparisons to two next-to-leading-order (NLO)-based theoretical predictions. For Pb-Pb collisions, we report the R=0.2 and R=0.4 jet spectra for 40<pT,jet<140 GeV/c…
Measurement of θ13 in Double Chooz using neutron captures on hydrogen with novel background rejection techniques
2016
The Double Chooz collaboration presents a measurement of the neutrino mixing angle θ[subscript 13] using reactor [bar over ν[subscript e]] observed via the inverse beta decay reaction in which the neutron is captured on hydrogen. This measurement is based on 462.72 live days data, approximately twice as much data as in the previous such analysis, collected with a detector positioned at an average distance of 1050 m from two reactor cores. Several novel techniques have been developed to achieve significant reductions of the backgrounds and systematic uncertainties. Accidental coincidences, the dominant background in this analysis, are suppressed by more than an order of magnitude with respec…