Search results for "survival analysi"

Flexible Bayesian survival models with application in biometric studies

2018

El análisis de supervivencia es una metodología estadística diseñada para analizar datos procedentes de estudios científicos relativos a tiempos de ocurrencia de uno o varios eventos de interés. La duración de estos tiempos suele conocerse como tiempos de supervivencia debido a los particulares orígenes de esta metodología en contextos exclusivamente médicos y demográficos. Durante las últimas décadas, la literatura científica en este campo ha sido muy prolífica y su aplicación se ha extendido a múltiples áreas de conocimiento. Los procedimientos estadísticos propios de esta metodología empezaron a abordarse desde el marco inferencial frecuentista. Sin embargo, en los últimos años la utiliz…

Common genetic variation of the cholesteryl ester transfer protein gene strongly predicts future cardiovascular death in patients with coronary arter…

2003

OBJECTIVES We sought to evaluate the association between cholesteryl ester transfer protein (CETP) genotypes and the risk of future cardiovascular mortality in patients with coronary artery disease (CAD). BACKGROUND Polymorphisms of the CETP gene influence CETP activity and high-density lipoprotein (HDL) cholesterol concentration and might affect the long-term prognosis and response to statin therapy in patients with CAD. METHODS We used serum samples and deoxyribonucleic acid collected at baseline from a prospective cohort of 1,211 patients with CAD prospectively followed up (median follow-up of 4.1 years), 82 of whom experienced a fatal cardiovascular event. The CETP/C-629A and I405V poly…

Immunostimulants in prevention of columnaris disease of rainbow trout, Oncorhynchus mykiss (Walbaum).

2009

Effect of somatic cell count level on functional longevity in Valle del Belice dairy sheep assessed using survival analysis.

2009

The objectives of this study were to evaluate the effect of somatic cell count (SCC) on functional longevity and to estimate the heritability of functional longevity using survival analysis in Valle del Belice dairy sheep. A total of 4,880 lactations of 2,190 ewes from 11 flocks were used. In this study, SCC was considered as an indication of subclinical mastitis. In case of clinical cases, identified by the technicians at milking time, test-day weights and milk samples of those ewes were not considered. Somatic cells were analyzed as counts, without any transformation, and were grouped in 3 classes based on the observed SCC maximum (mxSCC). The mxSCC classes, expressed as 103 cells/mL, wer…

Time-to-event analysis of mastitis at first-lactation in Valle del Belice ewes

2007

A time-to-event study for mastitis at first-lactation in Valle del Belice ewes was conducted, using survival analysis with an animal model. The goals were to evaluate the effect of lambing season and level of milk production on the time from lambing to the day when a ewe experienced a test-day with a recorded SCC greater than or equal to 750,000 cells/ml, and to estimate, for this trait, its heritability and the percentage of variation explained by the flock-year of lambing effect. A dataset with 2468 first-lactation records, collected from 1998 to 2003 in Valle del Belice ewes allocated in 17 flocks, was used. The Cox model used included lambing season and total milk yield adjusted for lac…

Polymorphisms in DNA repair genes modulate survival in cisplatin/gemcitabine-treated non-small-cell lung cancer patients.

2006

Abstract Background: Impaired DNA repair capacity may favorably affect survival in cisplatin/gemcitabine-treated non-small-cell lung cancer (NSCLC) patients. We investigated the association of survival with genetic polymorphisms in X-ray repair cross-complementing group 1 and group 3 (XRCC3), xeroderma pigmentosum group D (XPD), excision repair cross-complementing group 1, ligase IV, ribonucleotide reductase, TP53, cyclooxygenase-2, interleukin-6, peroxisome proliferator-activated receptor γ, epidermal growth factor, methylene-tetra-hydrofolate reductase and methionine synthase. Patients and methods: One hundred and thirty-five stage IV or IIIB (with malignant pleural effusion) NSCLC patien…

Immunomodulatory effects of dietary β-1,3-glucan from Euglena gracilis in rainbow trout (Oncorhynchus mykiss) immersion vaccinated against Yersinia r…

2012

Abstract Potential immunostimulatory effects of orally administered β-glucan were investigated in combination with immersion vaccination against enteric redmouth disease caused by Yersinia ruckeri in rainbow trout (Oncorhynchus mykiss). A linear, unbranched and pure (purity ≥98%) β-1,3-glucan (syn. paramylon) from the alga Euglena gracilis was applied at an inclusion level of 1% β-glucan in feed administered at a rate of 1% biomass day−1 for 84 consecutive days. Fish were vaccinated after two weeks of experimental feeding and bath challenged with live Y. ruckeri six weeks post-vaccination. Blood and head kidney were sampled at day 0, 13 (1 day pre-vaccination), 15, 55, 59 (day 3 post-challe…

A partial review of cure models with an application to French cancer registries data to improve patients' access to insurance and credit

2016

International audience; BackgroundSurvival cure models are widely used in public health researches to analyze time-to-event data in which some subjects would never experience the event of interest; these subjects are said to be statistically cured. There are two types of cure models, the mixture cure modeland the non-mixture cure model which were first formulated respectively by Boag(1949)[1] and Yakovlev et al. (1993) [2]. These models have been intensively developed [3,4 among others] and have also been extended to the net survival framework [5-7 for instance].In cancersurvival analysis,net survival is a measure of survival in the hypothetical world wherecancer would bethe only possible c…

Factors related to the relative survival of patients with diffuse large B-cell lymphoma in a population-based study in France: does socio-economic st…

2017

IF 7.702; International audience; The survival of patients with diffuse large B-cell lymphoma has increased during the last decade as a result of addition of anti-CD20 to anthracycline-based chemotherapy. Although the trend is encouraging, there are persistent differences in survival within and between the USA and European countries suggesting that non-biological factors play a role. Our aim was to investigate the influence of such factors on relative survival of patients with diffuse large B-cell lymphoma. We conducted a retrospective, multicenter, registry-based study in France on 1165 incident cases of diffuse large B-cell lymphoma between 2002 and 2008. Relative survival analyses were p…

Modelling codling moth damage as a function of adult monitoring and crop protection: A survival generalized linear mixed model approach with time var…

2008

 ; The codling moth (Cydia pomonella) is responsible for most insecticide treatments in pear and apple orchards. In a context of reduction in pesticide use, we aim at better understanding factors that affect codling moth damage intensity. We modelled the link between the proportion of damaged fruits and both constant covariables (type of orchard: pear or apple, organic or not, with or without mating disruption) and time-varying covariables (weekly counts of adults and number of insecticide treatments). Observations were collected in 40 orchards in south-eastern France. We found that damage intensity increased with the number of adults trapped. An analysis of the random orchard effect indica…