Search results for "synthesi"
showing 4 items of 2904 documents
CVB3 VP1 interacts with MAT1 to inhibit cell proliferation by interfering with Cdk-activating kinase complex activity in CVB3-induced acute pancreati…
2021
Coxsackievirus B3 (CVB3) belongs to the genus Enterovirus of the family Picornaviridae and can cause acute acinar pancreatitis in adults. However, the molecular mechanisms of pathogenesis underlying CVB3-induced acute pancreatitis have remained unclear. In this study, we discovered that CVB3 capsid protein VP1 inhibited pancreatic cell proliferation and exerted strong cytopathic effects on HPAC cells. Through yeast two-hybrid, co-immunoprecipitation, and confocal microscopy, we show that Menage a trois 1 (MAT1), a subunit of the Cdk-Activating Kinase (CAK) complex involved in cell proliferation and transcription, is a novel interaction protein with CVB3 VP1. Moreover, CVB3 VP1 inhibited MAT…
Water in stereoselective organocatalytic reactions
2009
In this review, recent advances in asymmetric organocatalytic reactions carried out with variable amounts of water, from substoichiometric to a large excess (reaction medium), are discussed. We also summarize several proposed mechanisms for the different possibilities of the action of water both in the increased activity of the catalyst and in the asymmetric induction. Finally, the application of this catalytic methodology to the enantioselective synthesis of valuable compounds through enamine or iminium catalysis is presented.
Synteza i właściwości fizykochemiczne ftalocyjaniny manganu
2017
Ftalocyjaniny to organiczne związki chemiczne, które uzyskuje się jedynie na drodze syntezy chemicznej. Stanowią one jednak analogi strukturalne porfiryn, które naturalnie występują w przyrodzie, m.in. w takich cząsteczkach jak witamina B12 czy chlorofil. Obszerne badania dotyczące kompleksów ftalocyjanin wynikają z budowy tych związków, ponieważ cząsteczkę ftalocyjaniny można modyfikować na bardzo wiele sposobów. Wpływa to na różnorodność zastosowań ftalocyjanin, m.in. w urządzeniach elektronicznych, fotowoltaicznych, jako fotosensiblilizatory, barwniki i pigmenty. Kompleksy ftalocyjanin z takimi metalami jak mangan czy kobalt są intensywnie badane ze względu na ich interesujące właściwośc…
Desymmetrization of Prochiral Cyclobutanones via Nitrogen Insertion: A Concise Route to Chiral γ‐Lactams
2021
Abstract Asymmetric access to γ‐lactams is achieved via a cyclobutanone ring expansion using widely available (1S,2R)‐1‐amino‐2‐indanol for chiral induction. Mechanistic analysis of the key N,O‐ketal rearrangement reveals a Curtin–Hammett scenario, which enables a downstream stereoinduction (up to 88:12 dr) and is corroborated by spectroscopic, crystallographic, and computational studies. In combination with an easy deprotection protocol, this operationally simple sequence allows the synthesis of a range of optically pure γ‐lactams, including those bearing all‐carbon quaternary stereocenters. In addition, the formal synthesis of drug molecules baclofen, brivaracetam, and pregabalin further …