Search results for "t3b"
showing 3 items of 3 documents
Epigenetic dysregulation in the developing Down syndrome cortex
2016
Using Illumina 450K arrays, 1.85% of all analyzed CpG sites were significantly hypermethylated and 0.31% hypomethylated in fetal Down syndrome (DS) cortex throughout the genome. The methylation changes on chromosome 21 appeared to be balanced between hypo- and hyper-methylation, whereas, consistent with prior reports, all other chromosomes showed 3–11 times more hyper- than hypo-methylated sites. Reduced NRSF/REST expression due to upregulation of DYRK1A (on chromosome 21q22.13) and methylation of REST binding sites during early developmental stages may contribute to this genome-wide excess of hypermethylated sites. Upregulation of DNMT3L (on chromosome 21q22.4) could lead to de novo methyl…
Epigenetic Mechanisms as Key Regulators in Disease
2016
Epigenetics is a rapidly growing field of research which studies the changes in the gene expression that do not involve changes in the nucleotide sequence. The cellular metabolism is directly connected to epigenetic regulation through the inflow of different metabolites such as S-adenosylmethionine, acetyl-CoA, and α-ketoglutarate among others, which serve as substrates or cofactors for chromatin-modifying enzymes. These metabolites define how our lifestyle (i.e., nutrition, physical activity, and other healthy behaviors) acts on gene expression by epigenetic mechanisms. Therefore, proper coordination between components of the epigenetic machineries is essential for the correct control of t…
Análisis dosimétrico de la braquiterapia de alta tasa en pacientes con cáncer de próstata con afectación de vesículas seminales (T3b)
2015
La cobertura de las vesículas seminales en el implante de Braquiterapia Alta Tasa como sobreimpresión de dosis (boost), en pacientes de alto riesgo con afectación de vesículas seminales, no es un impedimento para lograr una dosimetría adecuada en el paciente, en comparación con el grupo de pacientes de alto riego sin afectación de vesículas seminales. Se podría plantear por tanto, una escalada de dosis en este grupo de pacientes. Objetivos : Demostrar que los parámetros dosimétricos estudiados en nuestro estudio son equivalentes en los dos grupos de pacientes de alto riesgo comparados (según presenten o no afectación de vesículas seminales), es decir, sobreimpresión de dosis con 15 Gy (alto…