Search results for "tail"
showing 10 items of 702 documents
Hyperforin Potentiates Antidepressant-Like Activity of Lanicemine in Mice
2018
International audience; N-methyl-D-aspartate receptor (NMDAR) modulators induce rapid and sustained antidepressant like-activity in rodents through a molecular mechanism of action that involves the activation of Ca2+ dependent signaling pathways. Moreover, ketamine, a global NMDAR antagonist is a potent, novel, and atypical drug that has been successfully used to treat major depressive disorder (MDD). However, because ketamine evokes unwanted side effects, alternative strategies have been developed for the treatment of depression. The objective of the present study was to determine the antidepressant effects of either a single dose of hyperforin or lanicemine vs. their combined effects in m…
2018
There are two important gaps of knowledge in depression treatment, namely the lack of biomarkers predicting response to antidepressants and the limited knowledge of the molecular mechanisms underlying clinical improvement. However, individually tailored treatment strategies and individualized prescription are greatly needed given the huge socio-economic burden of depression, the latency until clinical improvement can be observed and the response variability to a particular compound. Still, individual patient-level antidepressant treatment outcomes are highly unpredictable. In contrast to other therapeutic areas and despite tremendous efforts during the past years, the genomics era so far ha…
Genome-wide scan of fat-tail sheep identifies signals of selection for fat deposition and adaptation
2018
Fat tail in sheep represents a valuable energy reserve for facing future climate changes. The identification of genes with a role in the fat-tail phenotype may contribute to understanding the physiology of fat deposition and the mechanisms of adaptation. Genotypic data obtained with the OvineSNP50K array in 13 thin-tail sheep breeds from Italy were used to identify selection signatures of fat tail through pairwise thin- versus fat-tail sheep breed comparisons, with the following fat-tail breeds of the Mediterranean area: two unique Italian fat-tail breeds (Barbaresca and Laticauda), a Barbary sheep breed from Libya, Ossimi breed from Egypt, Cyprus Fat-Tail and Chios from the Greek islands …
Correction
2019
ABSTRACT During gastrulation, embryonic cells become specified into distinct germ layers. In mouse, this continues throughout somitogenesis from a population of bipotent stem cells called neuromesodermal progenitors (NMps). However, the degree of self-renewal associated with NMps in the fast-developing zebrafish embryo is unclear. Using a genetic clone-tracing method, we labelled early embryonic progenitors and found a strong clonal similarity between spinal cord and mesoderm tissues. We followed individual cell lineages using light-sheet imaging, revealing a common neuromesodermal lineage contribution to a subset of spinal cord tissue across the anterior-posterior body axis. An initial pop…
Guía para la incorporación de la perspectiva de género en la docencia en Sociología, Economía y Ciencias Políticas
2019
Sociology has constructed a male worldview that entails a biased interpretation of social reality. For its part, the traditional economy has made invisible the dependence of the commercial sphere of the domestic sphere. And in the field of political science, we also find many gender biases in basic concepts such as justice, equality or citizenship. This article, based on the work done by the authors in the Guia per a una docència universitària amb perspectiva de gènere de Sociologia, Economia i Ciència Política, offers some proposals, teaching resources and consultation tools to introduce the gender perspective in teaching, knowledge transfer and research in these disciplines.
Reform, revolution, riot? : transnational Nordic Sixties in the radical press, c. 1958-1968
2021
Mental Health Status of Healthcare Workers During the COVID-19 Outbreak
2021
Background: The COVID-19 pandemic is a massive health crisis that has exerted enormous physical and psychological pressure. Mental healthcare for healthcare workers (HCWs) should receive serious consideration. This study served to determine the mental-health outcomes of 1,556 HCWs from 45 countries who participated in the COVID-19 IMPACT project, and to examine the predictors of the outcomes during the first pandemic wave. Methods: Outcomes assessed were self-reported perceived stress, depression symptom, and sleep changes. The predictors examined included sociodemographic factors and perceived social support. Results: The results demonstrated that half of the HCWs had moderate levels of pe…
"Table 2" of "Measurement of dielectron production in central Pb-Pb collisions at $\sqrt{{\textit{s}}_{\mathrm{NN}}}$ = 2.76 TeV"
2018
Data-to-cocktail ratio. Statistical uncertainties are represented by vertical bars and systematic uncertainties by boxes.
"Table 3" of "Measurement of dielectron production in central Pb-Pb collisions at $\sqrt{{\textit{s}}_{\mathrm{NN}}}$ = 2.76 TeV"
2018
Dielectron invariant-mass spectrum divided by the hadronic cocktail without the contribution from the vacuum $\rho^{0}$. The statistical and systematic uncertainties of data are represented by vertical bars and boxes.
Suomen tiedontuotannon regiimi : yksi vai monta?
2021
Poliittisen talouden tutkimuksessa tapahtui 1990-luvulla niin kutsuttu ideakäänne. Viimeisen reilun vuosikymmenen aikana on alettu systemaattisesti tutkia ideoiden tuotantoa ja kanavointia poliittis-taloudelliseen päätöksentekoon. Vertailevan poliittisen talouden tutkimuksen piirissä on kehitetty tiedontuotannon regiimin teoria, joka tarkastelee tiedontuotannon institutionaalisia ja organisatorisia koneistoja, jotka tuottavat ideoita ja asiantuntijatietoa poliittis-taloudellista päätöksentekoa varten. Tämä artikkeli esittelee ja problematisoi tiedontuotannon regiimien tutkimusta. Artikkeli problematisoi tutkimuksen taustaoletusta regiimiin kuuluvien tiedontuottajien muodostaman organisaatio…