Search results for "talk"

Myeloid dendritic cell: From sentinel of immunity to key player of peripheral tolerance?

2009

Myeloid dendritic cells (DC) are "sentinels" of immunity, ideally positioned throughout the body gateways and equipped with unique properties to transport antigens from the periphery to lymphoid tissues. They are professional antigen-presenting cells transmitting incoming infectious signals to T cells, the key players of adaptive immunity. For induction of effective antigen-specific T-cell immunity, crosstalk of DC and naive T cells is mandatory. However, besides this essential immunostimulatory function of DC, consolidated findings from the DC research field in the last 10 years have shown that DC have an additional important function. They act as pivotal players in the peripheral toleranc…

Extracellular Membrane Vesicles as Vehicles for Brain Cell-to-Cell Interactions in Physiological as well as Pathological Conditions.

2015

Extracellular vesicles are involved in a great variety of physiological events occurring in the nervous system, such as cross talk among neurons and glial cells in synapse development and function, integrated neuronal plasticity, neuronal-glial metabolic exchanges, and synthesis and dynamic renewal of myelin. Many of these EV-mediated processes depend on the exchange of proteins, mRNAs, and noncoding RNAs, including miRNAs, which occurs among glial and neuronal cells. In addition, production and exchange of EVs can be modified under pathological conditions, such as brain cancer and neurodegeneration. Like other cancer cells, brain tumours can use EVs to secrete factors, which allow escaping…

Early life adversity targets the transcriptional signature of hippocampal NG2+ glia and affects voltage gated sodium (Nav) channels properties

2021

The precise mechanisms underlying the detrimental effects of early life adversity (ELA) on adult mental health remain still elusive. To date, most studies have exclusively targeted neuronal populations and not considered neuron-glia crosstalk as a crucially important element for the integrity of stress-related brain function. Here, we have investigated the impact of ELA, in the form of a limited bedding and nesting material (LBN) paradigm, on a glial subpopulation with unique properties in brain homeostasis, the NG2+ cells. First, we have established a link between maternal behavior, activation of the offspring's stress response and heterogeneity in the outcome to LBN manipulation. We furth…

Low-energy (anti)neutrino physics with Borexino: Neutrinos from the primary proton-proton fusion process in the Sun

2014

The Sun is fueled by a series of nuclear reactions that produce the energy that makes it shine. The primary reaction is the fusion of two protons into a deuteron, a positron and a neutrino. These neutrinos constitute the vast majority of neutrinos reaching Earth, providing us with key information about what goes on at the core of our star. Several experiments have now confirmed the observation of neutrino oscillations by detecting neutrinos from secondary nuclear processes in the Sun; this is the first direct spectral measurement of the neutrinos from the keystone proton-proton fusion. This observation is a crucial step towards the completion of the spectroscopy of pp-chain neutrinos, as we…

Change Talk in Hospital Management Groups

2020

Recent national healthcare reforms have resulted in many changes to healthcare organizations. When social realities are enacted in social interactions, changes also occur in communication through discourses. In public hospitals, middle management groups form one important platform for change talk. This study aimed to identify and understand how change talk emerges in management group meetings. Data were collected from 10 hospital meetings, and change-related interactions were explored by analyzing sensemaking and positioning. In the data, change talk took three forms: collaboration, control and confrontation. These forms consisted of change discourses (change as a possibility, concealed cha…

Short distance neutrino oscillations with Borexino

2014

International audience; The Borexino detector has convincingly shown its outstanding performances in the low energy, sub-MeV regime through its unprecedented accomplishments in the solar and geo-neutrinos detection. These performances make it the ideal tool to accomplish a state-of-the-art experiment able to test unambiguously the long-standing issue of the existence of a sterile neutrino, as suggested by the several anomalous results accumulated over the past two decades, i.e. the outputs of the LSND and Miniboone experiments, the results of the source calibration of the two Gallium solar neutrino experiments, and the recently hinted reactor anomaly. The SOX project will exploit two source…

Sezioni Unite Scenari 2016

2016

Analisi delle descisioni delle Sezioni Unite in tema di: notifica alla persona offesa nei procedimenti per stalking, di inammissibilità del ricorso per cassazione, di procura speciale del difensore nei casi di rinuncia all'impugnazione

The Crosstalk Between Signaling Pathways and Cancer Metabolism in Colorectal Cancer.

2021

Colorectal cancer (CRC) is one of the most frequently diagnosed cancers worldwide. Metabolic reprogramming represents an important cancer hallmark in CRC. Reprogramming core metabolic pathways in cancer cells, such as glycolysis, glutaminolysis, oxidative phosphorylation, and lipid metabolism, is essential to increase energy production and biosynthesis of precursors required to support tumor initiation and progression. Accumulating evidence demonstrates that activation of oncogenes and loss of tumor suppressor genes regulate metabolic reprogramming through the downstream signaling pathways. Protein kinases, such as AKT and c-MYC, are the integral components that facilitate the crosstalk bet…

Molecular Mechanisms of the Crosstalk Between Mitochondrial and NADPH Oxidase Derived Reactive Oxygen Species in White Blood Cells - Implications for…

2012

Learner-generated drawings in physics education

2013

Different kinds of visual representations, such as graphs and drawings are important in education but especially in science education. Little attention is paid especially to drawings. Students are required to examine drawings and assimilate the information conveyed by them but not much attention is paid to the students’ own drawings. Arguments can be made for the importance of learner-generated drawings in science education. The subject of this thesis is the use of learner-generated drawings in physics education. A study was conducted to study the use of learner-generated drawings as a tool for meaning-making. The study involved 36 upper secondary school students who were given a drawing as…