Search results for "target"

First measurement of the |t|-dependence of coherent J/ψ photonuclear production

2021

The first measurement of the dependence on $|t|$, the square of the momentum transferred between the incoming and outgoing target nucleus, of coherent J/ψ photoproduction is presented. The data were measured with the ALICE detector in ultra-peripheral Pb-Pb collisions at a centre-of-mass energy per nucleon pair $\sqrt{s_{\rm NN}} = 5.02$ TeV with the J/$\psi$ produced in the central rapidity region $|y| < 0.8$, which corresponds to the small Bjorken-$x$ range $(0.3 − 1.4) \times 10 ^{−3}$. The measured $|t|$-dependence is not described by computations based only on the Pb nuclear form factor, while the photonuclear cross section is better reproduced by models including shadowing according t…

Review of carbon emissions offsetting guidelines using instructional criteria

2023

Abstract Purpose Carbon offsetting is one of the tools that companies can use to achieve their climate targets. The ability of a company to offset its emissions successfully depends on the availability and quality of guidance on the subject. This study explores how well existing offsetting guidelines equip corporations to achieve successful emissions offsetting. Methods Instructional criteria were developed and used to evaluate seven guidelines. The contents of each guideline were assessed based on how they instruct a company to achieve emissions offsetting that fulfills five criteria for appropriate offsetting: target affiliation, Paris compatibility, effectiveness, prioritizing removals, …

Switching from Aromatase Inhibitors to Dual Targeting Flavonoid-Based Compounds for Breast Cancer Treatment

2023

Despite the significant outcomes attained by scientific research, breast cancer (BC) still represents the second leading cause of death in women. Estrogen receptor-positive (ER+) BC accounts for the majority of diagnosed BCs, highlighting the disruption of estrogenic signalling as target for first-line treatment. This goal is presently pursued by inhibiting aromatase (AR) enzyme or by modulating Estrogen Receptor (ER) α. An appealing strategy for fighting BC and reducing side effects and resistance issues may lie in the design of multifunctional compounds able to simultaneously target AR and ER. In this paper, previously reported flavonoid-related potent AR inhibitors were suitably modified…

Unmixing methods in novel applications of spectral imaging

2014

Effects of B-Cell Lymphoma on the Immune System and Immune Recovery after Treatment: The Paradigm of Targeted Therapy

2022

B-cell lymphoma and lymphoproliferative diseases represent a heterogeneous and complex group of neoplasms that are accompanied by a broad range of immune regulatory disorder phenotypes. Clinical features of autoimmunity, hyperinflammation, immunodeficiency and infection can variously dominate, depending on the immune pathway most involved. Immunological imbalance can play a role in lymphomagenesis, also supporting the progression of the disease, while on the other hand, lymphoma acts on the immune system to weaken immunosurveillance and facilitate immunoevasion. Therefore, the modulation of immunity can have a profound effect on disease progression or resolution, which makes the immune syst…

The Design and Impacts of Individual Sanctions: Evidence From Elites in Côte d’Ivoire and Zimbabwe

2022

Since the 1990s, sanctions senders like the European Union, the United States, and the United Nations have been imposing visa bans and asset freezes on individuals as a key element of their sanctions packages. Notwithstanding the growing centrality that individual sanctions have acquired in international sanctions practice, little is known about the impact of sanctions listings on designees. Some researchers have scrutinised targeting choices, while others have explored the effects of sanctions on designees. However, no study has yet examined the fit between targeting choices and impacts on designees. First, we interrogate the theory of targeted sanctions to identify the expectations that i…

Sviluppo di nanocarriers per il “drug release” controllato di biomolecole nella terapia antitumorale

2014

Una nuova generazione di nanogels (NGs) in poly(N-vinyl pyrrolidone) (PVP) è stata ottenuta mediante beta–irraggiamento (e-beam) ad alta energia mediante elettroni accelerati, che permette in tempi brevi la reticolazione di polimeri in soluzione acquosa, utilizzando acceleratori di particelle lineari. Oltre al controllo dimensionale, l’aspetto innovativo di tale tecnica è la possibilità di ottenere nanogels sterili, la cui funzionalizzazione di superficie avviene in un unico step. Inizialmente, è stata provata la loro biocompatibilità e non genotossicità in sistemi biologici, caratteristiche fondamentali per la loro applicazione in campo biomedico. Inoltre, sono stati messi a punto dei prot…

Dimensiunea Economică a Strategiei Europa 2020

2012

The aim of the paper is to present the economic dimension of the Europe 2020 strategy. The new strategy of European Union, was launched on 3 march 2010, as a response for economic crisis. Considerated as a new agenda for economic problem, continue, as Lisbon strategy did, to offer a new instrument to boost growth and jobs in all EU’s country. It contains 3 key priorities: smart growth, sustainable growth and inclusive growth. The economic dimension identify 3 headline targets that EU must achive them until 2020: 75 % of the population aged 20-64 should be employed; 3% of the EU's GDP should be invested in R&D and „20/20/20” climate/energy targets. The two primary research objective are: 1. …

First operational experience of HIE-ISOLDE

2016

The High Intensity and Energy ISOLDE project (HIE-ISOLDE)* is a major upgrade of the ISOLDE facility at CERN. The energy range of the post-accelerator will be extended from 2.85 MeV/u to 9.3 MeV/u for beams with A/q = 4.5 (and to 14.3 MeV/u for A/q = 2.5) once all the cryomodules of the superconducting accelerator are in place. The project has been divided into different phases, the first of which (phase 1a) finished in October 2015 after the hardware and beam commissioning were completed**. The physics campaign followed with the delivery of both radioactive and stable beams to two different experimental stations. The characteristics of the beams (energies, intensities, time structure and b…

Research to engage voices on the ground in educational development

2014

The article discusses how a variety of qualitative methods could be used for investigating the engagement of the voices on the ground, where the change is expected to happen. It also reviews how qualitative research approaches involve students and teachers, the so-called “target groups” of educational development, as subjects, rather than objects. The qualitative methods are presented here for their potential in engaging the voices on the ground. Actor-centred inquiry and participatory action research consist of data collected, analysed and reported, in collaboration between researchers and the research subjects. Enabling the subjects as autonomous actors to take part in the analysis of the…