Search results for "target"
showing 10 items of 1196 documents
Plasma PLTP (phospholipid-transfer protein): an emerging role in ‘reverse lipopolysaccharide transport’ and innate immunity
2011
Plasma PLTP (phospholipid-transfer protein) is a member of the lipid transfer/LBP [LPS (lipopolysaccharide)-binding protein] family, which constitutes a superfamily of genes together with the short and long PLUNC (palate, lung and nasal epithelium clone) proteins. Although PLTP was studied initially for its involvement in the metabolism of HDL (high-density lipoproteins) and reverse cholesterol transport (i.e. the metabolic pathway through which cholesterol excess can be transported from peripheral tissues back to the liver for excretion in the bile), it displays a number of additional biological properties. In particular, PLTP can modulate the lipoprotein association and metabolism of LPS …
Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis.
2020
In the past few decades, polymeric nanocarriers have been recognized as promising tools and have gained attention from researchers for their potential to efficiently deliver bioactive compounds, including drugs, proteins, genes, nucleic acids, etc., in pharmaceutical and biomedical applications. Remarkably, these polymeric nanocarriers could be further modified as stimuli-responsive systems based on the mechanism of triggered release, i.e., response to a specific stimulus, either endogenous (pH, enzymes, temperature, redox values, hypoxia, glucose levels) or exogenous (light, magnetism, ultrasound, electrical pulses) for the effective biodistribution and controlled release of drugs or genes…
A comparison between the chemical behaviour of lead-gold and lead-bismuth eutectics towards 316L stainless steel
2013
Radiochimica acta, 101 (10)
La transposición creativa de Volpone de J. Romain y M. Tourneur
2016
We are well aware that, no matter how valuable a text may be, its afterlife in other cultural and linguistic contexts is heavily dependent on the translator’s ability to meet the needs and expectations of its target audience. This is precisely what French screenwriter Jules Romains and film director Maurice Tourneur did when adapting Jonson’s Volpone [1940] for the new medium at the advent of sound films. It is the aim of this article to cast light on their creative transposition of Ben Jonson’s theatrical masterpiece. Keywords : Romains; Tourneur; Volpone ; creative transposition
Visual Representa of a Woman in the Semiotic Landscape of the Baltic States
2014
Linguistic landscape (LL) research of nine cities of the Baltic States shows that feminine discourse is of an essential significance in the public space. This is linguistically proved by feminine person’s names in ergonyms, also by female ergonyms and graffiti themes. However, there are multi-modal advertisements reflecting women and female items in the public space, and they are to be viewed from the perspective of the semiotic landscape. There are 294 photos reflecting a woman excerpted from the LL data base to describe visual images of a woman, focusing on the archetypes and concepts on woman’s role in society. There is a semiotic landscape research method, perception of a visual identit…
Liver fibrosis: Direct antifibrotic agents and targeted therapies
2018
Liver fibrosis and in particular cirrhosis are the major causes of morbidity and mortality of patients with chronic liver disease. Their prevention or reversal have become major endpoints in clinical trials with novel liver specific drugs. Remarkable progress has been made with therapies that efficiently address the cause of the underlying liver disease, as in chronic hepatitis B and C. Highly effective antiviral therapy can prevent progression or even induce reversal in the majority of patients, but such treatment remains elusive for the majority of liver patients with advanced alcoholic or nonalcoholic steatohepatitis, genetic or autoimmune liver diseases. Moreover, drugs that would speed…
The nonalcoholic steatohepatitis (NASH) drug development graveyard: established hurdles and planning for future success
2020
Contains fulltext : 229341.pdf (Publisher’s version ) (Open Access) INTRODUCTION: Numerous pharmacological compounds that target the different molecular targets involved in the pathobiology of nonalcoholic steatohepatitis (NASH) are currently in clinical testing. So far, there are no regulatory approvals. AREAS COVERED: This paper sheds light on the molecular pathways involved in NASH and the drugs targeting these pathways. We have identified 10 compounds whose clinical development program has been halted. Moreover, we explore early phase clinical trials and dissect the reasons for termination of development. EXPERT OPINION: The main goal of NASH pharmacotherapy is to halt or reverse hepati…
The antifibrotic potential of a sustained release formulation of a PDGF beta-receptor targeted rho kinase inhibitor
2019
Rho kinase activity in hepatic stellate cells (HSCs) is associated with activation, transformation and contraction of these cells, leading to extracellular matrix production and portal hypertension in liver cirrhosis. Inhibition of rho kinase activity can reduce these activities, but may also lead to side effects, for instance systemic hypotension. This can be circumvented by liver-specific delivery of a rho kinase inhibitor to effector cells. Therefore, we targeted the rho kinase inhibitor Y27632 to the key pathogenic cells in liver fibrosis, i.e. myofibroblasts including activated HSCs that highly express the PDGF beta-receptor, using the drug carrier pPB-MSA. This carrier consists of mou…
Targeted therapy of liver fibrosis/cirrhosis and its complications.
2011
Department of Pharmacokinetics, Toxicology, and Targeting, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands; Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA; Division of Molecular and Translational Medicine, Johannes Gutenberg University, Langenbeckstr. 1, 55131 Mainz, Germany
Learning a class of regular expressions via restricted subset queries
1992
A wide class of regular expressions non-representable as unions of “smaller” expressions is shown to be polynomial-time learnable via restricted subset queries from arbitrary representative examples “reflecting” the loop structure and a way the input example is obtained from the unknown expression. The corresponding subclass of regular expressions of loop depth at most 1 is shown to be learnable from representative examples via membership queries. A wide class of expressions with loops A+ of arbitrary loop depth is shown to be learnable via restricted subset queries from arbitrary examples.