Search results for "target"
showing 10 items of 1196 documents
Nanocapsules with specific targeting and release properties using miniemulsion polymerization.
2013
The field of application for nanosized materials ranges from mere technical purposes to a growing field of applications in biomedicine. Among the different techniques and processes to produce these materials for encapsulation of reporter molecules and drugs, the miniemulsion process has been proven to be highly adaptable to these specific needs.The review covers the recent developments in the field of miniemulsion as a very powerful technique for the formation of complex carriers for the encapsulation of different kinds of reporter molecule and drugs. The use of a wide variety of polymerization techniques in the miniemulsion process and possible utilization of a wide range of monomers as re…
Ionizing radiation-engineered nanogels as insulin nanocarriers for the development of a new strategy for the treatment of Alzheimer's disease
2016
A growing body of evidence shows the protective role of insulin in Alzheimer's disease (AD). A nanogel system (NG) to deliver insulin to the brain, as a tool for the development of a new therapy for Alzheimer's Disease (AD), is designed and synthetized. A carboxyl-functionalized poly(N-vinyl pyrrolidone) nanogel system produced by ionizing radiation is chosen as substrate for the covalent attachment of insulin or fluorescent molecules relevant for its characterization. Biocompatibility and hemocompatibility of the naked carrier is demonstrated. The insulin conjugated to the NG (NG-In) is protected by protease degradation and able to bind to insulin receptor (IR), as demonstrated by immunofl…
DNA Block Copolymer Micelles – A Combinatorial Tool for Cancer Nanotechnology
2008
Selective drug targeting of a specific organ or tissue is a challenging task. This holds especially true for chemotherapeutic cancer treatment because most of the available anticancer agents cannot distinguish between cancerous and healthy cells, leading to systemic toxicity and undesirable side effects. One effective approach to address this problem is the application of polymeric nanoparticles equipped with targeting units for tumor-specific delivery. For instance dendrimers, highly branched macromolecules, can be equipped with targeting units as well as with anticancer drugs because of their large number of surface functionalities. Amphiphilic block copolymers, which self-assemble in dil…
Start-up and shutdown thermomechanical transient analyses of the IFMIF European lithium target system
2014
In the framework of the current IFMIF Engineering Validation and Engineering Design Activities (IFMIF/EVEDA) phase, ENEA is responsible for the design of the European concept of the IFMIF lithium target system which foresees the possibility to periodically replace only the most irradiated and thus critical component (i.e., the backplate) while continuing to operate the rest of the target for a longer period (bayonet backplate concept). With the objective of evaluating the performances of the system in terms of temperature, stress and displacement fields evolution during start-up and shutdown phases, an uncoupled thermomechanical transient analysis has been performed in close collaboration w…
Hepatocyte-targeted fluorescent nanoparticles based on a polyaspartamide for potential theranostic applications
2015
Abstract Here, the synthesis of a galactosylated amphiphilic copolymer bearing rhodamine (RhB) moieties and its use for the preparation of polymeric fluorescent nanoparticles for potential applications in therapy and diagnosis are described. To do this, firstly, a fluorescent derivative of α,β-poly( N -2-hydroxyethyl)- d , l -aspartamide (PHEA) was synthesized by chemical reaction with RhB, and with polylactic acid (PLA), to obtain PHEA-RhB-PLA. Then, the derivatization of PHEA-RhB-PLA with GAL-PEG-NH 2 allows obtaining PHEA-RhB-PLA-PEG-GAL copolymer, with derivatization degrees in -PLA and -PEG-GAL equal to 1.9 mol% and 4.5 mol%, respectively. Starting from this copolymer, liver-targeted f…
Contactless Nanoparticle-Based Guiding of Cells by Controllable Magnetic Fields
2021
Peter Blümler,1 Ralf P Friedrich,2 Jorge Pereira,3 Olga Baun,1 Christoph Alexiou,2 Volker Mailänder3,4 1Institute of Physics, Johannes Gutenberg-University Mainz, Mainz, 55128, Germany; 2Department of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung-Professorship, Universitätsklinikum Erlangen, Erlangen, 91054, Germany; 3Department of Physical Chemistry, Max Planck Institute for Polymer Research, Mainz, 55128, Germany; 4Department of Dermatology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, 55131, GermanyCorrespondence: Peter Blümle…
Variable magnification digital in-line holographic microscopy
2019
We present a new layout providing different magnifications and resolution capabilities in lensless imaging by using an electrically tunable lens (ETL). Experimental validation is reported using a resolution test target and prostate cancer cells.
The European contribution to the development and validation activities for the design of IFMIF lithium facility
2013
The International Fusion Materials Irradiation Facility (IFMIF) is an accelerator-driven intense neutron source where candidate materials for fusion reactors will be tested and validated. The high energy neutron flux is produced by means of two deuteron beams (total current of 250 mA, energy of 40 MeV) that strikes a liquid lithium target circulating in a lithium loop of IFMIF plant. The European (EU) contribution to the development of the lithium facility comprises five procurement packages, as follow: (1) participation to the experimental activities of the EVEDA lithium test loop in Oarai (Japan); (2) study aimed at evaluating the corrosion and erosion phenomena, promoted by lithium, for …
Competencies in ICT of teachers and their relation to the use of the technological resources
2010
Over the past decade the Information and Communication Technologies (ICT) have represented a transformation of education policies that have entailed important investments. However, the teacher, as a key element in the integration process of ICT, still does not feel trusted this process. One of the most outstanding causes of this deficit confidence is the lack of teaching staff competence in the ICT. Therefore, the aim of this paper is a study of the teachers’ competence on ICT and their relation to the use being made of these technologies, both professional-personal and with their students. For it a survey design has been used. The target population constitutes the teaching staff of centers…
Targeted tumor imaging of anti-CD20-polymeric nanoparticles developed for the diagnosis of B-cell malignancies
2015
Sara Capolla,1 Chiara Garrovo,2 Sonia Zorzet,1 Andrea Lorenzon,3 Enrico Rampazzo,4 Ruben Spretz,5 Gabriele Pozzato,6 Luis Núñez,7 Claudio Tripodo,8 Paolo Macor,1,9 Stefania Biffi2 1Department of Life Sciences, University of Trieste, 2Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”, Trieste, 3Animal Care Unit, Cluster in Biomedicine (CBM scrl), Trieste, Italy; 4Department of Chemistry “G. Ciamician”, University of Bologna, Bologna, Italy; 5LNK Chemsolutions LLC, Lincoln, NE, USA; 6Department of Medical, Surgery and Health Sciences, University of Trieste, Trieste, Italy; 7Bio-Target, Inc., University of C…