Search results for "taso"
showing 10 items of 271 documents
A rare disease and education : Neurofibromatosis type 1 decreases educational attainment
2021
Rare heritable syndromes may affect educational attainment. Here, we study education in neurofibromatosis 1 (NF1) that is associated with multifaceted medical, social and cognitive consequences. Educational attainment in the Finnish population‐based cohort of 1408 individuals with verified NF1 was compared with matched controls using Cox proportional hazards model with delayed entry and competing risk for death. Moreover, models accounting for the effects of cancer at age 15–30 years, parental NF1 and developmental disorders were constructed. Overall, the attainment of secondary education was reduced in individuals with NF1 compared to controls (hazard ratio 0.83, 95%CI 0.74–0.92). History …
Extracellular Vesicles in Human Reproduction in Health and Disease.
2017
Extensive evidence suggests that the release of membrane-enclosed compartments, more commonly known as extracellular vesicles (EVs), is a potent newly identified mechanism of cell-to-cell communication both in normal physiology and in pathological conditions. This review presents evidence about the formation and release of different EVs, their definitive markers and cargo content in reproductive physiological processes, and their capacity to convey information between cells through the transfer of functional protein and genetic information to alter phenotype and function of recipient cells associated with reproductive biology. In the male reproductive tract, epididymosomes and prostasomes p…
Does education protect against depression? Evidence from the Young Finns Study using Mendelian randomization
2018
Using participants (N = 1733) drawn from the nationally representative longitudinal Young Finns Study (YFS) we estimate the effect of education on depressive symptoms. In 2007, when the participants were between 30 and 45 years old, they reported their depressive symptoms using a revised version of Beck's Depression Inventory. Education was measured using register information on the highest completed level of education in 2007, which was converted to years of education. To identify a causal relationship between education and depressive symptoms we use an instrumental variables approach (Mendelian randomization, MR) with a genetic risk score as an instrument for years of education. The genet…
Dexamethasone Preconditioning in Cardiac Procedures Reduces Decreased Antithrombin Activity and Is Associated to Beneficial Outcomes: Role of Endothe…
2018
13 páginas, 6 figuras, 2 tablas.
Muhammad Alin nousu poliittiskulttuuriseksi ikoniksi : yhteiskunnallisten taustatekijöiden liikuntasosiologinen analyysi
2015
Urheiluhistorian merkkihenkilöistä puhuttaessa yksi nimi nousee usein ylitse muiden. Nyrkkeilijä Muhammad Ali on olympiavoittaja sekä kolminkertainen maailmanmestari. Alin urheilulliset saavutukset ja meriitit kuitenkin kalpenevat hänen yhteiskunnallisten saavutustensa rinnalla. 1960- ja 1970-luvuilla Muhammad Alista tuli enemmän kuin pelkkä urheilija. Hänestä tuli poliittiskulttuurinen ikoni ja kokonaisen aikakauden kuvajainen. Hänestä tuli myyttinen symboli, jonka tapahtumarikas taival on kiehtonut tutkijoita, toimittajia, historian harrastajia, penkkiurheilijoita sekä viihteentekijöitä jo yli viidenkymmenen vuoden ajan. Muhammad Aliin tietyllä tapaa tiivistyy liikunnan yhteiskuntatieteid…
Diskurssianalyysi kantasolututkimusta koskevista teksteistä vuosina 2001-2013
2013
Tämän tutkielman tarkoitus on perehtyä kantasolututkimuksen bioetiikkaan ja diskurssianalyysin avulla selvittää miten kantasolututkimuksesta puhuvat tiedetaustaiset sekä uskontaustaiset henkilöt ja miten diskurssit eroavat toisistaan. Empiirisenä aineistona toimivat erinäiset tieteelliset ja uskonnolliset julkaisut (n=30). Metadiskursseina toimivat lääketieteellinen eli bioeettinen sekä uskonnolliset diskurssit. Lääketieteellisestä diskurssista paljastui myös sairauksien parantamisen-, tutkimustyön-, lakiin pohjautuvan-, taloudellisen sekä uhkien aladiskurssit kun uskonnollisessa ne olivat kritisoiva, poliittinen ja taloudellinen. Tutkimuksen metodologiset ratkaisut pohjautuivat sekä perint…
Efficacy of mometasone furoate microemulsion in the treatment of erosive-ulcerative oral lichen planus: pilot study
2004
Background: Oral lichen planus (OLP) is a frequent immunological chronic disease, having different clinical forms: asymptomatic and symptomatic. Symptomatic OLP has been palliated with topical corticosteroids with different levels of efficacy and safety. The purpose of this pilot phase II clinical trial was to determine the efficacy of mometasone furoate microemulsion upon the symptoms and signs of erosive-ulcerative OLP. Methods: Forty-nine patients with clinical and histologically confirmed erosive-ulcerative OLP were enrolled in this study (36 women and 13 men). Their average age was 56.4 years (from 28 to 78). The treatment consisted of 0.1% mometasone furoate microemulsion mouthwash …
Education Leads to a More Physically Active Lifestyle : Evidence Based on Mendelian Randomization
2019
Physical inactivity is a major health risk worldwide. Observational studies suggest that higher education is positively related to physical activity, but it is not clear whether this relationship constitutes a causal effect. Using participants (N = 1651) drawn from the Cardiovascular Risk in Young Finns Study linked to nationwide administrative data from Statistics Finland, this study examined whether educational attainment, measured by years of education, is related to adulthood physical activity in terms of overall physical activity, weekly hours of intensive activity, total steps per day, and aerobic steps per day. We employed ordinary least squares (OLS) models and extended the analysis…
Participation rates by educational levels have diverged during 25 years in Finnish health examination surveys
2018
Background Declining participation rates in health examination surveys may impair the representativeness of surveys and introduce bias into the comparison of results between population groups if participation rates differ between them. Changes in the characteristics of non-participants over time may also limit comparability with earlier surveys. Methods We studied the association of socio-economic position with participation, and its changes over the past 25 years. Occupational class and educational level are used as indicators of socio-economic position. Data from six cross-sectional FINRISK surveys conducted between 1987 and 2012 in Finland were linked to national administrative registers…
Dose-Related Effect of Beclomethasone Dipropionate on Airway Responsiveness in Asthma
1990
The effects of twice daily inhaled beclomethasone dipropionate (BDP) at two dose levels (500 and 1,000 micrograms daily) on the airway responsiveness to inhaled histamine was evaluated by a randomized, single-blind, cross-over study in 10 patients with stable asthma. The 12-week study began with a 3-week run-in period of baseline treatment, which was continued unchanged throughout the study, and the two treatment periods were separated by a 3-week placebo period. Patients attended the laboratory every 3 weeks for spirometry and histamine inhalation tests to determine the provocative concentration of histamine causing a 20% fall in forced expiratory volume in 1 s (PC20 of FEV1). There was a …