Search results for "taudit"
showing 10 items of 347 documents
Rational and design of the European randomized Optical Coherence Tomography Optimized Bifurcation Event Reduction Trial (OCTOBER)
2018
Background Percutaneous coronary intervention in complex bifurcation lesions is prone to suboptimal implantation results and is associated with increased risk of subsequent clinical events. Angiographic ambiguity is high during bifurcation stenting, but it is unknown if procedural guidance by intravascular optical coherence tomography (OCT) improves clinical outcome. Methods and design OCTOBER is a randomized, investigator-initiated, multicenter trial aimed to show superiority of OCT-guided stent implantation compared to standard angiographic-guided implantation in bifurcation lesions. The primary outcome measure is a 2-year composite end point of cardiac death, target lesion myocardial inf…
European evidence-based recommendations for clinical assessment of upper limb in neurorehabilitation (CAULIN): data synthesis from systematic reviews…
2021
Abstract Background Technology-supported rehabilitation can help alleviate the increasing need for cost-effective rehabilitation of neurological conditions, but use in clinical practice remains limited. Agreement on a core set of reliable, valid and accessible outcome measures to assess rehabilitation outcomes is needed to generate strong evidence about effectiveness of rehabilitation approaches, including technologies. This paper collates and synthesizes a core set from multiple sources; combining existing evidence, clinical practice guidelines and expert consensus into European recommendations for Clinical Assessment of Upper Limb In Neurorehabilitation (CAULIN). Methods Data from systema…
Does the freshwater mussel Anodonta anatina remove the fish pathogen Flavobacterium columnare from water?
2021
AbstractGlobal decline of freshwater mussels (Unionoida) is threatening biodiversity and the essential ecosystem services that mussels provide. As filter-feeding organisms, freshwater mussels remove phytoplankton and suspended particles from the water. By filtering bacteria, freshwater mussels also decrease pathogen loads in the water. The objective of this study was to evaluate whether the common freshwater bivalve Anodonta anatina (duck mussel) could remove the bacterial fish pathogen Flavobacterium columnare from the water. Mussels reduced bacteria in both of the two experiments performed, so that the bacterial concentration at the end of the 96-h monitoring in mussel treatments was only…
Entisten suomalaisten huippu-urheilijoiden alkoholinkäyttö ja alkoholisairauksien riski
2016
Kontro, T. 2016. Entisten suomalaisten huippu-urheilijoiden alkoholinkäyttö ja alkoholisairauksien riski. Terveystieteiden laitos, Jyväskylän yliopisto, liikuntalääketieteen pro gradu -tutkielma, 69 s., 7 liitettä. Tutkimuksen tausta ja tarkoitus: Haitallinen alkoholinkäyttö on globaali ongelma. Myös entisten huippu-urheilijoiden alkoholinkäytöstä on keskusteltu mediassa paljon, mutta tieteellistä näyttöä aiheesta ei juurikaan ole olemassa. Tämän tutkimuksen tarkoituksena oli tutkia aiemman kilpaurheilu-uran ja alkoholisairauksien välistä yhteyttä sekä alkoholinkäyttöä eri urheilulajiryhmissä ja verrokeilla. Lisäksi haluttiin selvittää eri taustamuuttujien, kuten kilpa- ja kuntourheiluaktiv…
Birth weight, adult weight, and cardiovascular biomarkers : Evidence from the Cardiovascular Young Finns Study
2021
This study quantifies the causal effect of birth weight on cardiovascular biomarkers in adulthood using the Cardiovascular Risk in Young Finns Study (YFS). We apply a multivariable Mendelian randomization (MVMR) method that provides a novel approach to improve inference in causal analysis based on a mediation framework. The results show that birth weight is linked to triglyceride levels (β = −0.294; 95% CI [−0.591, 0.003]) but not to low-density lipoprotein (LDL) cholesterol levels (β = 0.007; 95% CI [−0.168, 0.183]). The total effect of birth weight on triglyceride levels is partly offset by a mediation pathway linking birth weight to adult BMI (β = 0.111; 95% CI [−0.013, 0.234]). The nega…
NAD+ repletion with niacin counteracts cancer cachexia
2023
AbstractCachexia is a debilitating wasting syndrome and highly prevalent comorbidity in cancer patients. It manifests especially with energy and mitochondrial metabolism aberrations that promote tissue wasting. We recently identified nicotinamide adenine dinucleotide (NAD+) loss to associate with muscle mitochondrial dysfunction in cancer hosts. In this study we confirm that depletion of NAD+ and downregulation of Nrk2, an NAD+ biosynthetic enzyme, are common features of severe cachexia in different mouse models. Testing NAD+ repletion therapy in cachectic mice reveals that NAD+ precursor, vitamin B3 niacin, efficiently corrects tissue NAD+ levels, improves mitochondrial metabolism and amel…
Neglect, virtual reality and music therapy : A narrative review
2022
Liikuntaintervention vaikutus 3-7-vuotiaiden lasten fyysiseen aktiivisuuteen ja motorisiin taitoihin sekä fyysisen aktiivisuuden yhteys sydän- ja ver…
2005
Sääkslahti selvitti väitöskirjatutkimuksessaan runsaaseen ulkoliikuntaan kannustavan liikuntaohjelman vaikutuksia 3-7-vuotiaiden lasten liikunnan määrään ja perustaitoihin. Lisäksi hän tarkasteli liikunnan määrän ja laadun yhteyttä sepelvaltimotaudin riskitekijöihin.Lapset tarvitsevat liikuntaa kasvaakseen ja kehittyäkseen. Hyvin pitkään oletettiin, että lapset liikkuvat ja leikkivät riittävästi. 1990-luvun aikana erilaiset tietotekniset laitteet ja pelit alkoivat kilpailla lasten huomiosta ja ajankäytöstä. Hyvin suuri osa lasten ns. vapaista leikeistä on aikaisemmin ollut erilaisia kasvua ja kehitystä tukevia liikuntaleikkejä. 2000-luvun alussa tilanne kuitenkin on muuttunut. Ajankäytön mu…
The effects of technology-utilising rehabilitation on rehabilitees' physical activity: a prospective cohort study
2021
The aim of this study was to investigate the effects of technology-utilising rehabilitation on different intensities of physical activity (PA) and determine the explanatory factors of PA change. This was a prospective cohort study. Cardiac, musculoskeletal and vocational rehabilitees (N = 36) had 6 months of rehabilitation, which included guided training and counselling face-to-face as well as through distance technology. PA (total, light, moderate, vigorous) was measured by an activity tracker. Biopsychosocial questionnaires, waist circumference, PA measurements and m-coach activity were used to determine the factors that influence PA change. Technology-utilising rehabilitation improved li…
Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study…
2020
Background: Lynch syndrome is associated with an increased risk of colorectal cancer and with a broader spectrum of cancers, especially endometrial cancer. In 2011, our group reported long-term cancer outcomes (mean follow-up 55·7 months [SD 31·4]) for participants with Lynch syndrome enrolled into a randomised trial of daily aspirin versus placebo. This report completes the planned 10-year follow-up to allow a longer-term assessment of the effect of taking regular aspirin in this high-risk population. Methods: In the double-blind, randomised CAPP2 trial, 861 patients from 43 international centres worldwide (707 [82%] from Europe, 112 [13%] from Australasia, 38 [4%] from Africa, and four [<…