Search results for "taudit"

The difference in risk of chronic pulmonary disease morbidity and mortality between elite athletes and ordinary men in Finland

2020

Introduction: The impact of a history of competitive sports on later smoking behavior and occurrence of chronic pulmonary diseases is poorly known. We investigated how a history of elite level sports predicted later pulmonary disease morbidity and mortality. Methods: Chronic pulmonary disease incidence were assessed from national hospital and cause-of-death registers from 1970 to 2015 among Finnish male former elite athletes (n=2078) and matched controls (n=1453) alive in 1970 (mean age 45.0 years). Hazard ratios (HRs) were calculated by Cox proportional hazards model. In 1985, cohort members reported on their smoking habits, engagement in physical activity/sports and physician-diagnosed ch…

Hyvä varhaisaikuisuuden kestävyyskunto suojaa valtimoita 40 vuotta

2023

Cross-sectional associations between cardiorespiratory fitness and NMR-derived metabolic biomarkers in children : the PANIC study

2022

Objective: Cardiorespiratory fitness has been inversely associated with cardiovascular risk across the lifespan. Some studies in adults suggest that higher cardiorespiratory fitness is associated with cardioprotective metabolite profile, but the evidence in children is lacking. Therefore, we investigated the cross-sectional association of cardiorespiratory fitness with serum nuclear magnetic resonance derived metabolic biomarkers in children. Methods: A population sample of 450 children aged 6–8 years was examined. Cardiorespiratory fitness was assessed by a maximal exercise test on a cycle ergometer and quantified as maximal power output normalised for lean body mass assessed by dual-energ…

Peak oxygen uptake, ventilatory threshold, and arterial stiffness in adolescents

2018

Purpose To investigate the associations of peak oxygen uptake (V̇ O2peak) and V̇ O2 at ventilatory threshold (V̇ O2 at VT) with arterial stiffness in adolescents. Methods The participants were 55 adolescents (36 girls, 19 boys) aged 16–19 years. Aortic pulse wave velocity (PWVao) and augmentation index (AIx%) were measured by non-invasive oscillometric device from right brachial artery level. V̇ O2peak was directly measured during a maximal ramp test on a cycle ergometer. V̇ O2 at VT was determined using the equivalents for ventilation (V̇ E/V̇ CO2 and V̇ E/V̇ O2). V̇ O2peak and V̇ O2 at VT were normalised for body mass (BM) and lean mass (LM). Data were analysed using linear regression ana…

Rare variant analyses across multiethnic cohorts identify novel genes for refractive error

2023

Refractive error, measured here as mean spherical equivalent (SER), is a complex eye condition caused by both genetic and environmental factors. Individuals with strong positive or negative values of SER require spectacles or other approaches for vision correction. Common genetic risk factors have been identified by genome-wide association studies (GWAS), but a great part of the refractive error heritability is still missing. Some of this heritability may be explained by rare variants (minor allele frequency [MAF] ≤ 0.01.). We performed multiple gene-based association tests of mean Spherical Equivalent with rare variants in exome array data from the Consortium for Refractive Error and Myopi…

Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata

2023

Uterine leiomyomata (UL) are the most common tumours of the female genital tract and the primary cause of surgical removal of the uterus. Genetic factors contribute to UL susceptibility. To add understanding to the heritable genetic risk factors, we conduct a genome-wide association study (GWAS) of UL in up to 426,558 European women from FinnGen and a previous UL meta-GWAS. In addition to the 50 known UL loci, we identify 22 loci that have not been associated with UL in prior studies. UL-associated loci harbour genes enriched for development, growth, and cellular senescence. Of particular interest are the smooth muscle cell differentiation and proliferation-regulating genes functioning on t…

Hydraulic Habitat Structure Impacts Risk of Trematode Infection

2022

Abstract— Variability in infection rates of trematodes Diplostomum pseudospathaceum in 0+ rainbow trout Oncorhynchus mykiss under different hydraulic regimes was studied in the experimental setup with regulated flow rates and environmental heterogeneity. The average infection rate in the conditions of the current was 1.5 times less than that in the stagnant water. An increase of the flow rate from 3.2 to 11.3 cm/s did not result in lower infection rates, while the interindividual variability in the infection rate (coefficient of variation) tended to increase along with changing the still-water conditions (20%) to the high flow rate environments (40%) within the experiment. A decrease in th…

Experimental ecology on the interaction between the Puumala hantavirus and its host, the bank vole

2006

Eva Kallio tutki väitöskirjatyössään ihmisissä myyräkuumetta aiheuttavan, Hantaviruksiin kuuluvan Puumala-viruksen ja sen isäntälajin metsämyyrän välistä vuorovaikutussuhdetta. Tutkimuksessa selvisi viruksen säilyvän infektiokykyisenä pitkään isännän ulkopuolellakin ja voivan tarttua myyrästä toiseen tai myyrästä ihmiseen ilman suoraa kontaktia. Kallio osoitti myös ensimmäisen kerran hantaviruksen olevan haitallinen isäntälajilleen.Kallion osoittaman Puumala-viruksen ja metsämyyrän välisen vuorovaikutussuhteen piirteet voivat osaltaan vaikuttaa ihmisten myyräkuume-epidemioiden ilmentymiseen. Uuden tiedon avulla pystytään myös yhä luotettavammin mallintamaan ja ennustamaan epidemioiden esiin…

COVID-19 : uusi haaste myös urheilijoille

2020

COVID-19 on ollut toistaiseksi harvinainen sairaus nuorten urheilijoiden ikäryhmässä ja oireet ovat yleensä lievät. Se kannattaa kuitenkin diagnosoida, sillä tauti voi heikentää pitkään urheilijan suorituskykyä. COVID-19 -infektio voi myös levitä urheilutapahtumien yhteydessä. nonPeerReviewed

The effects of regular sauna bathing in conjunction with exercise on cardiovascular function : A multi-arm randomized controlled trial

2022

Regular exercise and sauna bathing have each been shown to improve cardiovascular function in clinical populations. However, experimental data on the cardiovascular adaptations to regular exercise in conjunction with sauna bathing in the general population is lacking. Therefore, we compared the effects of exercise and sauna bathing, to regular exercise using a multi-arm randomized controlled trial. Participants (n = 47) aged 49 ± 9 years with low physical activity levels, and at least one traditional CVD risk factor were randomly assigned (1:1:1) to guideline-based regular exercise and 15-minute post-exercise sauna (EXS), guideline-based regular exercise (EXE), or control (CON), for eight w…