Search results for "taudit"
showing 10 items of 347 documents
Association between ideal cardiovascular health and risk of sudden cardiac death and all-cause mortality among middle-aged men in Finland
2021
Background Strong associations have been demonstrated between the American Heart Association’s cardiovascular health (CVH) metrics and various cardiovascular outcomes, but the association with sudden cardiac death (SCD) is uncertain. We examined the associations between these CVH metrics and the risks of SCD and all-cause mortality among men in Finland. Methods and results We used the prospective population-based Kuopio Ischaemic Heart Disease cohort study, which consists of men between 42 and 60 years of age at baseline. CVH metrics were computed for 2577 men with CVH scores at baseline ranging from 0 to 7, categorized into CVH scores of 0–2 (poor), 3–4 (intermediate) and 5–7 (ideal). Mult…
Kestävyyskuntoa vai normaalipainoa sydäntautien ehkäisyyn?
2022
Sleep Duration and Risk of Fatal Coronary Heart Disease, Sudden Cardiac Death, Cancer Death, and All-Cause Mortality
2018
Background: Sleep duration has been shown to be associated with all-cause mortality, however its relationship with cause-specific fatal events remains uncertain. We examined the relationship between sleep duration and risk of fatal coronary heart disease (CHD), sudden cardiac death, cancer related death and all-cause mortality. Methods Sleep duration was self-reported at baseline examinations performed between March 20, 1984 and December 5, 1989 in 2,361 men aged 42-61 years old from the Kuopio Ischemic Heart Disease study. Of these 1734 (73.4%) men were free from CHD and cancer at baseline. Results: A total of 802 all cause deaths, 202 fatal coronary heart disease events, 141 sudden cardia…
Mortality by age, gene and gender in carriers of pathogenic mismatch repair gene variants receiving surveillance for early cancer diagnosis and treat…
2023
Background: The Prospective Lynch Syndrome Database (PLSD) collates information on carriers of pathogenic or likely pathogenic MMR variants (path_MMR) who are receiving medical follow-up, including colonoscopy surveillance, which aims to the achieve early diagnosis and treatment of cancers. Here we use the most recent PLSD cohort that is larger and has wider geographical representation than previous versions, allowing us to present mortality as an outcome, and median ages at cancer diagnoses for the first time.Methods: The PLSD is a prospective observational study without a control group that was designed in 2012 and updated up to October 2022. Data for 8500 carriers of path_MMR variants fr…
Efficient design and modeling strategies for follow-up studies with time-varying covariates
2015
Epidemiological studies can often be designed in several ways, some of which may be more optimal than others. Possible designs may differ in the required resources or the ability to provide reliable answers to the questions under study. In addition, once the data are collected, the selected modeling approach may affect how efficiently the data are utilized. The purpose of this dissertation is to investigate efficient designs and analysis meth ods in follow-up studies with longitudinal measurements. A key question is how to select optimally a subcohort for a new longitudinal covariate measurement if we cannot afford to measure the entire cohort. Another key question we consider is how to determine …
Underweight and obesity are related to higher mortality in patients undergoing coronary angiography: The KARDIO invasive cardiology register study
2022
Background: In patients with some cardiovascular disease conditions, slightly elevated body mass index (BMI) is associated with a lower mortality risk (termed “obesity paradox”). It is uncertain, however, if this obesity paradox exists in patients who have had invasive cardiology procedures. We evaluated the association between BMI and mortality in patients who underwent coronary angiography. Methods: We utilised the KARDIO registry, which comprised data on demographics, prevalent diseases, risk factors, coronary angiographies, and interventions on 42,636 patients. BMI was categorised based on WHO cut-offs or transformed using P-splines. Hazard ratios (HRs) with 95% confidence intervals (CI…
Menopausal Status and Physical Activity Are Independently Associated With Cardiovascular Risk Factors of Healthy Middle-Aged Women: Cross-Sectional a…
2019
Cardiovascular disease (CVD) is the primary cause of mortality in women in developed countries. CVD risk rises with age, yet for women there is a rapid increase in CVD risk that occurs after the onset of menopause. This observation suggests the presence of factors in the middle-aged women that accelerate the progression of CVD independent of chronological aging. Leisure time physical activity (LTPA) is a well-established protective factor against CVD. However, its role in attenuating atherogenic lipid profile changes and CVD risk in post-menopausal women has not been well-established. The present study is part of the Estrogenic Regulation of Muscle Apoptosis (ERMA) study, a population-based…
Impact of COVID-19 on Business Model Innovation at EdTech Startups
2021
Purpose: COVID-19 occurred at the end of 2019 and forced the world to change daily routines. Schools and offices were closed and needed to move to online mode. Educational technology (EdTech) aims to advance the learning results for students, foster individual approaches, and diminish teachers' burnout. The study aims to understand the impact of COVID-19 on business model innovation (BMI) at EdTech startups. Modern scholars show interest in researching firms that have various business models simultaneously. It is still unclear how business model diversification corresponds to its accomplishments. COVID-19 was a rapid and unexpected change. Hence, companies did not have much time to change t…
Lihasvoima- ja liikkuvuusmittaustulosten yhteys selkärankareuman taudin aktiivisuuteen
2003
Alkuperäinen aineisto julkaisulle: Differences in parasite community composition support ecological differentiation in a freshwater gadoid fish
2022
The data file contains original data from burbot (Lota lota), captured from two sampling depths, littoral and profundal, in Lake Konnevesi during the breeding season of the fish in 2019-2020. The other variables indicate total body length of the fish (mm), gender, and abundance of 9 metazoan parasite taxa observed in the fish. Column F indicates the mean coverage of cataracts caused by Diplostomum parasites found in the eye lenses (column E).