Search results for "taudit"
showing 10 items of 347 documents
Descriptive study on subjective experience of genetic testing with respect to relationship, family planning and psychosocial wellbeing among women wi…
2021
AbstractBackgroundDue to increased risk of endometrial and ovarian cancer, women belonging to known Lynch Syndrome (LS) families are recommended to undergo germline testing. Current practice in Finland is to offer counselling to women with pathogenic variant and advocate risk-reducing surgery (RRS) after completion of childbirth. The present study aimed to clarify the impacts of positive germline testing on family planning and reproductive decisions of these women, which are relatively unknown.MethodsSeventy-nine carriers of germline MMR gene pathogenic variant (path_MMR)were identified from the Finnish LS Registry as having genetic testing performed before the age of 45 years and not havin…
Bacteriophage Adherence to Mucus Mediates Preventive Protection against Pathogenic Bacteria
2019
The mucosal surfaces of animals are habitat for microbes, including viruses. Bacteriophages—viruses that infect bacteria—were shown to be able to bind to mucus. This may result in a symbiotic relationship in which phages find bacterial hosts to infect, protecting the mucus-producing animal from bacterial infections in the process. Here, we studied phage binding on mucus and the effect of mucin on phage-bacterium interactions. The significance of our research is in showing that phage adhesion to mucus results in preventive protection against bacterial infections, which will serve as basis for the development of prophylactic phage therapy approaches. Besides, we also reveal that exposure to m…
Effect of Omega-3 Dosage on Cardiovascular Outcomes : An Updated Meta-Analysis and Meta-Regression of Interventional Trials
2021
Objectives:To quantify the effect of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids oncardiovascular disease (CVD) prevention and the effect of dosage. Methods:This study is designed as a random effects meta-analysis and meta-regression of ran-domized control trials with EPA/DHA supplementation. This is an update and expanded analysis ofa previously published meta-analysis which covers all randomized control trials with EPA/DHAinterventions and cardiovascular outcomes published before August 2019. The outcomes includedare myocardial infarction (MI), coronary heart disease (CHD) events, CVDevents (a composite ofMI, angina, stroke, heart failure, peripheral arterial disease, sudden de…
Tertiary lymphoid structures in pulmonary metastases of microsatellite stable colorectal cancer
2023
Tertiary lymphoid structures (TLSs) are ectopic lymphoid aggregates located at sites of chronic inflammation and recognized as prognosticators in several cancers. We aimed to analyse the prognostic effect of TLSs in colorectal cancer (CRC) pulmonary metastases and primary tumours, with a comparison to the CD3+ and CD8+ cell density-based immune cell score (ICS). For TLS density and TLS maximum diameter analysis, 67 pulmonary metastases and 63 primary tumours were stained with haematoxylin and eosin. For ICS scoring and analysis, CD3 and CD8 immunohistochemistry was performed. Excellent interobserver agreement was achieved in all TLS measurements. Of all patients, 36 patients had low TLS den…
Biopsychosocial Profiles of Patients With Cardiac Disease in Remote Rehabilitation Processes : Mixed Methods Grounded Theory Approach
2021
Background: Digital development has caused rehabilitation services and rehabilitees to become increasingly interested in using technology as a part of rehabilitation. This study was based on a previously published study that categorized 4 groups of patients with cardiac disease based on different experiences and attitudes toward technology (e-usage groups): feeling outsider, being uninterested, reflecting benefit, and enthusiastic using. Objective: This study identifies differences in the biopsychosocial profiles of patients with cardiac disease in e-usage groups and deepen the understanding of these profiles in cardiac rehabilitation. Methods: Focus group interviews and measurements were c…
Kolesterolin esiintyminen ihmisen hermostollisissa syöpäsoluissa
2008
Innovatiiviset etäkuntoutuspalvelut
2019
Tutkimuksen tavoitteena oli tutkia ja kehittää etäteknologian käyttöä Kelan laitoskuntoutuksessa ja työhyvinvointipalveluna toteutetussa etäkuntoutuksessa. Kuntoutusryhminä olivat sydänkuntoutukseen osallistuneet, tuki- ja liikuntaelinsairauksia sairastavat ja ammatillisen työkyvyn tuen tarpeessa olevat asiakkaat. Ensimmäisenä tavoitteena oli arvioida eri kuntoutusmallien vaikuttavuutta asiakkaiden fyysiseen toimintakykyyn ja koettuun elämänlaatuun sekä etäteknologiaa hyödyntävän kuntoutuksen osallistumiseen. Toisena tavoitteen oli kartoittaa asiakkaiden ja henkilökunnan kokemuksia etäteknologiasta osana tavanomaista kuntoutusta ja etäkuntoutusta. Lisäksi tässä artikkelissa tarkastellaan tu…
Yksikammioisten sydänlasten motorinen kehitys 16 ja 52 viikon iässä, vertaileva tutkimus
2009
Tausta: Suomessa syntyy vuosittain noin 20 lasta, joilla on vaikea-asteisimpiin sydänvikoihin kuuluva yksikammioinen sydän, hypoplastinen vasemman kammion oireyhtymä (HLHS) tai muu yksikammioinen sydänvika (UVH). Aikaisemmin nämä lapset menehtyivät pian syntymän jälkeen. Suomessa on alettu hoitaa näitä lapsia vuodesta 1995 Norwoodin ym. 1980 kehittämän kolmivaiheisen leikkausmenetelmän avulla, jonka ansiosta suurin osa näistä lapsista jää henkiin. Näiden lasten kokonaiskehitys ja etenkin motorinen kehitys on osoittautunut olevan jäljessä verrattuna terveisiin lapsiin. Tutkimuksia, joissa yksikammioisten sydänlasten varhaista motorista kehitystä on tarkemmin kuvattu ja analysoitu ei ole löyt…
Exercise medicine for cancer cachexia: targeted exercise to counteract mechanisms and treatment side effects.
2022
Abstract Purpose Cancer-induced muscle wasting (i.e., cancer cachexia, CC) is a common and devastating syndrome that results in the death of more than 1 in 5 patients. Although primarily a result of elevated inflammation, there are multiple mechanisms that complement and amplify one another. Research on the use of exercise to manage CC is still limited, while exercise for CC management has been recently discouraged. Moreover, there is a lack of understanding that exercise is not a single medicine, but mode, type, dosage, and timing (exercise prescription) have distinct health outcomes. The purpose of this review was to examine the effects of these modes and subtypes to identify the most opt…