Search results for "taudit"

Menopausal symptoms and cardiometabolic risk factors in middle-aged women : A cross-sectional and longitudinal study with 4-year follow-up

2023

Objective To study associations of menopausal symptoms with cardiometabolic risk factors. Study design A cross-sectional and longitudinal study of a representative population sample of 1393 women aged 47–55 years with a sub-sample of 298 followed for four years. The numbers of vasomotor, psychological, somatic or pain, and urogenital menopausal symptoms were ascertained at baseline through self-report. Their associations with cardiometabolic risk factors were studied using linear regression and linear mixed-effect models. Models were adjusted for age, menopausal status, body mass index, the use of hormonal preparations, education, smoking, and alcohol consumption. Main outcome measures Card…

Hoitoaika lyhenee - koti kutsuu : lyhythoitoinen kirurginen toiminta vanhusten itsensä kokemana

2003

Lyhythoitoinen kirurginen toiminta on ulotettu enimmäkseen nuorille ja työikäisille. Iäkkäistä päiväkirurgisesti leikatuista potilaista suurin osa on kaihipotilaita, joiden palautteet päiväkirurgiasta ovat erinomaisen hyviä.Lyhythoitoinen kirurginen toiminta vaatii toimintaa myös potilaalta. Hänen on osattava lääkitä itseään selvitäkseen kivusta. Hänen on osattava hoitaa kotona itseään ja leikkausaluettaan niin, ettei se infektoidu. Leikkauksen jälkeenkin omasta kunnosta on huolehdittava ja pidettävä yllä sosiaalisia suhteita ja jatkettava harrastuksia. The aim of this study was to examine the experiences of elderly patients who have undergone day surgery of the care process. The aim was to…

Spore-forming parasites infecting muscles of freshwater fishes : ecology and epidemiology

2017

Fish parasites may potentially harm fisheries and aquaculture. Infected fish are unusable, even though they would not pose a direct risk to human health. The aim of this thesis was to investigate the ecology and epidemiology of three previously unknown or poorly known spore-forming parasites infecting muscles of economically important fish species. The first novel microsporidian species, here described as Microsporidium luciopercae, was found from pike-perch (Sander lucioperca) and European perch (Perca fluviatilis) and formed opaque-looking patches in the muscles. The second novel microsporidian species, Myosporidium spraguei, was found from pike-perch and burbot (Lota lota) and occurred w…

Testing for Lynch Syndrome in Endometrial Carcinoma: From Universal to Age-Selective MLH1 Methylation Analysis

2022

Simple Summary International guidelines recommend universal screening of endometrial carcinoma patients for Lynch syndrome, a hereditary cancer predisposition syndrome. Screening is based on mismatch repair protein immunohistochemistry and reflex MLH1 methylation analysis to exclude the likely sporadic cases of MMR deficiency. As sporadic MLH1 protein loss is common in endometrial carcinoma, the ability to target methylation testing would save efforts and costs. We discovered that limiting methylation testing to patients under 65 years would have significantly reduced the testing effort while maintaining a low false negative rate for MLH1-LS detection (0% and 3% in our clinic and registry-b…

Lynchin oireyhtymän syöpää ehkäisevä seuranta muuttuu geenikohtaiseksi

2020

Asetyylisalisyylihapon tehosta vakuuttavaa näyttöä ja rokote kehitteillä nonPeerReviewed

Is HLA type a possible cancer risk modifier in Lynch syndrome?

2022

Lynch syndrome (LS) is the most common inherited cancer syndrome. It is inherited via a monoallelic germline variant in one of the DNA mismatch repair (MMR) genes. LS carriers have a broad 30-80% risk of developing various malignancies, and more precise, individual risk estimations would be of high clinical value, allowing tailored cancer prevention and surveillance. Due to MMR deficiency, LS cancers are characterized by the accumulation of frameshift mutations leading to highly immunogenic frameshift peptides (FSPs). Thus, immune surveillance is proposed to inhibit the outgrowth of MMR-deficient cell clones. Recent studies have shown that immunoediting during the evolution of MMR-deficient…

Sports and exercise medicine clinic in public hospital settings: A real-life concept and experiences of the treatment of the first 1151 patients

2022

AbstractExercise has been shown to have a multitude of health-promoting effects, including improvements in cardiorespiratory and muscular fitness, function, symptoms and risk factors. Furthermore, exercise may slow down, stop or even reverse the progression of various non-communicable diseases (NCDs). Despite the overwhelming evidence, exercise is still not comprehensively used as a treatment component either in primary care or in hospital settings. The outpatient Sports and Exercise Medicine Clinic (SEMC) is the first specialized clinic in Finland to use exercise as part of patient protocols in the public health care system. Patients needing specialist attention due to NCDs, usually combin…

Antibacterial Efficiency of Surface-Immobilized Flavobacterium-Infecting Bacteriophage

2019

Control of bacterial diseases by bacteriophages (phages) is gaining more interest due to increasing antibiotic resistance. This has led to technologies to attach phages on surfaces to form a biomaterial that can functionally display phages that interact with bacteria, to carry out successful infection cycles. Such a material could be applied in many environments, where the target pathogens are expected. Although this approach has been applied successfully in a few studies already, the basis of the antibacterial effect by the immobilized phages is unclear, and the interpretation of the results depends on the study. Here, we studied the phage attachment density, their detachment rate and infe…

Exploring phage-bacterium interactions : new ways to combat a fish pathogen

2014

Kupan kehto. Prostituutio kansanterveydellisenä ongelmana 1800-luvun wieniläisten lääketieteilijöiden kirjoituksissa

2018

Järjestelmiä prostituution säätelemiseksi luotiin 1800-luvulla ympäri Eurooppaa. Wienissä prostituution säätely aloitettiin yli vuosikymmenen jatkuneiden debattien jälkeen vuonna 1873. Julkisen siveellisyyden suojelun ohella prostituoitujen rekisteröintiin ja säännöllisiin terveystarkastuksiin perustuneen säätelyjärjestelmän tavoitteena oli sukupuolitautien, erityisesti kupan, ennaltaehkäisy. Lääketieteilijöillä oli keskeinen rooli sekä säätelystä käydyssä julkisessa keskustelussa että sen käytännön toteutuksessa. Tämä artikkeli tutkii prostituutioon ympäri Eurooppaa kohdistunutta lääketieteellistä ongelmanmäärittelyä ja kontrollia tarkastelemalla wieniläislääkäreiden sekä wieniläisten lääk…