Search results for "taxi"
showing 10 items of 515 documents
Cognitive Deficits and Associated ERP N400 Abnormalities in FXTAS With Parkinsonism
2018
Objective: To examine cognitive deficits and associated brain activity in fragile X-associated tremor/ataxia syndrome (FXTAS) patients with parkinsonism (FXTp+), in relation to FXTAS patients without parkinsonism (FXTp-), and normal elderly controls (NC). Methods: Retrospective reviews were performed in 65 FXTAS patients who participated in the event-related brain potential (ERP) study and also had either a videotaped neurological examination or a neurological examination for extrapyramidal signs. Parkinsonism was defined as having bradykinesia with at least one of the following: rest tremor, postural instability, hypermyotonia, or rigidity. Eleven FXTp+ patients were identified and compare…
The ATXN1 and TRIM31 genes are related to intelligence in an ADHD background: evidence from a large collaborative study totaling 4,963 subjects
2010
Contains fulltext : 96400.pdf (Publisher’s version ) (Closed access) Intelligence is a highly heritable trait for which it has proven difficult to identify the actual genes. In the past decade, five whole-genome linkage scans have suggested genomic regions important to human intelligence; however, so far none of the responsible genes or variants in those regions have been identified. Apart from these regions, a handful of candidate genes have been identified, although most of these are in need of replication. The recent growth in publicly available data sets that contain both whole genome association data and a wealth of phenotypic data, serves as an excellent resource for fine mapping and …
Role of Adenosine Receptors in Rare Neurodegenerative Diseases with Motor Symptoms
2021
: The approval of istradefylline, an adenosine 2A receptor (A2AR) antagonist, as an addon treatment in adult patients with Parkinson’s disease by the Food and Drug Administration (FDA) and European Medicines Agency (EMA), is the latest proof of the importance of the adenosinergic system in the nervous system. Adenosine is an endogenous purine nucleoside with a role as a modulator of both neurotransmission and the inflammatory response. As such, the expression pattern of the 4 adenosine receptors (A1R, A2AR, A2BR and A3R) and the extracellular adenosine levels have attracted great interest in the pathogenesis and possible treatment of rare neurodegenerative diseases with motor symptoms. The…
Proposta d’ensenyament i aprenentatge de la construcció ho-transitiva catalana: una seqüència didàctica basada en la gramàtica de construccions
2021
L’ensenyament dels pronoms febles és un dels punts més complexos de l’ensenyament del català, sobretot com a segona llengua (L2). La tradició acadèmica ha relegat els pronoms febles a un context purament sintàctic que implica saber tot un seguit de conceptes que, si pensem en una L2, potser la major part d’alumnes no coneixen. És per això que aquest estudi presenta una seqüència didàctica basada en la gramàtica de construccions, i especialment en la Gramàtica de Construccions Aplicada (Gilquin i De Knop 2016), per a l’ensenyament i l’adquisició del que hem anomenat la construcció HO-TRANSITIVA. La gramàtica de construccions atorga un paper fonamental al significat de les formes gramaticals …
Dret administratiu II: La regulació dels taxi i dels VTC
2020
El document forma part dels materials docents programats mitjançant l'ajut del Servei de Política Lingüística de la Universitat de València. Diapositives de l'assignatura Dret administratiu II: La regulació dels taxi i dels VTC
Monitoring chemical and physical stress using sea urchin immune cells.
2005
Coelomocytes are the cells freely circulating in the body fluid contained in echinoderm coelom and constitute the defence system, which, in response to injuries, host invasion, and adverse conditions, is capable of chemotaxis, phagocytosis, and production of cytotoxic metabolites. Red and colourless amoebocytes, petaloid and philopodial phagocytes, and vibratile cells are the cell types that, in different proportions, constitute the mixed coelomocyte cell population found in sea urchins. Advances in cellular and molecular biology have made it possible to identify a number of specific proteins expressed in coelomocytes under resting conditions or when activated by experimentally induced stre…
La gramaticalització del futur i el condicional en català antic: el cas de les Vides de sants rosselloneses i els Furs de València
2021
El futur i el condicional de les llengües romàniques sorgeixen de la perífrasi llatina CANTĀRE HABEŌ mitjançant un procés de gramaticalització que passa per diferents estadis. En la llengua medieval, conviuen les formes sintètiques (el faré, faré-lo) i les formes analítiques (fer-lo he), que es distribueixen segons els diferents entorns sintàctics seguint la sintaxi medieval dels pronoms febles. En aquest estudi de corpus, s’extrauen mitjançant el CICA les dades de dues obres del segle XIII, un text religiós, les Vides de sants rosselloneses, i un text jurídic, els Furs de València, per tal de conèixer la sintaxi dels clítics medievals i d’observar el grau de gramaticalització que mostren l…
Papel de las Membranas Asociadas a Retículo Endoplasmático y Mitocondria (MAMs) en la fisiopatología celular de la Ataxia de Friedreich y su relevanc…
2022
Calcium (Ca2+) is involved in different cellular functions and signaling pathways, mediating between extracellular and intracellular signals. MAMs (Endoplasmic reticulum-mitochondria associated membranes) are specific close appositions formed by the physical interaction of the ER and the mitochondria, thus regulating the main intracellular Ca2+ flux by means of the communication between the two compartments. This is fundamental to maintain cell function and so it has been proposed as a common mechanism in neurodegeneration. Friedreich's Ataxia (FRDA) is an autosomal recessive neurodegenerative disorder in which patients show reduced levels of frataxin (FXN), a protein fundamentally associat…
Les adjectifs chez Daniel Pennac
1997
Impact of
2018
Drosophila melanogaster has been for over a century the model of choice of several neurobiologists to decipher the formation and development of the nervous system as well as to mirror the pathophysiological conditions of many human neurodegenerative diseases. The rare disease Friedreich’s ataxia (FRDA) is not an exception. Since the isolation of the responsible gene more than two decades ago, the analysis of the fly orthologue has proven to be an excellent avenue to understand the development and progression of the disease, to unravel pivotal mechanisms underpinning the pathology and to identify genes and molecules that might well be either disease biomarkers or promising targets for therap…