Search results for "tea"

La guerra del señor Bush y el 11-S

2002

Addressing Student Motivation, Self-regulation, and Engagement in Flipped Classroom to Decrease Boredom

2016

The interplay teacher regulation and student self- regulation of learning is an important topic in contemporary theories of teaching and learning. The pervasiveness of the boredom experienced by many students, along with its deleterious effects, clearly implies that educators, and teachers responsible for the design of academic settings should pay more attention to this emotion. With regard to the prevention or reduction of boredom, the present findings suggest that specific measures could focus on increasing the perceived values of activities in achievement settings. This study used mixed methodologies, including a student perception inventory and observations, to investigate whether teach…

Preclinical evaluation of antitumor activity of the proteasome inhibitor MLN2238 (ixazomib) in hepatocellular carcinoma cells

2017

AbstractHepatocellular carcinoma (HCC) is one of the common malignancies and is an increasingly important cause of cancer death worldwide. Surgery, chemotherapy, and radiation therapy extend the 5-year survival limit in HCC patients by only 6%. Therefore, there is a need to develop new therapeutic approaches for the treatment of this disease. The orally bioavailable proteasome inhibitor MLN2238 (ixazomib) has been demonstrated to have anticancer activity. In the present study, we investigated the preclinical therapeutic efficacy of MLN2238 in HCC cells through in vitro and in vivo models, and examined its molecular mechanisms of action. MLN2238 inhibited cell viability in human HCC cells He…

Development of peptidomimetic boronates as proteasome inhibitors.

2013

Abstract Proteasome inhibition has emerged over the past decade as an effective therapeutic approach for the treatment of hematologic malignancies. It is a multicatalytic complex, whose proteolytic activity relies in three types of subunits: chymotrypsin-like (β5), trypsin-like (β2) and caspase-like (β1). Most important for the development of effective antitumor agents is the inhibition of the β5 subunits. In this context, the dipeptide boronate bortezomib (Velcade ® ) represents the first proteasome inhibitor approved by the FDA and the lead compound in drug discovery. This paper describes the synthesis and biological evaluation of a series of conformationally constrained pseudopeptide bor…

Unsteady Separation and Navier-Stokes Solutions at High Reynolds Numbers

2010

We compute the numerical solutions for Navier-Stokes and Prandtl’s equations in the case of a uniform bidimensional flow past an impulsively started disk. The numerical approx- imation is based on a spectral methods imple- mented in a Grid environment. We investigate the relationship between the phenomena of unsteady separation of the flow and the exponential decay of the Fourier spectrum of the solutions. We show that Prandtl’s solution develops a separation singularity in a finite time. Navier-Stokes solutions are computed over a range of Reynolds numbers from 3000 to 50000. We show that the appearance of large gradients of the pressure in the stream- wise direction, reveals that the visc…

Affidabilità del bright liver nella diagnosi di steatosi epatica in pazienti con infezione da virus dell'immunodeficienza acquisita (HIV), da virus d…

2009

Stones, Bones, and Hillfort: Radiocarbon Dating of Ķivutkalns Bronze-Working Center

2013

The Bronze Age site of ķivutkalns with its massive amount of archaeological artifacts and human remains is considered the largest bronze-working center in Latvia. The site is a unique combination of cemetery and hillfort believed to be built on top of each other. This work presents new radiocarbon dates on human and animal bone collagen that somewhat challenge this interpretation. Based on analyses using a Bayesian modeling framework, the present data suggest overlapping calendar year distributions for the contexts within the 1st millennium BC. The carbon and nitrogen isotopic ratios indicate mainly terrestrial dietary habits of studied individuals and nuclear family remains buried in one o…

Marfil para los muertos en la Cultura de las Motillas: los botones de Castillejo del Bonete (Terrinches, Ciudad Real).

2015

Madrider Mitteilungen, 56 (2015)

Les modes d'habitat à l'âge du Bronze en France

2018

The many discoveries made in preventive archaeology have drawn the picture of a highly anthropogenic landscape in Bronze Age France. Timber post buildings are the most common type of dwellings however other types of construction (sills, mudbrick, …) that have lighter foundations and are more susceptible to erosion are considered less common due to the inherent problems of identification. Small dwellings from 25 to 40 m2 with a quadrangular 1 to 3 aisled plan and built to house a nuclear family are the most common,. Other types of buildings differ from this standardised plan such as the long rectangular dwellings in Alsace dating to the Early Bronze Age (type Eching) or the Early Bronze Age …

Closure of oroantral communications with Bichat´s buccal fat pad. Level of patient satisfaction

2015

Purpose: To report the closure of oroantral communications with the pedicled buccal fat pad in a series of patients, and to determine the level of patient satisfaction after the surgery. Study Design: A prospective study of patients diagnosed of unilateral or bilateral oroantral communication (OAC) closed using the buccal fat pad between May 2012 and January 2013 was performed. Data analysis extended to: age, sex, and cause, location and size of oroantral communication. Complications and success related to buccal fat pad surgery were evaluated. Also, patient satisfaction was assessed after six months of surgery. Results: Nine patients (3 men and 6 women) with a mean age of 50.5 years and 11…