Search results for "tecniche"

Clinical and biochemical determinants of the extent of liver steatosis in type 2 diabetes mellitus

2015

Objective Nonalcoholic fatty liver disease is very frequent in both type 2 diabetes mellitus (T2DM) and the metabolic syndrome (MS), which share clinical and metabolic characteristics. Whether and to which extent these characteristics can predict the degree of liver steatosis are not entirely clear. Patients and methods We determined liver fat (divided into four classes) by standard sonographic images, and clinical and biochemical variables, in 60 consecutive patients with T2DM and with features of the MS. We examined both simple and multiple correlations between the degree of liver steatosis and the variables measured. Results Increased liver fat (defined as >5% of liver mass) was detec…

Yeast Chronological Lifespan: Longevity Regulatory Genes and Mechanisms

2022

S. cerevisiae plays a pivotal role as a model system in understanding the biochemistry and molecular biology of mammals including humans. A considerable portion of our knowledge on the genes and pathways involved in cellular growth, resistance to toxic agents, and death has in fact been generated using this model organism. The yeast chronological lifespan (CLS) is a paradigm to study age-dependent damage and longevity. In combination with powerful genetic screening and high throughput technologies, the CLS has allowed the identification of longevity genes and pathways but has also introduced a unicellular “test tube” model system to identify and study macromolecular and cellular damage lead…

The Mediterranean diet and its individual components: Linking with obesity in Italy

2020

Abstract A prolonged positive energy balance may contribute to fat accumulation and obesity development. It was observed several years ago that population resident in southern Italy consumed a particular diet and was less obese and lived significantly longer, and it was referred as the Mediterranean diet. The Mediterranean diet is a dietary plan based on fruits, vegetables, olive oil, and low intake of saturated fatty acids. A large body of literature suggested that the Mediterranean diet is effective in preventing obesity. Both observational and intervention studies clearly demonstrated that a higher adherence to Mediterranean diet is associated with a reduced risk of being obese and that …

Mediterranean diet and cancer: epidemiological evidence and mechanism of selected aspects

2013

Background: Populations living in the area of the Mediterranean Sea suffered by decreased incidence of cancer compared with those living in the regions of northern Europe and US countries, attributed to healthier dietary habits. Nowadays, we are assisting to a moving away from the traditional Mediterranean dietary pattern, but whether this changing is influencing risk of cancers is still unclear. The aim of the study was to review recent evidence on potential relationship between the adherence to the Mediterranean diet and cancer. Discussion: The most recent pooled analyses of epidemiological studies supported strongly the hypothesis that the Mediterranean diet may play a role in preventing…

DeepSRE: Identification of sterol responsive elements and nuclear transcription factors Y proximity in human DNA by Convolutional Neural Network anal…

2021

SREBP1 and 2, are cholesterol sensors able to modulate cholesterol-related gene expression responses. SREBPs binding sites are characterized by the presence of multiple target sequences as SRE, NFY and SP1, that can be arranged differently in different genes, so that it is not easy to identify the binding site on the basis of direct DNA sequence analysis. This paper presents a complete workflow based on a one-dimensional Convolutional Neural Network (CNN) model able to detect putative SREBPs binding sites irrespective of target elements arrangements. The strategy is based on the recognition of SRE linked (less than 250 bp) to NFY sequences according to chromosomal localization derived from …

Misure di permeabilità al vapore: Sistema automatico per acquisizione dati, mediante LabView®, con pesata diretta, continua e contemporanea su tre ca…

2002

Atti del convegno: X Incontro Annuale dei Giovani Ingegneri Geotecnici

2021

Questo volume raccoglie gli atti della decima edizione dell’Incontro Annuale dei Giovani Ingegneri Geotecnici, tenutosi a Pisa il 3 e 4 settembre 2021. IAGIG è un’iniziativa dell'Associazione Geotecnica Italiana (AGI) che vuole promuovere tra i suoi Giovani Soci la discussione di argomenti di Ingegneria Geotecnica con riferimento alla pratica professionale ed alle innovazioni proposte dalla ricerca. L'iniziativa è stata pensata, quindi, per coinvolgere liberi professionisti, dipendenti di enti pubblici o di imprese, giovani imprenditori del settore, neo-laureati, giovani ricercatori. Il volume raccoglie 60 contributi, divisi in quattro sessioni: modellazione numerica e fisica dei terreni e …

Bioavailability in vivo of naltrexone following transbuccal administration by an electronically-controlled intraoral device: a trial on pigs.

2010

Naltrexone (NLX), an opioid antagonist, is widely used in the treatment of opiate addiction, alcoholism and smoking cessation. Its current peroral administration induces various adverse side effects and has limited efficacy since bioavailability and patient compliance are poor. The development of a long-acting drug delivery system of NLX may overcome the current drawbacks and help in the improvement of treatment of addiction. The primary endpoints of this study were: a) to compare the NLX bioavailability and pharmacokinetics after delivering a single transbuccal dose, released by a prototype of intraoral device, versus an intravenous (I.V.) bolus of the same drug dose; b) to verify the func…

TAKING INSPIRATION FROM NATURE: RULES AND PROCEDURES FOR A GOOD BUILDING PRACTICE

2016

Sin dai tempi antichi si sono sfruttati gli alberi ed altri elementi vegetali per scopi costruttivi: la natura, in generale, è stata di ispirazione e ha insegnato una serie di regole, a lungo imitate ed applicate. Alcune delle numerose specie arboree hanno rappresentato, infatti, degli esempi per le costruzioni primitive e, successivamente, per gli stili architettonici classici: possiamo annoverare i primi rifugi estemporanei ed ispirati a criteri di urgenza e praticità, o anche ben più ragionati edifici, fatti di elementi vegetali assemblati fra di loro. Questi manufatti architettonici richiamavano la natura nel suo fiorente sviluppo e nel sapiente e preciso equilibrio. L’architettura clas…

Taking inspiration from nature: rules and procedures for a good building practice

2016

Sin dai tempi antichi si sono sfruttati gli alberi ed altri elementi vegetali per scopi costruttivi: la natura, in generale, è stata di ispirazione e ha insegnato una serie di regole, a lungo imitate ed applicate. Alcune delle numerose specie arboree hanno rappresentato, infatti, degli esempi per le costruzioni primitive e, successivamente, per gli stili architettonici classici: possiamo annoverare i primi rifugi estemporanei ed ispirati a criteri di urgenza e praticità, o anche ben più ragionati edifici, fatti di elementi vegetali assemblati fra di loro. Questi manufatti architettonici richiamavano la natura nel suo fiorente sviluppo e nel sapiente e preciso equilibrio. L’architettura clas…