Search results for "temi"
showing 10 items of 3194 documents
Stress Hyperglycemia as Predictive Factor of Recurrence in Children with Febrile Seizures
2020
Stress hyperglycemia and hyperlactatemia are commonly referred to as markers of stress severity and poor outcome in children with severe acute illness or febrile seizures. Our prospective study aimed to explore the risk factors for stress hyperglycemia and the predictive value of stress hyperglycemia for febrile seizure recurrence. We evaluated as risk factors for blood glucose level, serum lactate, acid&ndash
Interaction Between Cytokines and Oxidative Stress in Acute Pancreatitis
2006
Acute pancreatitis is an inflammation initially localized in the pancreatic gland which may lead to local and systemic complications. The development of severe acute pancreatitis is mediated by pathophysiological mechanisms involved in the systemic inflammatory response, cytokines and oxidative stress being their components of major importance. Nevertheless, it is still unknown why an episode of acute pancreatitis remains mild or progresses to a severe form. Activated leukocytes are the main source of cytokines. Interleukin 1beta and tumor necrosis factor alpha (TNF-alpha) initiate and propagate almost all the consequences of the systemic inflammatory response syndrome, leading to amplifica…
Interferon-beta: a therapeutic for autoimmune lupus in MRL-Faslpr mice.
2005
Type I interferons are associated with lupus. Genes that are regulated by IFN-alpha are upregulated in pediatric lupus patients. Gene deletion of the IFN-alpha/beta receptor in experimental lupus-like NZB mice results in reduced disease activity. Conversely, IFN-beta is a well-established treatment in multiple sclerosis, another autoimmune disease. For determining whether IFN-beta treatment is harmful or beneficial in lupus, MRL-Fas(lpr) mice were injected with this type I IFN. Treatment was initiated in MRL-Fas(lpr) mice with mild and advanced disease. IFN-beta was highly effective in prolonging survival and ameliorating the clinical (renal function, proteinuria, splenomegaly, and skin les…
Cytotoxicity of natural products and derivatives toward MCF-7 cell monolayers and cancer stem-like mammospheres
2015
Abstract Although cancer stem-like cells (CSCs) are rare, they can enter a non-proliferative or dormant state and resist therapy. Furthermore, quiescent CSCs are responsible for metastases that can appear after curative surgical treatment of a primary tumor. Because of drug resistance of CSCs, the development of novel therapies is urgently required that specifically target CSCs. Purpose The aim of the present study was to investigate the potential of a panel of natural products and derivatives to inhibit CSC-enriched mammospheres of MCF-7 breast cancer cells. Methods CD44high/CD24low cells were identified by flow cytometry and maintained as mammospheres. As a control, we used two clinically…
A Cost-Effective Solution for Clearing High-Impedance Ground Faults in Overhead Low-Voltage Lines
2019
Downed distribution conductors in overhead distribution systems may not be a concern for equipment but greatly challenge the safety of persons, as well as the integrity of properties. Standard overcurrent protective devices may not be able to detect the magnitudes of currents resulting from high-impedance ground faults. Sophisticated relays able to detect high-impedance ground faults have been available to electric utilities. However, their implementation is rather uncommon, especially in developing countries, most likely due to their costs. In this paper, the authors formalize the problem, and propose a possible cost-effective solution for low-voltage overhead lines with neutral wire. This…
Dalle mafie tradizionali ai sistemi criminali. E’ tutta questione di metodo
2008
Sistemi criminali e metodo mafioso (numero monografico di "Questione Giustizia")
2008
Il numero raccoglie le riflessioni e i contributi maturati durante il seminario di studi dal titolo Il metodo mafioso: dalle mafie tradizionali ai sistemi criminali svoltosi a Palermo tra il 19 ottobre e il 14 dicembre 2007.Il seminario – organizzato sotto il patrocinio della Facoltà di Scienze della Formazione dell’Università degli Studi di Palermo, in collaborazione con l’Ufficio dei Referenti per la Formazione professionale del Distretto di Palermo del Consiglio Superiore della Magistratura – ha rappresentato un’importante occasione per riunire a confronto operatori del diritto e studiosi del fenomeno mafioso, e con loro dar vita a una serie di momenti di riflessione e di scambio di cono…
IL PAGAMENTO “NECESSARIAMENTE INTERMEDIATO” DELL’OBBLIGAZIONE PECUNIARIA NELLA LEGISLAZIONE DI DERIVAZIONE EUROPEA: VERSO IL SUPERAMENTO DELL’UNICITÀ…
2015
Il lavoro muove dall’idea di analizzare il sistema delle regole che definiscono, sul piano dell’an, del quando e del quomodo, l’esattezza dell’adempimento che può definirsi (necessariamente) intermediato dell’obbligazione pecuniaria: nella vicenda solutoria della quale, cioè, risulti indefettibile, per volontà della legge o per scelta dei privati, l’interposizione di uno o più soggetti, altri rispetto al debitore e al creditore parti originarie del rapporto obbligatorio, con funzioni ausiliarie. Ciò al fine di saggiare la bontà della ipotesi ricostruttiva in base alla quale l’adempimento dell’obbligazione pecuniaria per mezzo di operazioni di pagamento intermediato non sia governato dalla l…
Assessment of the production costs curve in micro-grids: a comparative analysis
2012
In micro-grids, due to their small scale, there is commonly only one power supplier. A competitive wholesale market hardly exists so the question about how to consider market issues for small producers within micro-grids arises. On the other hand, the specific features of micro-grids where load and generated power hardly find a balance, require that customers take part to regulation issues, maybe using demand response programs. In this paper, price responsive policies and its programs are discussed to answer this question. A case study of a micro-grid with one microturbine and two photovoltaic generators in Italy is analyzed to assess the overall production cost in order to build a price re…
Epistemic uses of the pretérito pluscuamperfecto in La Paz Spanish
2020
This paper explores epistemic-evidential uses of the pluperfect, i.e. pretérito pluscuamperfecto, in La Paz Spanish. The pretérito pluscuamperfecto displays functions of a reported evidential form, conforming to results from previous studies on Argentinian Spanish (Bermúdez 2008; Speranza 2014) and, furthermore, is used according to a previously unnoticed inferential evidential function. Using theoretical frameworks from Kockelman (1957) and Bergqvist (2018), this paper describes the configuration of participant roles and event types implied in the different evidential functions of the pretérito pluscuamperfecto.