Search results for "temi"

showing 10 items of 3194 documents

The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress.

2021

Summary: Chromatin organization plays a crucial role in tissue homeostasis. Heterochromatin relaxation and consequent unscheduled mobilization of transposable elements (TEs) are emerging as key contributors of aging and aging-related pathologies, including Alzheimer’s disease (AD) and cancer. However, the mechanisms governing heterochromatin maintenance or its relaxation in pathological conditions remain poorly understood. Here we show that PIN1, the only phosphorylation-specific cis/trans prolyl isomerase, whose loss is associated with premature aging and AD, is essential to preserve heterochromatin. We demonstrate that this PIN1 function is conserved from Drosophila to humans and prevents…

transposonsNeocortexMiceHeterochromatinProlyl isomeraseDrosophila ProteinsBiology (General)PhosphorylationRNA Small InterferingTissue homeostasisCells CulturedSettore ING-INF/05 - Sistemi Di Elaborazione Delle InformazioniNeuronsLamin Type BChemistryHP1phosphorylationneurodegenerationnuclear envelopePeptidylprolyl IsomeraseCell biologyDrosophila heterochromatin HP1 Lamin mechanical stress neurodegeneration nuclear envelope phosphorylation PIN1 transposonsNuclear laminaDrosophilaRNA InterferencePremature agingQH301-705.5HeterochromatinNuclear EnvelopeDrosophila; heterochromatin; HP1; Lamin; mechanical stress; neurodegeneration; nuclear envelope; phosphorylation; PIN1; transposonsSettore BIO/11 - Biologia MolecolareSettore MED/08 - Anatomia PatologicaGeneral Biochemistry Genetics and Molecular BiologyPIN1Alzheimer DiseaseSettore MED/05 - Patologia ClinicaAnimalsHumansHeterochromatin maintenancemechanical stressheterochromatinmechanical streMice Inbred C57BLNIMA-Interacting Peptidylprolyl IsomeraseChromobox Protein Homolog 5DNA Transposable ElementsHeterochromatin protein 1Stress MechanicalLaminLaminCell reports
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Turismo relazionale in tre sistemi territoriali

2007

L'azione di ricerca ha lo scopo di verificare la presenza, nei tre contesti di studio (Val d’Anapo, Valle dell’Halaesa, S. Vito) di un’ offerta turistica che dispone di un sistema di relazioni formali ed informali al fine di ottenere un'idonea “mappatura” dei tre territori per determinare, con rigore scientifico, il fabbisogno turistico in chiave relazionale. Un secondo aspetto riguarda la verifica della dimensione relazionale con riferimento alla domanda turistica effettiva e potenziale delle località. Si vuol stabilire quali e quanti sono le relazioni presenti tra domanda turistica e sistema dell’offerta, sia attuali che potenziali ed in che termini questi contatti siano in grado di influ…

turismo relazionale sistemi turistici locali network relazionaliSettore SECS-P/06 - Economia Applicata
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Digital ulcer, Raynaud phenomenon and osteomyelitis of the fifth finger in patient with systemic sclerosis: personal experience

2012

ulcer raynaud phenomenon osteomyelitis scleroderma systemic
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La nuova tutela penale europea dei sistemi di informazione. Una prima lettura della nuova direttiva 2013/40/UE del Parlamento europeo e del Consiglio

2013

unione europeadiritto penalesistemi informaticiSettore IUS/17 - Diritto Penale
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Real-world experience with obeticholic acid in patients with primary biliary cholangitis

2021

Background & aims Obeticholic acid (OCA) is the second-line treatment approved for patients with primary biliary cholangitis (PBC) and an inadequate response or intolerance to ursodeoxycholic acid. We aimed to evaluate the effectiveness and safety of OCA under real-world conditions. Methods Patients were recruited into the Italian PBC Registry, a multicentre, observational cohort study that monitors patients with PBC at national level. The primary endpoint was the biochemical response according to Poise criteria; the secondary endpoint was the biochemical response according to normal range criteria, defined as normal levels of bilirubin, alkaline phosphatase (ALP), and alanine aminotransfer…

upper limit of normalCirrhosisALTAMAAutoimmunityantinuclear antibodiesULNPBCGastroenterologyUDCASettore MED/12ULN upper limit of normalobeticholic acidaRR adjusted risk ratio.CRFs case record formAST aspartate transferaseClinical endpointGGT gamma-glutamyl transferaseQCprimary biliary cholangitisGastroenterologyUrsodeoxycholic acidANATCCCirrhosisCholestasiTIPSTreatment Completer CohortANA antinuclear antibodiemedicine.medical_specialtyRRUDCA ursodeoxycholic acidTIPS transjugular intrahepatic portosystemic shuntOCACirrhosiALP alkaline phosphataseautoimmune hepatitismedicine.diseasedigestive system diseasesDiscontinuationKeywords: AIH autoimmune hepatitiQC quality controlchemistrygamma-glutamyl transferaserandomised controlled trialelectronic data captureantimitochondrial antibodiesaspartate transferaseAutoimmune hepatitischemistry.chemical_compoundAIHCRFsImmunology and Allergyadjusted risk ratioANA antinuclear antibodiesRR risk ratioOverall cohortALT alanine transferaseAMA antimitochondrial antibodieCholestasisCRFs case record formsObeticholic acidOverlap PBC-AIHursodeoxycholic acidOCA obeticholic acidTolerabilityalkaline phosphataseRCTResearch Articlemedicine.drugcase record formsContext (language use)AMA antimitochondrial antibodiesInternal medicineEDC electronic data capturetransjugular intrahepatic portosystemic shuntInternal MedicinemedicineRCT randomised controlled trialaRR adjusted risk ratioOClcsh:RC799-869quality controlalanine transferaseASTaRRHepatologybusiness.industryAutoimmunity; Cholestasis; Cirrhosis; Overlap PBC-AIHAIH autoimmune hepatitisTCC Treatment Completer CohortPBC primary biliary cholangitiGGTrisk ratioOC Overall cohortALPlcsh:Diseases of the digestive system. GastroenterologyPBC primary biliary cholangitisbusinessEDC
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Urban Landscapes and Resilience. Exploring an adaptive design perspective

2017

Il concetto di resilienza in pianificazione è emerso in tempi recenti come un mezzo potente per sostenere la ricerca e l'innovazione sua nella teoria che nella pratica. Partendo da una definizione delle città come sistemi adattivi complessi, organismi viventi in un contesto di non-equilibrio e spazi di intensa interazione e interdipendenza uomo-natura, il contributo intende esplorare il ruolo dei servizi ecosistemici nella costruzione della resilienza urbana. Il cambiamento globale e l'incertezza richiedono un approccio strategico verso la resilienza urbana, attraverso l'adaptive design. Mentre una visione basata sullo stato di equilibrio tende a guardare alla forma urbana ideale, riconosce…

urban resilience ecosystem services adaptive designSettore ICAR/21 - Urbanisticaresilienza urbana sistemi adattivi complessi città pianificazione servizi ecosistemici
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Urheiluakatemiat osana suomalaista huippu-urheilujärjestelmää : urheilun ja opiskelun yhdistäminen korkea-asteella

2008

urheiluopiskelukorkea-asteen koulutusuranvalintavalmennuskoulutuspalveluthuippu-urheiluurheiluakatemiaturheilijat
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Turun Akatemian väitöskirjojen latinan- ja kreikankielisestä urheiluterminologiasta 1697-1813

1997

Esittelen kolme Turun Akatemiassa ilmestynyttä urheiluaiheista väitöskirjaa, joista olen poiminut latinalaisen ja kreikkalaisen urheilu-terminologian ja esitellyt ne taulukoiden muodossa: I urheilusta käytetyt nimitykset, II-III urheilulajeista käytetyt nimitykset, IV-V urheilijoiden nimitykset; VI urheilusuoritukset, VII urheiluvälineet ja suorituspaikat. Edelleen tarkastelen termien merkitystä ja kääntämistä, joka ei aina ole ongelmatonta; esim. 'hiihto' (s. 46), josta käytetään mm. termejä cursus/ludus/ usus xylosolearum sekä super nives currendi methodus. Työn lopussa on ko. väitöskirjoista koottu latinalais-suomalainen ja suomalais-latinalainen urheilusanasto, sekä erillinen kreikankie…

urheiluterminologiaKuninkaallinen Turun akatemia
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Olof Schalberg : akateeminen perintö ja teoreettisen filosofian rappiotila

2022

virantäyttöTurun akatemiahyödyn aikakausioppihistoriaprofessoritSchalberg Olaus 1733-1804valistuksen aikatiedepolitiikkateoreettinen filosofiakulttuurihistoriayliopistot1700-luku
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Damping Provision by Different Virtual Synchronous Machine Schemes

2020

The adoption of virtual synchronous machine (VSM) schemes for the control of power converters is gaining more and more attention both in academia and industry. The VSM control strategies fall into the category of grid-forming converter controls, and they are intended for a range of different applications, providing specific services and different kinds of support to the grid. The paper investigates the possibility of damping provision to the system by VSM power converters. Different schemes are considered and compared, showing the opportunity of the investigated solutions through combined modal and time domain analyses. A specific modification of the power synchronization loop is recognized…

virtual synchronous machineComputer science020209 energy020208 electrical & electronic engineeringControl engineering02 engineering and technologysystem oscillationsConvertersdynamic analysisGridDampingSynchronizationgrid formingPower (physics)Phase-locked loopSettore ING-IND/33 - Sistemi Elettrici Per L'EnergiaModal0202 electrical engineering electronic engineering information engineeringTime domainSynchronous motor
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