Search results for "temi"
showing 10 items of 3194 documents
A Web based remote control of CNC machines
2009
Due to the large variety of products in small batch sizes, a modern machining shop floor requires an advanced real-time control system able to both monitor all the features and adapt the manufacturing system to the rapid changes of production capability and functionality. This is especially true when the shop floors are combined with the e-Manufacturing concept. e-Manufacturing is a transformation system which enables the manufacturing operations to achieve a predictive near-zero-downtime performance as well as to synchronize with the management systems through the use of infotronics technologies (i.e., wireless connections, web applications, networking systems, etc.). In recent years, the …
Low‐cost, High‐Capability, Embedded Systems for CNC Education and Research
2015
Teaching of CNC and CAD/CAM technologies has recently taken a great importance, due to their development, to the great number of solutions available on the market, and to the frequent updates. Nevertheless, one of the most urgent need is to improve the quality of education coping with a rapidly growing number of students. Nowadays, in comparison to the past, many Open-Source technical solutions, both hardware and software, are available to realise easily and cheaply some scaled-down prototypes of numerical control machine tools: these are able to work perfectly and can be employed as a learning method. This paper shows some past experiences regarding the development of some degree thesis wo…
Influence of Material-Related Aspectsof Additive and Subtractive Ti-6Al-4VManufacturing on Energy Demandand Carbon Dioxide Emissions
2017
The additive manufacturing of metal parts represents a promising process that could beused alongside traditional manufacturing methods. The research scenario in this field isstill largely unexplored, as far as the technological solutions adopted to integrate differentprocesses are concerned and in terms of environmental and economic impact assessment.In this article, an electron beam melting (EBM) process and a machining process have beenanalyzed and compared using a cradle-to-grave life cycle–based approach. The productionof components made of the Ti-6Al-4V alloy has been assumed as a case study. Theproposed methodology is able to account for all of the main factors of influence on energydem…
COVID-19 Vaccination in Pediatric Population: A Necessity or Obstruction to the Protection of the Right to Health? Biojuridical Perspective.
2022
One of the most recently debated topics worldwide is the mass vaccination of children against coronavirus disease 2019 (COVID-19). Next, the risk/benefit ratio of COVID-19 vaccination and infection in children are compared. Nonetheless, the real question in this debate is as follows: Does the vaccine represent a necessary tool or is it an obstacle in protecting the right to health? From a public health point of view, the Supreme Court of Nova Scotia, in Canada, recommends COVID-19 vaccination in the pediatric population. Based on Article 25 of the Draft Articles on State responsibility, vaccination can be considered a social act necessary for protecting the individual's right to health. The…
Pulmonary functional and radiological correlations of nutritional status and physical activity in systemic sclerosis
2011
Purpose Methods and Materials Results Conclusion References Personal Information
The flesh ethanolic extract of Hylocereus polyrhizus exerts anti-inflammatory effects and prevents murine colitis
2015
IBD is a chronic disorder of the gastrointestinal tract characterized by mucosal inflammation and epithelial damage. Biologic therapy has significantly improved the course of the disease but there are still a high percentage of patients that do not respond to current therapies. We aim to determine the effects of the flesh ethanolic extract of Hylocereus polyrhizus (EH) in a mice model of colitis induced by TNBS.Balb/c mice received TNBS (175 mg/kg, 100 μl, i.r.) and six and thirty hours later were administered with EH (1 g/kg, i.p.). Mice were weighted daily and after sacrificing (2 and 4 days after TNBS) we analyzed mucosal histology, myeloperoxidase activity (MPO), the expression of pro-i…
Comparing the acute response to cadmium toxicity of nauplii from different populations ofArtemia
2002
The lethal responses to cadmium of instar II nauplii from eight populations of Artemia belonging to the species Artemia franciscana, Artemia salina, Artemia persimilis, and Artemia parthenogenetica have been compared. Generalized linear models were used to fit mortality. The model indicates that there is a relationship between species, type of population, and mortality rate. The two populations of A. franciscana were the most sensitive to cadmium toxicity (median lethal concentration, LC50, of 93.3-142 mg/L), while the population of A. persimilis was the most resistant (LC50 of 284 mg/L). Differences in the phenotypic variability in each population were assessed through the slope of the mor…
Low preoperative cholesterol level is a risk factor of sepsis and poor clinical outcome in patients undergoing cardiac surgery with cardiopulmonary b…
2014
Systemic inflammatory response syndrome and sepsis frequently occur after cardiac surgery with cardiopulmonary bypass. The aim of the present study was to investigate whether preoperative cholesterol levels can predict sepsis onset and postoperative complications in patients undergoing cardiac surgery with cardiopulmonary bypass.Prospective observational study.Surgical ICU of a French university hospital.Two hundred and seventeen consecutive patients older than 18 years admitted for planned cardiac surgery with cardiopulmonary bypass.Measurements of plasma blood lipids and inflammation markers before anesthesia induction (baseline), at cardiopulmonary bypass start, at cardiopulmonary bypass…
Abstract 1993: Fishing for artemisinin-interacting proteins from human nasopharyngeal cancer cells
2012
Abstract Determining cellular target molecules of drugs by chemical proteomic techniques is complex and tedious. Most approaches rely on activity-based probe profiling and compound-centric chemical proteomics. The antimalarial artemisinin also exerts profound anti-cancer activity, but the mechanisms of action are incompletely understood. In the present study, we have identified artemisinin-interacting target proteins from human nasopharyngeal carcinoma cell line CNE1. Thereby, our approach overcomes usual problems in traditional fishing procedures, because the drug was attached to a polystyrene surface without further chemical modification. Using mass spectrometry we have identified 20 prot…
Artesunate derived from traditional Chinese medicine induces DNA damage and repair.
2008
Abstract Artesunate is a semisynthetic derivative from artemisinin, a natural product from the Chinese herb Artemisia annua L. It exerts antimalarial activity, and, additionally, artemisinin and its derivatives are active against cancer cells. The active moiety is an endoperoxide bridge. Its cleavage leads to the formation of reactive oxygen species and carbon-centered radicals. These highly reactive molecules target several proteins in Plasmodia, which is thought to result in killing of the microorganism. DNA damage induced by artemisinins has not yet been described. Here, we show that artesunate induces apoptosis and necrosis. It also induces DNA breakage in a dose-dependent manner as sho…