Search results for "temi"

¿La "reina de la fiesta"? Fiestas tradicionales y reproducción de la desigualdad de género. El caso de las Fallas de València

2020

Las desigualdades de género en las fiestas tradicionales han generado una creciente atención social y académica. Fenómenos como el acoso, abuso o agresiones sexuales, los roles segregados o las codificaciones patriarcales que facilitan instituciones festivas muy masculinizadas, tanto en las composiciones como en las dinámicas internas, han revelado que existe una persistencia en el mantenimiento que choca con la evolución de la sociedad hacia una mayor igualdad. En este sentido entendemos que la cultura festiva tradicional no puede interpretarse correctamente desde la dimensión del consenso sino como una arena de conflicto social. En esta perspectiva la idea del ritual festivo como generado…

A Hybrid Recommender System for Cultural Heritage Promotion

2021

Assisting users during their cultural trips is paramount in promoting the heritage of a territory. Recommender Systems offer the automatic tools to guide users in their decision process, by maximizing the adherence of the proposed contents with the particular preferences of every single user. However, traditional recommendation paradigms suffer from several drawbacks which are exacerbated in Cultural Heritage scenarios, due to the extremely wide range of users behaviors, which may also depend on their different educational backgrounds. In this paper, we propose a Hybrid recommender system which combines the four most common recommendation paradigms, namely collaborative filtering, popularit…

The effects of cryogenic cooling on surface integrity in hard machining: A comparison with dry machining

2012

Complexity and Action: Reflections on Decision Making and Cybernetics.

2013

This paper highlights some theoretical and epistemological reflections about the relevance of action for managerial studies. These reflections show how the cybernetic paradigm of complexity management can be used for better decision making that unites knowledge and action in a comprising, dynamic, and evolving approach. Cybernetics can help to overcome the fear of decision making in the face of uncertainty in complex scenarios, and can be an effective tool for improving the viability and competitiveness of firms in the twenty-first century.

Sub-Symbolic Mapping of Cyc Microtheories in Data-Driven 'Conceptual' Spaces

2007

The presented work aims to combine statistical and cognitive-oriented approaches with symbolic ones so that a conceptual similarity relationship layer can be added to a Cyc KB microtheory. Given a specific microtheory, a LSA-inspired conceptual space is inferred from a corpus of texts created using both ad hoc extracted pages from the Wikipedia repository and the built-in comments about the concepts of the specific Cyc microtheory. Each concept is projected in the conceptual space and the desired layer of sub-symbolic relationships between concepts is created. This procedure can help a user in finding the concepts that are "sub-symbolically conceptually related" to a new concept that he wan…

Cytotoxic effects of antibodies to proteinase 3 (C-ANCA) on human endothelial cells.

1994

SUMMARY Autoantibodies directed against cytoplasmic antigens of neutrophils (ANCA), especially those with specificity for proteinase 3 (PR-3) and myeloperoxidase, are valuable markers for differential diagnosis and monitoring of disease activity in Wegener's granulomatosis (WG) and other vasculitides. Till now, several concepts concerning a direct role of antibodies against PR-3 in the pathogenesis of WG have been discussed. Recently we were able to show that these antibodies recognize PR-3 translocated into the membrane of human endothelial cells. The aim of this study was to investigate putative cytotoxic effects of antibodies to PR-3 on human endothelial cells. Antibodies were obtained b…

Optimización del enriquecimiento de nauplios de Artemia mediante el uso de emulsiones lipídicas formuladas a partir de aceites sintéticos ricos en DHA

2015

Tesis llevada a cabo para conseguir el grado de Doctor por la Universidad de Valencia.--2016-01-29.--Sobresaliente Cum Laude

Parvovirus B19 nonstructural protein-induced damage of cellular DNA and resultant apoptosis.

2010

Parvovirus B19 is a widespread virus with diverse clinical presentations. The viral nonstructural protein, NS1, binds to and cleaves the viral genome, and induces apoptosis when transfected into nonpermissive cells, such as hepatocytes. We hypothesized that the cytotoxicity of NS1 in such cells results from chromosomal DNA damage caused by the DNA-nicking and DNA-attaching activities of NS1. Upon testing this hypothesis, we found that NS1 covalently binds to cellular DNA and is modified by PARP, an enzyme involved in repairing single-stranded DNA nicks. We furthermore discovered that the DNA nick repair pathway initiated by poly(ADPribose)polymerase and the DNA repair pathways initiated by …

Influence of molecular weight of DNA on the determination of anti-DNA antibodies in systemic lupus erythematosus (SLE) sera by radioimmunoassay

1975

Using a radioimmunoassay (RIA) based on the Farr technique with radioactively labeled 3-H-DNA for quantitative measurements of anti-DNA antibodies in sera of patients with systemic lupus erythematosus (SLE), the influence of molecular weight of DNA (ranging from 0.1 times 10-6 to 22.0 times 10-6 daltons) on binding and precipitation in this system has been investigated. Comparing our results with mathematical models it follows that one antibody molecule is fixed on the average to a statistical DNA segment of 2 times 10-6 to 4 times 10-6 daltons. Furthermore binding capacity of the DNA was found to be independent of the molecular weight, as demonstrated in a double label experiment using 14-…

T-DNA insertion alters the terpenoid content composition and bioactivity of transgenic Artemisia annua.

2014

In this study, the interference of T-DNA insertion upon Agrobacterium-mediated transformation on the biochemical expression of the host genome is discussed. Plant extracts of transgenic Artemisia annua L. with or without an overexpressed farnesyl pyrophosphate synthase gene have been investigated for their bioactivity and metabolic profile in comparison with wild type A. annua. The highest antimicrobial activity against Staphylococcus aureus, Bacillus subtilis and Candida albicans was observed in the T253 transgenic lines. Moreover, the crude extract from T253 showed higher antimalarial activity against the Plasmodium faciparum K1 strain than those of the others. The terpenoid constituents…