Search results for "terce"
showing 10 items of 394 documents
El acceso de las fundaciones al régimen fiscal privilegiado de las entidades no lucrativas : propuestas para su reforma
2022
La consecución de fines de interés general no es una tarea monopolizada por el Estado, sino que “se armoniza en una acción mutua estado-sociedad” (STC 18/1984) que precisa de un marco normativo adecuado, fiscalmente materializado en la Ley 49/2002 de Régimen fiscal de las entidades no lucrativas, la cual establece los requisitos para que, en particular, las fundaciones, puedan acceder al régimen fiscal privilegiado en ella contenido. Sin embargo, las deficiencias de técnica legislativa que presenta esta norma, la interpretación que de ella efectúa la DGT, -a través de un filtro de desconfianza hacia la sociedad civil- y su falta de acomodo, tras casi veinte años desde su promulgación, a la …
Disruption of apical-basal polarity of human embryonic stem cells enhances hematoendothelial differentiation
2007
Abstract During murine development, the formation of tight junctions and acquisition of polarity are associated with allocation of the blastomeres on the outer surface of the embryo to the trophoblast lineage, whereas the absence of polarization directs cells to the inner cell mass. Here, we report the results of ultrastructural analyses that suggest a similar link between polarization and cell fate in human embryos. In contrast, the five human embryonic stem cell (hESC) lines displayed apical-basal, epithelial-type polarity with electron-dense tight junctions, apical microvilli, and asymmetric distribution of organelles. Consistent with these findings, molecules that are components of tigh…
Dietary xenoestrogens differentially impair 3T3-L1 preadipocyte differentiation and persistently affect leptin synthesis
2008
International audience; Recent observations have highlighted adipogenesis alterations under exposure to several xenoestrogens at critical stages, and pointed at their possible involvement in the pathogenesis of obesity. However, it remains unclear whether these effects are mediated by classical estrogen receptor (ER) binding and subsequent transcriptional modulation. The aim of this study was to determine the (anti-)adipogenic impact of apigenin, bisphenol A, genistein and 17β-estradiol at the onset of adipose cell maturation, and to correlate it to their estrogenic potential. In steroid-free conditions, 3T3-L1 preadipocytes were induced to differentiate in the presence of xenoestrogens for…
Endothelin-1 modulates the expression of adhesion molecules on fibroblast-like synovial cells (FLS)
1996
Endothelin-1 is known to possess various biological properties. In the present study we have investigated the effects of Endothelin-1 (Et-1) on the expression of adhesion molecules ICAM-1, VCAM-1 and CD-44 by fibroblast-like synoviocytes. Cultured fibroblast-like synoviocytes were treated with Et-1 in the absence or presence of C1306, a specific endothelin-A-receptor antagonist. Cell surface expression of ICAM-1, VCAM-1 and CD-44 was determined by immunofluorescence studies, Cyto-ELISA and FACS-analysis. ICAM-1, VCAM-1 and CD-44 were constitutively expressed on cultured FLS. After incubation with Et-1 the expression of ICAM-1, VCAM-1 and CD-44 increased. The level of expression of adhesion …
α-Lipoic acid reduces expression of vascular cell adhesion molecule-1 and endothelial adhesion of human monocytes after stimulation with advanced gly…
1999
Advanced glycation end products (AGEs) have been identified as relevant mediators of late diabetic complications such as atherosclerotic disease. The endothelial migration of monocytes is one of the first steps in atherogenesis and monocyte-endothelial interaction itself is linked to the expression of adhesion molecules like vascular cell adhesion molecule-1 (VCAM-1). Recently, stimulation of VCAM-1 by AGEs has been demonstrated. Since endothelial stimulation by AGEs is followed by generation of oxygen free radicals with subsequent activation of nuclear transcription factor kappaB, we investigated the influence of alpha-lipoic acid on the expression of VCAM-1 and monocyte adherence to endot…
Differential regulation of endothelial cell adhesion molecule expression by nitric oxide donors and antioxidants.
1998
Although nitric oxide (NO) and antioxidants inhibit adhesion molecule expression, their inhibitory effects on nuclear factor kappaB (NF-kappaB) activation may differ. The NO donors, but not 8-bromo-cGMP, decreased tumor necrosis factor alpha (TNF-alpha)-induced VCAM-1, ICAM-1, and E-selectin expression by 11-70%. In contrast, NAC completely abolished VCAM-1 and E-selectin expression and decreased ICAM-1 expression by 56%. Gel shift assays demonstrate that NF-kappaB activation was inhibited by both NO and antioxidants. The activation of NF-kappaB involves the phosphorylation and degradation of its cytoplasmic inhibitor IkappaB-alpha by 26S proteasomes. The 26S proteasome inhibitor MG132 prev…
Endothelial adhesion molecules in essential hypertension: response to arginine infusion
2001
National report on third sector barriers in Spain
2016
Informe que realiza un diagnóstico de la situación del Tercer Sector en España en tres sectores, servicios sociales, deporte y cultura. Analiza el impacto de la crisis económica y las estrategias de resiliencia desarrolladas por las organizaciones del tercer sector. Informe sobre España del proyecto de investigación europea financiado por el 7º Programa marco y dirigido por el prof. Rafael Chaves Avila.
Determinantes de la calidad de vida percibida por los ancianos de una residencia de tercera edad en dos contextos socioculturales diferentes, España …
2009
La Tesis, analiza la influencia de diferentes variables sobre el nivel de calidad de vida que perciben los residentes de dos residencias de tercera edad ubicadas en España y Cuba respectivamente. La combinación de métodos de análisis cuantitativos y cualitativos para analizar la salud, la capacidad funcional, la dotación estructural y los recursos de ambos centros, así como las relaciones, las actividades diarias y la satisfacción con la vida, es uno de los aspectos más destacables de la investigación y trata de comprobar si la calidad de vida de las personas que viven en residencias de tercera edad, depende más directamente de los aspectos materiales y estructurales del centro o de otros a…
From Bi-Dimensionality to Uni-Dimensionality in Self-Report Questionnaires
2021
Abstract. The common factor model – by far the most widely used model for factor analysis – assumes equal item intercepts across respondents. Due to idiosyncratic ways of understanding and answering items of a questionnaire, this assumption is often violated, leading to an underestimation of model fit. Maydeu-Olivares and Coffman (2006) suggested the introduction of a random intercept into the model to address this concern. The present study applies this method to six established instruments (measuring depression, procrastination, optimism, self-esteem, core self-evaluations, and self-regulation) with ambiguous factor structures, using data from representative general population samples. I…