Search results for "terce"

Federico III e i monaci bianchi:la fondazione di Santa Maria di Altofonte

2011

Nel 1305 Federico III fonda l’abbazia di Santa Maria di Altofonte o de Parco e la affida ai monaci cistercensi. La fondazione avveniva a pochi anni dalla pace di Caltabellotta con l’intento di celebrare un sovrano riabilitato in ambito internazionale e di catalanizzare l’isola, ormai latinizzata ad opera degli ordini mendicanti. La dipendenza del monastero da quello catalano di Santes Creus completava il carattere celebrativo della fondazione sottolineando il legame di Federico III con i suoi progenitori e, quindi, la legittimità dinastica del sovrano, essendo Pietro III sepolto nell’abbazia catalana. Le numerose assegnazioni, i beni, i diritti, le immunità con cui il sovrano dotava nel 130…

La izquierda y lo social

2002

Francia, en vanguardia

2001

¿Qué hacer con Europa?

2005

El socialismo liberal / 4

2008

Regional and modular expression of morphogenetic factors in the demosponge Lubomirskia baicalensis

2008

Some sponges [phylum Porifera], e.g. the demosponges Lubomirskia baicalensis or Axinella polypoides, show an arborescent growth form. In the freshwater sponge L. baicalensis this morphotype is seen mostly in depths below 4 m while in more shallow regions it grows as a crust. The different growth forms are determined in nature very likely by water current and/or light. The branches of this species are composed of modules, arranged along the apical-basal axis. The modules are delimited by a precise architecture of the spicule bundles; longitudinal bundles originate from the apex of the earlier module, while at the basis of each module these bundles are cross-linked by traverse bundles under f…

Interaction mechanism of endogenous PP2A inhibitor protein ENSA with PP2A

2022

The vast diversity of protein phosphatase 2A (PP2A) holoenzyme composition ensures its multifaceted role in the regulation of cellular growth and signal transduction. In several pathological conditions, such as cancer, PP2A is inhibited by endogenous inhibitor proteins. Several PP2A inhibitor proteins have been identified, one of which is α-endosulfine (ENSA). ENSA inhibits PP2A activity when it is phosphorylated at Ser67 by Greatwall (Gwl) kinase. The role of ENSA in PP2A inhibition is rather well characterized, but knowledge of the mechanism of inhibition is scarce. In this study, we have performed comprehensive structural characterization of ENSA, and its interaction with PP2A A- and var…

Simplified Model to Predict Runoff Generation Time for Well-Drained and Vegetated Soils

2016

The study of generation process of subsurface stormflow, typical of well-drained and high permeable soils, can be theoretically carried out by applying the continuity and the motion equations with the appropriate boundary conditions. However, difficulties and uncertainness on determining soil hydraulic properties and soil physics heterogeneities let this way not always feasible. In a different way, processes dynamic can be derived by the local scale through a coarse graining procedure, allowing to preserve medium motion character, while hydraulic fluctuation of the motion are lost. Following an approach as this, in this paper a simplified model to predict the runoff generation time, the so-…

Lrp4, a Novel Receptor for Dickkopf 1 and Sclerostin, Is Expressed by Osteoblasts and Regulates Bone Growth and Turnover In Vivo

2009

Lrp4 is a multifunctional member of the low density lipoprotein-receptor gene family and a modulator of extracellular cell signaling pathways in development. For example, Lrp4 binds Wise, a secreted Wnt modulator and BMP antagonist. Lrp4 shares structural elements within the extracellular ligand binding domain with Lrp5 and Lrp6, two established Wnt co-receptors with important roles in osteogenesis. Sclerostin is a potent osteocyte secreted inhibitor of bone formation that directly binds Lrp5 and Lrp6 and modulates both BMP and Wnt signaling. The anti-osteogenic effect of sclerostin is thought to be mediated mainly by inhibition of Wnt signaling through Lrp5/6 within osteoblasts. Dickkopf1 …

A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration.

2004

A new system for lineage ablation is based on transgenic expression of a diphtheria toxin receptor (DTR) in mouse cells and application of diphtheria toxin (DT). To streamline this approach, we generated Cre-inducible DTR transgenic mice (iDTR) in which Cre-mediated excision of a STOP cassette renders cells sensitive to DT. We tested the iDTR strain by crossing to the T cell- and B cell-specific CD4-Cre and CD19-Cre strains, respectively, and observed efficient ablation of T and B cells after exposure to DT. In MOGi-Cre/iDTR double transgenic mice expressing Cre recombinase in oligodendrocytes, we observed myelin loss after intraperitoneal DT injections. Thus, DT crosses the blood-brain bar…