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Intranazāla metformīna efekti uz sporādiskās Alcheimera slimības tipa modeļa žurku telpisko atmiņu un neironu izdzīvošanu
2022
Alcheimera slimība ir visbiežāk sastopamā neirodeģeneratīvā saslimšana, kad lēni un pakāpeniski notiek neokortikāla smadzeņu šūnu atrofija, kas izpaužas kā kognīcijas pasliktināšanās. Balstoties uz glikozes metabolisma transporta izmaiņām Alcheimera slimības gadījumā, tiek pētītas vielas, piemēram, metformīns, kas spēj uzlabot insulīna sensitivitāti un mazināt neiroiekaisuma attīstību. Pētījuma rezultāti norāda, ka intranazāli ievadīts metformīns uzlabo intracerebroventrikulāri ievadīta neirotoksīna streptozocīna izraisīto telpiskās atmiņas un apmācīšanās pasliktināšanos žurkām Morisa ūdens labirinta testā, kā arī palielina dzīvotspējīgo neironu skaitu un samazina piknotisko neironu skaitu …
Amplicon-based high-throughput pooled sequencing identifies mutations in CYP7B1 and SPG7 in sporadic spastic paraplegia patients
2011
Hereditary spastic paraplegia (HSP) is a neurodegenerative disorder defined clinically by progressive lower limb spasticity and weakness. HSP is a genetically highly heterogeneous condition with at least 46 gene loci identified so far, involving X-linked, autosomal recessive (AR) and autosomal dominant inheritance. For correct diagnosis, molecular testing is essential because clinical parameters by themselves are not reliable to differentiate HSP forms. The purpose of this study was to establish amplicon-based high-throughput genotyping for AR-HSP. A sample of 187 index cases with apparently sporadic or recessive spastic paraplegia were analyzed by applying an array-based amplification stra…
The Italian Society of Gastroenterology (SIGE) and the Italian Group for the study of Inflammatory Bowel Disease (IG-IBD) Clinical Practice Guideline…
2010
Biological therapies are an important step in the management of Inflammatory Bowel Diseases. In consideration of high cost and safety issues there is the need to have clear recommendations for their use. Despite the American Gastroenterological Association and the European Crohn's and Colitis Organisation have published exhaustive Inflammatory Bowel Disease guidelines, national guidelines may be necessary as cultural values, economical and legal issues may differ between countries. For these reasons the Italian Society of Gastroenterology and the Italian Group for the study of Inflammatory Bowel Disease have decided to elaborate the Italian guidelines on the use of biologics in Inflammatory…
“Il Chisciotte in Spanglish tra riscrittura metatestuale e meticciamento metalinguistico: la sfida di Ilan Stavans".
2007
In un placete de La Mancha of which nombre no quiero remembrearme, vivía, not so long ago, uno de esos gentlemen… Così recita l’incipit del primo ed unico capitolo del Don Chisciotte, tradotto in Spanglish da Ilan Stavans con il titolo di Don Quixote de La Mancha. Lo Spanglish è un portmanteau dei termini Spanish (spagnolo) e English (Inglese), apparso per la prima volta tra il 1965 e il 1970 ed usato per riferirsi ad un fenomeno di contatto linguistico tipico, principalmente, della popolazione ispana in USA, la quale è esposta, parimenti, allo spagnolo e all’inglese. Lo Spanglish è il prodotto dell’interazione linguistica di comunità bilingue, si pensi a quelle stanziate presso il confine …
Recensione di Settinieri, Julia/Demirkaya, Sevilen/Feldmeier, Alexis/Gültekin-Karakoç/Riemer, Claudia (a cura di) (2014), Empirische Forschungsmethod…
2015
Recensione di Settinieri, Julia/Demirkaya, Sevilen/Feldmeier, Alexis/Gültekin-Karakoç/Riemer, Claudia (a cura di) (2014), Empirische Forschungsmethoden für Deutsch als Fremd- und Zweitsprache. Eine Einführung. Paderborn: Ferdinand Schöningh
Programmatūras lietojumkvalitātes metrikas un testēšanas veidi
2019
Darba mērķis bija izpētīt ISO/IEC 25022 standarta lietojumkvalitātes atribūtu metrikas un veidus, kā varētu veikt testēšanu dažādajiem lietojumkvalitātes atribūtiem, kā arī izpētīt to popularitāti interneta vietnēs starp zinātniskajiem rakstiem un starp bloga rakstiem. Ir apkopota informācija par izmantojamajām testēšanas metodēm un nepieciešamo datu ieguves veidiem. Darbā ir izpētīti lietojumkvalitātes atribūtu testēšanas veidi un pielietojamās metrikas programmatūras lietojumkvalitātes novērtēšanai. Ir tikusi iegūta statistika popularitātes pieaugumam gan zinātniskajos avotos, gan bloga rakstos galvenajiem lietojumkvalitātes atribūtiem – rezultativitāte, efektivitāte, apmierinātība, riskb…
Programmatūras testēšanas procesa metriku analīze
2019
Programmatūras izstrādes dzīves cikla neatņemama sastāvdaļa ir testēšana un kvalitātes nodrošināšana. Mūsdienu straujajā attīstības periodā, kad nelieli uzņēmumi strauji izaug, tad par testēšanas procesu bieži vien netiek domāts. Tā tiek atlikta otrajā plānā, bet, kā pieredze rāda, tad tas nav labākais veids. Tajā posmā, kad testēšana jau ir ieviesta, pazūd kontrole un pārskatāmība. Lai veiktu kaut kādu kontroli, lai būtu iespējams ielikt rāmjos un nomērīt paveikto, tiek plaši pielietotas dažādas metrikas. Metrikas var raksturot dažādus raksturlielumus, piemēram, apjomu vai skaitu. Izstrādes procesi mēdz būt dažādi, tāpēc arī metrika…
Scientific Opinion addressing the state of the science on risk assessment of plant protection products for in‐soil organisms
2017
Abstract Following a request from EFSA, the Panel on Plant Protection Products and their Residues developed an opinion on the science behind the risk assessment of plant protection products for in‐soil organisms. The current risk assessment scheme is reviewed, taking into account new regulatory frameworks and scientific developments. Proposals are made for specific protection goals for in‐soil organisms being key drivers for relevant ecosystem services in agricultural landscapes such as nutrient cycling, soil structure, pest control and biodiversity. Considering the time‐scales and biological processes related to the dispersal of the majority of in‐soil organisms compared to terrestrial non…
Infective Endocarditis: Preliminary Results of a Cohort Study in the Southern Italian Population.
2020
Background Infective endocarditis (IE) is an uncommon disease with an involved interplay of clinical and surgical team management. We aimed to define diagnosis parameters and delineate in-hospital management in patients with IE admitted in a tertiary hospital of Southern Italian. Materials and methods Fifty-six consecutive patients (42 males, 14 females; age range: 34-85 years) admitted for IE in the Infectious Diseases, Cardiac Surgery, and Cardiology units, between January 2011 and August 2017, were enrolled. Demographic data, mortality, comorbidities, specimen type, microscopy results, special histological staining performed, and antimicrobial therapy were collected and analyzed. Any com…