Search results for "testi"

Influence of orange cultivar and mandarin postharvest storage on polyphenols, ascorbic acid and antioxidant activity during gastrointestinal digestio…

2017

Polyphenols, ascorbic acid content and antioxidant activity of two sweet oranges (Navel-N and Cara Cara-CC) and mandarin (Clementine-M) as well as their bioaccessibilities were evaluated in pulps and compared to those in fresh juice. Thus, pulps of oranges and mandarins displayed higher hesperidin (HES), narirutin (NAR), total flavonoids (TF), total phenols (TP) and antioxidant activity (AAC) than their corresponding juices. Also, CC products presented higher bioactive compounds content than N ones. Bioaccessibility of bioactive compounds and AAC were higher in pulps of both oranges and mandarin than in their corresponding juices. Oranges (N and CC) pulps and juices presented higher bioacce…

A new paradigm for pattern classification: Nearest Border Techniques

2013

Published version of a chapter in the book: AI 2013: Advances in Artificial Intelligence. Also available from the publisher at: http://dx.doi.org/10.1007/978-3-319-03680-9_44 There are many paradigms for pattern classification. As opposed to these, this paper introduces a paradigm that has not been reported in the literature earlier, which we shall refer to as the Nearest Border (NB) paradigm. The philosophy for developing such a NB strategy is as follows: Given the training data set for each class, we shall first attempt to create borders for each individual class. After that, we advocate that testing is accomplished by assigning the test sample to the class whose border it lies closest to…

87 Topical Seminar Summary: QUANTITATIVE SENSORY TESTING (QST) IN PAIN MEDICINE: WHAT IS ITS VALUE IN CLINICAL PRACTICE?

2006

Factors influencing inclusion in digestive cancer clinical trials: A population-based study

2015

Inclusion in a randomized therapeutic trial represents an optimal therapeutic strategy.To determine the influence of demographic characteristics and deprivation on the enrolment of patients in digestive cancer clinical trials.Between 2004 and 2010, 4632 patients were recorded by the Burgundy Digestive Cancer Registry. According to a balancing score, the 136 patients included in a clinical trial were matched with 272 patients who met the eligibility criteria for trials. Deprivation was measured by the ecological European deprivation index. A conditional multivariate logistic regression was performed.Patients aged over 75 years were significantly less likely to be included in clinical trials …

Adaptive trial design: a general methodology for censored time to event data.

2008

Adaptive designs allow a clinical trial design to be changed according to interim findings without inflating type I error. The Inverse Normal method can be considered as an adaptive generalization of classical group sequential designs. The use of the Inverse Normal method for censored survival data was demonstrated only for the logrank statistic. However, the logrank statistic is inefficient in the presence of nuisance covariates affecting survival. We demonstrate, how the Inverse Normal method can be applied to Cox regression analysis. The required independence between test statistics of the different stages of the trial can be obtained by two different approaches. One is using the indepen…

The ocular manifestations in IBD screening (OMIS) questionnaire: pilot study on detection of ocular involvement in inflammatory bowel diseases.

2020

Purpose: To assess the usefulness of a dedicated questionnaire for patients with inflammatory bowel diseases (IBD) treated with biological drugs for the detection of ocular extraintestinal manifestations (EIMs). IBD can cause extraintestinal symptoms including ocular complaints which are frequently ignored and may be associated with significant morbidity, including blindness. Methods: We developed a questionnaire, named Ocular Manifestations in IBD Screening (OMIS) questionnaire, after agreement between gastroenterologists and ophthalmologists. The questionnaire was administered by a non-ophthalmologist physician to 96 IBD patients treated with biological drugs. Results: 35 patients (36.5%)…

V: p-Werte: Was sie besagen und was nicht …

2002

Both an extensive data description and an explicit assessment of a study result's statistical significance should be presented in the result section of a clinical trial report. Whereas the description illustrates the order and clinical relevance of the study findings, the statistical significance describes its generalizability to patients not included in the clinical trial: Despite the random recruitment of patients into a trial, the study results may fail to represent clinical reality (for example the trial might show falsely positive efficacy findings, whereas in "clinical reality" efficacy appears rather limited). A p value measures the statistical significance of a study result -- the s…

Digestive disorders and Intestinal microbiota

2018

In the last decade, a barge body of scientific literature has suggested that specific alterations of the gut microbiota may be associated with ther development and clinical course of several gastrointestinal diseases, including irritable bowel syndrome, inflammatory bowel disease, celiac disease, gastrointestinal cancer and Clostridium difficile infection. These alterations are often referred to as “dysbiosis”, a generic term designing reduction of gut microbiota biodiversity and alterations in its composition. Here, we provide a synthetic overview of the key concepts on the relationship between intestinal microbiota and gastrointestinal diseases, focusing on the translation of these concep…

Distributing Storage in Cloud Environments

2013

Cloud computing has a major impact on today's IT strategies. Outsourcing applications from IT departments to the cloud relieves users from building big infrastructures as well as from building the corresponding expertise, and allows them to focus on their main competences and businesses. One of the main hurdles of cloud computing is that not only the application, but also the data has to be moved to the cloud. Networking speed severely limits the amount of data that can travel between the cloud and the user, between different sites of the same cloud provider, or indeed between different cloud providers. It is therefore important to keep applications near the data itself. This paper investig…

FederatedCloudSim

2014

Recent developments show that the standardization of cloud service descriptions and exchange leads the way for the rise of cloud federations. In these federations CSPs (cloud service providers) can use resources of other CSPs in the case of a lack of local resources or they can add remote services to their catalogue. Cloud federations again demand for cloud brokers which offer the resources and services of different CSPs transparently to the users. Research of cloud federations in the real world is very complex and expensive as distributed hard- and software scenarios are needed. Therefore we present FederatedCloudSim, a very flexible cloud simulation framework that can be used to simulate …