Search results for "testing."

Semiquantitative multiplex PCR: a useful tool for large rearrangement screening and characterization

2006

Methods presently employed for detection of large rearrangements have several drawbacks, such as the amount of sample and time required, technical difficulty, or the probability of false-negative carriers. Using the low-density-lipoprotein receptor (LDLR) gene, whose mutations are responsible for familial hypercholesterolemia (FH), we have developed a procedure to detect large rearrangements in this gene based on semiquantitative PCR, with important improvements as compared to previous methods. Our method covers the complete LDLR gene and introduces an internal control in the reaction. The procedure discriminates the four different large rearrangements (two deletions and two insertions) tha…

Relationship status and respiratory diseases: an analysis on a general population sample

2021

Background: Very few studies have examined whether marital/relationship status affects respiratory diseases. Objective: Assess the association of relationship status (Rstatus: domestic partnership/civil union/marriage, cohabitation with non-partners, being single) with current (CA) and past asthma (PA), allergic (AR) and non-allergic rhinitis (NAR), and chronic bronchitis (CB). Methods: Data were collected in the frame of GEIRD, a population-based, multicase-control survey. Among 2531 subjects (age 21–86, female 50%) who underwent standardized interviews, skin prick and lung function tests, 575 cases of CA, 268 cases of PA, 968 cases of AR, 462 cases of NAR, 265 cases of CB without airflow …

Calorimetric and structural investigation of the interaction between bovine serum albumin and high molecular weight dextran in water.

2005

This work studies specific interactions between a small globular protein and a highly flexible, branched polysaccharide using differential scanning calorimetry (DSC), circular dichroism (CD), fluorescence, and turbidimetry measurements. It uses the system water/bovine serum albumin (BSA)/dextran (D 2000) as a model. Dextran molecules are able to form interpolymeric complexes with BSA in water at both low and high temperatures if the polysaccharide is in excess and if the protein exists in its associated state. It leads to a partial destabilization of the secondary and tertiary structures of the protein and an additional exposure of the hydrophobic tryptophan residues to the surface of globu…

A new paradigm for pattern classification: Nearest Border Techniques

2013

Published version of a chapter in the book: AI 2013: Advances in Artificial Intelligence. Also available from the publisher at: http://dx.doi.org/10.1007/978-3-319-03680-9_44 There are many paradigms for pattern classification. As opposed to these, this paper introduces a paradigm that has not been reported in the literature earlier, which we shall refer to as the Nearest Border (NB) paradigm. The philosophy for developing such a NB strategy is as follows: Given the training data set for each class, we shall first attempt to create borders for each individual class. After that, we advocate that testing is accomplished by assigning the test sample to the class whose border it lies closest to…

87 Topical Seminar Summary: QUANTITATIVE SENSORY TESTING (QST) IN PAIN MEDICINE: WHAT IS ITS VALUE IN CLINICAL PRACTICE?

2006

Adaptive trial design: a general methodology for censored time to event data.

2008

Adaptive designs allow a clinical trial design to be changed according to interim findings without inflating type I error. The Inverse Normal method can be considered as an adaptive generalization of classical group sequential designs. The use of the Inverse Normal method for censored survival data was demonstrated only for the logrank statistic. However, the logrank statistic is inefficient in the presence of nuisance covariates affecting survival. We demonstrate, how the Inverse Normal method can be applied to Cox regression analysis. The required independence between test statistics of the different stages of the trial can be obtained by two different approaches. One is using the indepen…

Distributing Storage in Cloud Environments

2013

Cloud computing has a major impact on today's IT strategies. Outsourcing applications from IT departments to the cloud relieves users from building big infrastructures as well as from building the corresponding expertise, and allows them to focus on their main competences and businesses. One of the main hurdles of cloud computing is that not only the application, but also the data has to be moved to the cloud. Networking speed severely limits the amount of data that can travel between the cloud and the user, between different sites of the same cloud provider, or indeed between different cloud providers. It is therefore important to keep applications near the data itself. This paper investig…

FederatedCloudSim

2014

Recent developments show that the standardization of cloud service descriptions and exchange leads the way for the rise of cloud federations. In these federations CSPs (cloud service providers) can use resources of other CSPs in the case of a lack of local resources or they can add remote services to their catalogue. Cloud federations again demand for cloud brokers which offer the resources and services of different CSPs transparently to the users. Research of cloud federations in the real world is very complex and expensive as distributed hard- and software scenarios are needed. Therefore we present FederatedCloudSim, a very flexible cloud simulation framework that can be used to simulate …

Self-establishing a Service Level Agreement within Autonomic Cloud Networking Environment

2014

International audience; Today, cloud networking which is the ability to connect the user with his cloud services and to interconnect these services within an inter-cloud approach, is one of the recent research areas in the cloud computing research communities. The main drawback of cloud networking consists in the lack of Quality of Service (QoS) guarantee and management in conformance with a corresponding Service Level Agreement (SLA). Several research works have been proposed for the SLA establishing in cloud computing, but not in cloud networking. In this paper, we propose an architecture for self-establishing an end-to-end service level agreement between a Cloud Service User (CSU) and a …

Autonomic Brokerage Service for an End-to-End Cloud Networking Service Level Agreement

2014

8 pages; International audience; Today, cloud networking which is the ability to connect the user with his cloud services and to interconnect these services within an inter-cloud approach, is one of the recent research areas in the cloud computing research communities. The main drawback of cloud networking consists in the lack of Quality of Service (QoS) assurance and management in conformance with a corresponding Service Level Agreement (SLA). In this paper, we propose a framework for self-establishing an end-to-end service level agreement between a Cloud Service User (CSU) and multiple Cloud Service Providers (CSPs) in a cloud networking environment using brokerage service. We focus on Qo…