Search results for "thermal"

showing 10 items of 3576 documents

Friction Model for Tool/Work Material Contact Applied to Surface Integrity Prediction in Orthogonal Cutting Simulation

2017

Abstract Tribological behavior at both tool/chip and tool/work material interfaces should be highly considered while simulating the machining process. In fact, it is no longer accurate to suppose one independent constant friction coefficient at the tool/chip interface, since in reality it depends on the applied contact conditions, including the sliding velocity and pressure. The contact conditions at both above mentioned interfaces may affect the thermal and mechanical phenomena and consequently the surface integrity predictions. In this article, the influence of contact conditions (sliding velocity) on the tribological behavior of uncoated tungsten carbide tool against OFHC copper work mat…

0209 industrial biotechnologyWork (thermodynamics)Matériaux [Sciences de l'ingénieur]Materials scienceMechanical Phenomenachemistry.chemical_element02 engineering and technologytribology testschemistry.chemical_compound020901 industrial engineering & automation0203 mechanical engineeringcarbide toolTungsten carbideThermalComposite materialGeneral Environmental Sciencecutting simulationfriction modelingMécanique [Sciences de l'ingénieur]MetallurgyOFHC copperTribologyChipCopper020303 mechanical engineering & transportschemistryGeneral Earth and Planetary SciencesSurface integrityProcedia CIRP
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Cytosine methylation patterns suggest a role of methylation in plastic and adaptive responses to temperature in European grayling (Thymallus thymallu…

2020

Temperature is a key environmental parameter affecting both the phenotypes and distributions of organisms, particularly ectotherms. Rapid organismal responses to thermal environmental changes have been described for several ectotherms; however, the underlying molecular mechanisms often remain unclear. Here, we studied whole genome cytosine methylation patterns of European grayling (Thymallus thymallus) embryos from five populations with contemporary adaptations of early life history traits at either 'colder' or 'warmer' spawning grounds. We reared fish embryos in a common garden experiment using two temperatures that resembled the 'colder' and 'warmer' conditions of the natal natural enviro…

0301 basic medicineCancer ResearchDATABASEsalmonidPopulationCytosine methylationSNPepigenetic variationCytosine03 medical and health sciences0302 clinical medicineINTRAGENIC DNA METHYLATIONthermal adaptationPHENOTYPIC PLASTICITYAnimalsADAPTATIONeducationMolecular BiologyGENE-EXPRESSIONLocal adaptationeducation.field_of_studyPhenotypic plasticitypromoterCLIMATE-CHANGEbiologyTemperatureGenetic VariationDNA Methylationbiology.organism_classificationThymallusEVOLUTIONEuropean graylingINSIGHTS030104 developmental biologyCpG siteEvolutionary biologydevelopmental plasticity030220 oncology & carcinogenesisEctotherm1181 Ecology evolutionary biologyDNA methylationTHERMAL PLASTICITYtranscriptionSalmonidaeResearch PaperEpigenetics
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Carbon Nanodots for On Demand Chemophotothermal Therapy Combination to Elicit Necroptosis: Overcoming Apoptosis Resistance in Breast Cancer Cell Lines

2020

Background: Engineered luminescent carbon nanodots (CDs) are appealing nanomaterials for cancer image-guided photothermal therapy combining near infrared (NIR)&ndash

0301 basic medicineCancer ResearchtheranosticsNecroptosisanticancer phototherapynecroptosisSettore BIO/11 - Biologia Molecolare02 engineering and technologylcsh:RC254-282Article03 medical and health sciencesRIPK1breast cancermedicineirinotecan;carbon nanodotsirinotecanChemistrygene expression analysesCancerPhotothermal therapy021001 nanoscience & nanotechnologymedicine.diseaselcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogensIrinotecan030104 developmental biologyOncologySettore CHIM/09 - Farmaceutico Tecnologico ApplicativoApoptosisDrug deliveryCancer cellCancer research0210 nano-technologymedicine.drugCancers
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Thermal stability of nacre proteins of the polynesian pearl oyster: a proteomic study.

2015

Mollusc shells are organic-inorganic composites that are often preserved in the fossil record. However, the way the organic fraction, also called shell matrix, gets fossilized remains an unsolved question, in spite of several old and more recent studies. In the present paper, we have tried to mimic a diagenetic process by constantly heating for ten days at 100°C fresh nacre powder samples of the Polynesian pearl oyster Pinctadamargaritifera. Each day, aliquots of nacre powder were sampled and the matrix was subsequently extracted. It was further analysed by direct weigh quantification, by immunological techniques and by proteomics. Our preliminary data suggest that nacre proteins, when heat…

0301 basic medicineChromatographyFossil RecordbiologyMechanical EngineeringPearl oysterPinctada margaritiferaMineralogyProtein degradationbiology.organism_classification[ SDV.IB.BIO ] Life Sciences [q-bio]/Bioengineering/BiomaterialsOrganic fraction[SDV.IB.BIO] Life Sciences [q-bio]/Bioengineering/Biomaterials03 medical and health scienceschemistry.chemical_compound030104 developmental biologyCalcium carbonatechemistryMechanics of Materials[ SDV.BBM.GTP ] Life Sciences [q-bio]/Biochemistry Molecular Biology/Genomics [q-bio.GN][SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry Molecular Biology/Genomics [q-bio.GN]General Materials ScienceThermal stabilityComputingMilieux_MISCELLANEOUSBiomineralization
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Cysteine, glutathione and a new genetic code: biochemical adaptations of the primordial cells that spread into open water and survived biospheric oxy…

2019

Abstract Life most likely developed under hyperthermic and anaerobic conditions in close vicinity to a stable geochemical source of energy. Epitomizing this conception, the first cells may have arisen in submarine hydrothermal vents in the middle of a gradient established by the hot and alkaline hydrothermal fluid and the cooler and more acidic water of the ocean. To enable their escape from this energy-providing gradient layer, the early cells must have overcome a whole series of obstacles. Beyond the loss of their energy source, the early cells had to adapt to a loss of external iron-sulfur catalysis as well as to a formidable temperature drop. The developed solutions to these two problem…

0301 basic medicineClinical BiochemistryBiochemistry03 medical and health scienceschemistry.chemical_compound0302 clinical medicineCysteineMolecular Biologychemistry.chemical_classificationMethionineSelenocysteinebiologyWaterGlutathionebiology.organism_classificationAdaptation PhysiologicalGlutathioneAmino acidOxygen030104 developmental biologychemistryGenetic CodeBiophysicsEnergy source030217 neurology & neurosurgeryCysteineArchaeaHydrothermal ventBiological Chemistry
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Long-range vortex transfer in superconducting nanowires

2019

Under high-enough values of perpendicularly-applied magnetic feld and current, a type-II superconductor presents a fnite resistance caused by the vortex motion driven by the Lorentz force. To recover the dissipation-free conduction state, strategies for minimizing vortex motion have been intensely studied in the last decades. However, the non-local vortex motion, arising in areas depleted of current, has been scarcely investigated despite its potential application for logic devices. Here, we propose a route to transfer vortices carried by non-local motion through long distances (up to 10 micrometers) in 50nm-wide superconducting WC nanowires grown by Ga+ Focused Ion Beam Induced Deposition.…

0301 basic medicineElectronic properties and materialsNanowirelcsh:MedicineArticleSuperconducting properties and materials03 medical and health sciencessymbols.namesake0302 clinical medicineElectrical resistance and conductanceCondensed Matter::Superconductivitylcsh:ScienceSuperconductivityPhysicsMultidisciplinaryCondensed matter physicsNanowireslcsh:RFísicaVorticityThermal conductionVortexMagnetic field030104 developmental biologysymbolslcsh:QEngineering sciences. TechnologyLorentz force030217 neurology & neurosurgery
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Drying parameters greatly affect the destruction of Cronobacter sakazakii and Salmonella Typhimurium in standard buffer and milk

2017

International audience; Salmonella Typhimurium and Cronobacter sakazakii are two foodborne pathogens involved in neonatal infections from milk powder and infant formula. Their ability to survive in low-moisture food and during processing from the decontamination to the dried state is a major issue in food protection. In this work, we studied the effects of the drying process on Salmonella Typhimurium and Cronobacter sakazakii, with the aim of identifying the drying parameters that could promote greater inactivation of these two foodborne pathogens. These two bacteria were dried under different atmospheric relative humidities in milk and phosphate-buffered saline, and the delays in growth re…

0301 basic medicineEnterobacter-sakazakiiSevere dehydrationSalmonellaWater activitySurvivalMicroorganismDesiccation tolerance030106 microbiologyResistanceDrying conditionsLow-moisture foodsInfant formulasBuffersmedicine.disease_causeMicrobiologyMicrobiologyCultivability03 medical and health sciencesCronobacter sakazakiiStrain variabilitymedicineAnimalsFood scienceDesiccationThermal-destructionMicrobial Viabilitybiologybusiness.industry[ SDV.IDA ] Life Sciences [q-bio]/Food engineeringHuman decontaminationFood safetybiology.organism_classificationCronobacter sakazakiiKineticsMilkInfant formulaSalmonella TyphimuriumFood MicrobiologybusinessBacteriaFood ScienceWater activity
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Surface Micro Discharge–Cold Atmospheric Pressure Plasma Processing of Common House Cricket Acheta domesticus Powder: Antimicrobial Potential and Lip…

2021

The growing world population and the need to reduce the environmental impact of food production drive the exploration of novel protein sources. Insects are being cultivated, harvested, and processed to be applied in animal and human nutrition. The inherent microbial contamination of insect matrices requires risk management and decontamination strategies. Thermal sterilization results in unfavorable cooking effects and oxidation of fatty acids. The present study demonstrates the risk management in Acheta domesticus (home cricket) powder with a low-energy (8.7–22.0 mW/cm2, 5 min) semi-direct surface micro discharge (SMD)–cold atmospheric pressure plasma (CAPP). At a plasma power density lower…

0301 basic medicineHistologyAcheta domesticusBiomedical EngineeringBacillus cereusinsect powderBioengineeringAtmospheric-pressure plasmaBacillus subtilisMass spectrometrycold plasmaMicrobial decontaminationFood safetylipids03 medical and health sciences0404 agricultural biotechnologyHouse cricketFood scienceBacillus megaterium2. Zero hunger030109 nutrition & dieteticsbiologyChemistryfungimicrobial decontamination04 agricultural and veterinary sciencesSterilization (microbiology)biology.organism_classificationNon-thermal processing040401 food scienceLipids3. Good healthfood safety13. Climate actionAchetaCold plasmaInsect powderTP248.13-248.65BiotechnologyFrontiers in Bioengineering and Biotechnology
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Cultivation trials of hop (Humulus lupulus L.) in semi-arid environments

2020

Abstract The recent developments in the market and craft beer industry in Italy have led to an increasing demand for local raw materials, such as barley malt and hops. Few works have been addressed to evaluate suitability and productivity of hop in semi-arid Italian environments. With this purpose, two experiments were carried out in 2018 and 2019, testing the suitability to cultivation of three commonly used hop varieties (Cascade, Chinook and Nuggett) in two typical semi-arid environments in Sicily. Phenological stages were also evaluated, and GDDs accumulated in vegetative and reproductive stages were calculated according to 9 different methods, dealing with three Tbase temperatures (0 °…

0301 basic medicineHumulus lupulusThermal sumsOrganolepticCraft beerSensory analysisHop (networking)Crop03 medical and health sciences0302 clinical medicineYield (wine)lcsh:Social sciences (General)lcsh:Science (General)MathematicsMultidisciplinarybiologyPhenologyCrop yieldDevelopment stagesMediterranean agro-ecosystemsbiology.organism_classificationAgronomySettore AGR/02 - Agronomia E Coltivazioni ErbaceeHorticulture030104 developmental biologyAgricultural sciencelcsh:H1-99Craft beer Mediterranean agro-ecosystems Thermal sums Development stages Agricultural science Agronomy Crop production Crop quality Crop yields030217 neurology & neurosurgerylcsh:Q1-390Heliyon
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Analysis of substrate binding in individual active sites of bifunctional human ATIC

2018

Aminoimidazolecarboxamide ribonucleotide formyl transferase (AICARFT): Inosine monophosphate cyclohydrolase (IMPCH, collectively called ATIC) is a bifunctional enzyme that catalyses the penultimate and final steps in the purine de novo biosynthesis pathway. The bifunctional protein is dimeric and each monomer contains two different active sites both of which are capable of binding nucleotide substrates, this means to a potential total of four distinct binding events might be observed. Within this work we used a combination of site-directed and truncation mutants of ATIC to independently investigate the binding at these two sites using calorimetry. A single S10W mutation is sufficient to blo…

0301 basic medicineHydroxymethyl and Formyl TransferasesModels MolecularRibonucleotideStereochemistryBiophysicsBiochemistryAnalytical ChemistrySubstrate Specificity03 medical and health scienceschemistry.chemical_compoundMultienzyme ComplexesCatalytic DomainTransferaseHumansNucleotidePhosphofructokinase 2Bifunctional enzymesMolecular Biologychemistry.chemical_classification030102 biochemistry & molecular biologybiologyNucleotidesActive siteCooperative bindingIsothermal titration calorimetryXanthosine monophosphate030104 developmental biologyBiochemistrychemistryNucleotide DeaminasesMultiple binding sitesbiology.proteinIsothermal titration calorimetryProtein Binding
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