Search results for "thing"

Outcome of liver transplantation for hepatopulmonary syndrome: a Eurotransplant experience.

2019

Hepatopulmonary syndrome (HPS) is a pulmonary vascular complication of liver disease that affects up to 30% of patients with cirrhosis [1]. Intrapulmonary vascular dilatations and shunts result in gas exchange abnormalities, ranging from elevated alveolar-arterial oxygen gradients with no hypoxemia to very severe hypoxemia [1, 2]. Currently, liver transplantation (LT) is the only treatment option [3]. The Model for End-Stage Liver Disease (MELD) is a scoring system for assessing liver disease severity that has been validated to predict the 3-months waitlist mortality, and is used by Eurotransplant for prioritising allocation of liver transplants [4]. Footnotes This manuscript has recently b…

Linezolid and atorvastatin impact on pneumonia caused by Staphyloccocus aureus in rabbits with or without mechanical ventilation

2017

International audience; Pneumonia may involve methicillin-resistant Staphylococcus aureus (MRSA), with elevated rates of antibiotics failure. The present study aimed to assess the effect of statins given prior to pneumonia development. Spontaneously breathing (SB) or mechanically ventilated (MV) rabbits with pneumonia received atorvastatin alone, linezolid (LNZ) alone, or a combination of both (n = 5 in each group). Spontaneously breathing and MV untreated infected animals (n = 11 in each group), as well as uninfected animals (n = 5 in each group) were used as controls. Microbiological features and inflammation were evaluated. Data are presented as medians (interquartile range). Linezolid a…

Clinical reappraisal of SHORT syndrome withPIK3R1mutations: toward recommendation for molecular testing and management

2015

SHORT syndrome has historically been defined by its acronym: short stature (S), hyperextensibility of joints and/or inguinal hernia (H), ocular depression (O), Rieger abnormality (R) and teething delay (T). More recently several research groups have identified PIK3R1 mutations as responsible for SHORT syndrome. Knowledge of the molecular etiology of SHORT syndrome has permitted a reassessment of the clinical phenotype. The detailed phenotypes of 32 individuals with SHORT syndrome and PIK3R1 mutation, including eight newly ascertained individuals, were studied to fully define the syndrome and the indications for PIK3R1 testing. The major features described in the SHORT acronym were not unive…

2020

Background To date, microRNAs (miRs) carried in extracellular vesicles (EVs) in response to exercise have been studied in blood but not in non-invasively collectable body fluids. In the present study, we examined whether six exercise-responsive miRs, miRs-21, -26, -126, -146, -221, and -222, respond to acute endurance exercise stimuli of different intensities in sweat. Methods We investigated the response of miRs isolated from sweat and serum EVs to three endurance exercise protocols: (1) maximal aerobic capacity (VO2max ), (2) anaerobic threshold (AnaT), and (3) aerobic threshold (AerT) tests. Sauna bathing was used as a control test to induce sweating through increased body temperature in…

Corticoperipheral neuromuscular disconnection in obstructive sleep apnoea.

2020

Abstract The roles of central nervous mechanisms and cortical output in obstructive sleep apnoea remain unclear. We addressed corticomuscular coupling between cortical sensorimotor areas and lower facial motor units as a mechanistic pathway and as a possible surrogate marker of corticoperipheral motor control in obstructive sleep apnoea. In this exploratory cross-sectional retrospective study, we analysed EEG (C3 and C4 leads) and chin EMG from polysomnography recordings in 86 participants (22 females; age range: 26–81 years): 27 with mild (respiratory disturbance index = 5–15 events/h), 21 with moderate (15–30 events/h) and 23 with severe obstructive sleep apnoea (>30 events/h) and 15 cont…

Autonomic Modulation Improves in Response to Harder Performances While Playing Wind Instruments

2020

Background: Despite inducing autonomic benefits similar to exercise, playing wind instruments is a physical, and cognitive task of high attentional requirements, which demands musicians maximal efforts, leading to sympathetic hyperarousal and autonomic worsening. In this context of controversy, it remains unknown the autonomic response to playing highly demanding music performances, as compared to an easier one, which might be of interest in wind musicians' cardiovascular health. Objectives: This study aimed to investigate differences in the autonomic control of the heart with regard to task demands (TD), avoiding emotional influences (rehearsal performance). Methods: Eight healthy male pro…

A Clustering approach for profiling LoRaWAN IoT devices

2019

Internet of Things (IoT) devices are starting to play a predominant role in our everyday life. Application systems like Amazon Echo and Google Home allow IoT devices to answer human requests, or trigger some alarms and perform suitable actions. In this scenario, any data information, related device and human interaction are stored in databases and can be used for future analysis and improve the system functionality. Also, IoT information related to the network level (wireless or wired) may be stored in databases and can be processed to improve the technology operation and to detect network anomalies. Acquired data can be also used for profiling operation, in order to group devices according…

The leftovers. The dead in life and social disappearance.

2020

Through an analysis of the TV series The Leftovers, we delve into the concept of "social disappearance" and into how it expresses the limits between life and death. The analysis focuses on the event that drives the plot: the mass disappearance of millions of people without reason. It has three moments: (1) the reconstruction of the order that the disappearance has broken; (2) the deviation of the mourning processes from their original logic; and (3) the acceptance that in the post-disappearance world nothing will be the same as before. The text offers some suggestions for thinking about possible lives in a world that is broken and with no promise of reconstruction, a world in which "social …

‘He is Quirky; He is the World's Greatest Psychologist’: On the Community of Those Who Have Nothing in Common

2016

In this article, we challenge the concept of the therapeutic relationship as an operationalisable entity. In contrast to this idea, we introduce Alphonso Lingis’ concept of community, and his distinction between the rational community and the community of those who have nothing in common. This is done through speculative analysis of a transcribed sequence from a research interview with a boy who speaks about his experiences of receiving mental health care. This boy and his family were helped through a network-oriented, dialogical approach. In the sequence highlighted here, the boy speaks of the significance of a particular mental health practitioner. The boy expresses appreciation for the h…

Favouring emotional processing in improvisational music therapy through resonance frequency breathing: a single-case experimental study with a health…

2017

Resonance frequency breathing (RFB) is a form of slow breathing at around six breaths/min, whose immediate effects are to substantially increase heart rate variability (HRV) and to reduce stress levels. Since RFB has already been successfully used on its own to treat various emotional disorders, we wanted to evaluate its effect on emotional processing when used as a preparatory intervention in improvisational music therapy. To do so, we performed a single-subject experimental study with a healthy participant. We hypothesised that RFB would serve both as an emotional catalyst and emotional regulator, the actual outcome depending on the client’s current issues and needs. The study consisted o…