Search results for "throughput"

showing 10 items of 483 documents

Penalized classification for optimal statistical selection of markers from high-throughput genotyping: application in sheep breeds

2018

The identification of individuals’ breed of origin has several practical applications in livestock and is useful in different biological contexts such as conservation genetics, breeding and authentication of animal products. In this paper, penalized multinomial regression was applied to identify the minimum number of single nucleotide polymorphisms (SNPs) from high-throughput genotyping data for individual assignment to dairy sheep breeds reared in Sicily. The combined use of penalized multinomial regression and stability selection reduced the number of SNPs required to 48. A final validation step on an independent population was carried out obtaining 100% correctly classified individuals. …

0301 basic medicinepenalized multinomial regression stability selection sheep breeds livestock genetic resources single nucleotide polymorphism markersGenotypePopulationSingle-nucleotide polymorphismComputational biologyBreedingBiologySF1-1100Polymorphism Single Nucleotidesheep breeds03 medical and health sciencesSettore AGR/17 - Zootecnica Generale E Miglioramento Geneticolivestock genetic resourcessingle nucleotide polymorphism markersAnimalseducationGenotypingSelection (genetic algorithm)Multinomial logistic regressionGeneticsPrincipal Component Analysiseducation.field_of_studySheeppenalized multinomial regressionHigh-Throughput Nucleotide SequencingBreedstability selectionAnimal cultureRandom forest030104 developmental biologyPrincipal component analysisAnimal Science and ZoologySettore SECS-S/01 - StatisticaBiomarkers
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Native arbuscular mycorrhizal symbiosis alters foliar bacterial community composition.

2017

The effects of arbuscular mycorrhizal (AM) fungi on plant-associated microbes are poorly known. We tested the hypothesis that colonization by an AM fungus affects microbial species richness and microbial community composition of host plant tissues. We grew the grass, Deschampsia flexuosa in a greenhouse with or without the native AM fungus, Claroideoglomus etunicatum. We divided clonally produced tillers into two parts: one inoculated with AM fungus spores and one without AM fungus inoculation (non-mycorrhizal, NM). We characterized bacterial (16S rRNA gene) and fungal communities (internal transcribed spacer region) in surface-sterilized leaf and root plant compartments. AM fungus inoculat…

0301 basic medicineplant-associated microbesarbuscular mycorrhizal fungiPlant ScienceFungusBiologyPoaceaebakteerit03 medical and health sciencesMycorrhizaeBotanyGeneticsmykorritsasienetColonizationGlomeromycotaSymbiosisMolecular BiologyEcology Evolution Behavior and SystematicsFinland2. Zero hungerBacteriaInoculationMicrobiotafungiBacteroidetesfood and beverageshigh-throughput sequencingGeneral Medicinefoliar nitrogen15. Life on landbiology.organism_classificationSporePlant Leaves030104 developmental biologyMicrobial population biologyDeschampsia flexuosaProteobacteriaMycorrhiza
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A Bimolecular Multicellular Complementation System for the Detection of Syncytium Formation: A New Methodology for the Identification of Nipah Virus …

2019

Fusion of viral and cellular membranes is a key step during the viral life cycle. Enveloped viruses trigger this process by means of specialized viral proteins expressed on their surface, the so-called viral fusion proteins. There are multiple assays to analyze the viral entry including those that focus on the cell-cell fusion induced by some viral proteins. These methods often rely on the identification of multinucleated cells (syncytium) as a result of cell membrane fusions. In this manuscript, we describe a novel methodology for the study of cell-cell fusion. Our approach, named Bimolecular Multicellular Complementation (BiMuC), provides an adjustable platform to qualitatively and quanti…

0301 basic medicinevirusesmembrane fusionlcsh:QR1-502virusNipah virusBiologyGiant Cells01 natural scienceslcsh:MicrobiologySmall Molecule Libraries03 medical and health sciencesVirus entryViral envelopeViral life cycleViral entryVirologyDrug DiscoveryHumansSyncytiumDrug discoveryBrief ReportbiomolèculesHigh-throughput screeningLipid bilayer fusionVirus InternalizationFusion proteinHigh-Throughput Screening Assays0104 chemical sciencesCell biologyBimolecular complementation010404 medicinal & biomolecular chemistryMulticellular organismHEK293 Cells030104 developmental biologyInfectious DiseasesViruses
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Does higher technical efficiency induce a higher service level? A paradox association in the context of port operations

2020

Abstract Researchers and practitioners are benchmarking technical efficiency of ports and exploring the drivers of high efficiency. Paradoxically, this study argues that high technical efficiency (TE = 1) is not always essential, but an optimal level needs to be achieved while balancing the port service level. This study applies data envelopment analysis (DEA) and free disposal hull (FDH) methods to perform efficiency rankings of 38 container terminals from 17 different ports in 12 Asian countries. Four terminals are technically efficient (TE = 1) in all frontier approaches, thereof one Bangladeshi, one Chinese, one Indian and one Vietnamese. Furthermore, this study presents a case study co…

050210 logistics & transportationComputer science05 social sciencesTransportationContext (language use)BenchmarkingManagement Science and Operations ResearchEnvironmental economicsPort (computer networking)VDP::Teknologi: 500Management of Technology and InnovationService level0502 economics and businessQuantitative researchContainer (abstract data type)Data envelopment analysisBusiness and International ManagementThroughput (business)050203 business & managementThe Asian Journal of Shipping and Logistics
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The molecular identification of organic compounds in the atmosphere: state of the art and challenges.

2015

SSCI-VIDE+ATARI:CARE+BNO:BDA; International audience

2-DIMENSIONAL GAS-CHROMATOGRAPHYChemistryCAPILLARY ELECTROPHORESIS/MASS SPECTROMETRYAtmosphereION-CYCLOTRON RESONANCENanotechnologyGeneral Chemistry[CHIM.CATA]Chemical Sciences/CatalysisPERFORMANCE LIQUID-CHROMATOGRAPHY[SDE.ES]Environmental Sciences/Environmental and SocietyHigh-Throughput Screening AssaysAtmospherePOLYCYCLIC AROMATIC-HYDROCARBONSHUMIC-LIKE SUBSTANCESChemistryPULSED-AMPEROMETRIC DETECTIONANION-EXCHANGE CHROMATOGRAPHYEnvironmental chemistryFLIGHT MASS-SPECTROMETRY540 ChemistryOrganic ChemicalsAIRBORNE PARTICULATE MATTERMolecular identificationEnvironmental MonitoringChemical reviews
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Pandemic Spread of COVID-19 Mutant Variants Will Facilitate Next-generation Sequencing Capacities for Personalised Medicine in Urologic Oncology.

2021

2019-20 coronavirus outbreakCoronavirus disease 2019 (COVID-19)business.industrySARS-CoV-2Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)UrologyUrologic OncologyCOVID-19High-Throughput Nucleotide SequencingComputational biologyPrecision medicineMedical OncologyDNA sequencingPandemicMutationResearch LetterMedicineHumansPrecision MedicinebusinessEuropean urology
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Non-convex power allocation games in MIMO cognitive radio networks

2013

Consideramos un escenario de reparto del espectro, basado en la detección, en una red de radio cognitiva MIMO donde el objetivo general es maximizar el rendimiento total de cada usuario de radio cognitiva optimizando conjuntamente la operación de detección y la asignación de potencia en todos los canales, bajo una restricción de interferencia para los usuarios primarios. Los problemas de optimización resultantes conducen a un juego no convexo, que presenta un nuevo desafío a la hora de analizar los equilibrios de este juego. Con el fin de hacer frente a la no convexidad del juego, utilizamos un nuevo concepto relajado de equilibrio, el equilibrio cuasi-Nash (QNE). Se demuestran las condicio…

3G MIMOnon-cooperative gamesComputer Science::Computer Science and Game TheoryMathematical optimization:CIENCIAS TECNOLÓGICAS [UNESCO]021103 operations researchOptimization problemComputer scienceMIMO0211 other engineering and technologies020206 networking & telecommunicationsThroughput02 engineering and technologyUNESCO::CIENCIAS TECNOLÓGICASCognitive radio0202 electrical engineering electronic engineering information engineeringquasi-Nash equilibriumResource allocationGame theoryInterior point methodcognitive radio network
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Genome and phenotype microarray analyses of rhodococcus sp. BCP1 and rhodococcus opacus R7: Genetic determinants and metabolic abilities with environ…

2015

In this paper comparative genome and phenotype microarray analyses of Rhodococcus sp. BCP1 and Rhodococcus opacus R7 were performed. Rhodococcus sp. BCP1 was selected for its ability to grow on short-chain n-alkanes and R. opacus R7 was isolated for its ability to grow on naphthalene and on o-xylene. Results of genome comparison, includ- ing BCP1, R7, along with other Rhodococcus reference strains, showed that at least 30% of the genome of each strain presented unique sequences and only 50% of the predicted proteome was shared. To associate genomic features with metabolic capabilities of BCP1 and R7 strains, hundreds of different growth conditions were tested through Phenotype Microarray, b…

AROMATIC-COMPOUNDS; GENUS RHODOCOCCUS; HIGH-THROUGHPUT; PATHWAY; DEGRADATION; BIODEGRADATION; EQUI; PERFORMANCE; CATABOLISMGenomics RhodococcusGene predictionBacterial Proteinlcsh:MedicineBiologyGenomeXenobioticsRhodococcus opacusBacterial ProteinsRhodococcuslcsh:ScienceGenePhylogenyGeneticsComparative genomicsMultidisciplinarylcsh:RMetabolic Networks and PathwayPhenotype microarrayHigh-Throughput Nucleotide SequencingRhodococcus sp. BCP1 Rhodococcus opacus R7Genome analysisGene Expression Regulation BacterialGenomicsSequence Analysis DNAbiology.organism_classificationBIO/19 - MICROBIOLOGIA GENERALEBiodegradation EnvironmentalPhenotypeProteomeGenomiclcsh:QPhenotype MicroarrayRhodococcusMetabolic Networks and PathwaysRhodococcuhydrocarbon degradationResearch Article
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Binding mode analysis of ABCA7 for the prediction of novel Alzheimer's disease therapeutics

2021

Graphical abstract

ATP Adenosine-triphosphateNBD nucleotide binding domainGSH reduced glutathionePolypharmacologyAlzheimer’s disease (AD)ATP-binding cassette transporterHTS high-throughput screeningBiochemistryABCA7Structural BiologyPLIF protein ligand interactionMSD membrane spanning domainPDB protein data bankTM transmembrane helixABC ATP-binding cassetteMultitarget modulation (PANABC)RMSD root mean square distanceABC transporter (ABCA1 ABCA4 ABCA7)Computer Science ApplicationsMOE Molecular Operating EnvironmentPharmacophoreSNP single-nucleotide polymorphismBiotechnologyResearch ArticleBBB blood-brain barrierBiophysicsDrug designComputational biologyBiologyAD Alzheimer’s diseasePET positron emission tomographyIC intracellular helixAPP amyloid precursor proteincryo-EM cryogenic-electron microscopyGeneticsHomology modelingBinding siteRational drug design and developmentComputingMethodologies_COMPUTERGRAPHICSNBD-cholesterol 7-nitro-2-13-benzoxadiazol-4-yl-cholesterolTransporterPSO particle swarm optimizationPET tracer (PETABC)ECD extracellular domainR-domain/region regulatory domain/regionABCA1biology.proteinEH extracellular helixTP248.13-248.65BODIPY-cholesterol 44-difluoro-4-bora-3a4a-diaza-s-indacene-cholesterolComputational and Structural Biotechnology Journal
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An FPGA-Based Adaptive Fuzzy Coprocessor

2005

The architecture of a general purpose fuzzy logic coprocessor and its implementation on an FPGA based System on Chip is described. Thanks to its ability to support a fast dynamic reconfiguration of all its parameters, it is suitable for implementing adaptive fuzzy logic algorithms, or for the execution of different fuzzy algorithms in a time sharing fashion. The high throughput obtained using a pipelined structure and the efficient data organization allows significant increase of the computational capabilities strongly desired in applications with hard real-time constraints.

Adaptive neuro fuzzy inference systemfuzzy inferenceCoprocessorAdaptive algorithmbusiness.industryComputer scienceMembership functionsControl reconfigurationSettore ING-INF/01 - ElettronicaFuzzy logicFuzzy logicFuzzy electronicsComputer Science::Hardware ArchitectureEmbedded systembusinessThroughput (business)Membership function
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