Search results for "throughput"
showing 10 items of 483 documents
Innovative in Vitro Method To Predict Rate and Extent of Drug Delivery to the Brain across the Blood–Brain Barrier
2013
The relevant parameters for predicting rate and extent of access across the blood-brain barrier (BBB) are fu,plasma (unbound fraction in plasma), Vu,brain (distribution volume in brain) and Kp,uu,brain (ratio of free concentrations in plasma and brain). Their estimation still requires animal studies and in vitro low throughput experiments which make difficult the screening of new CNS candidates. The aim of the present work was to develop a new whole in vitro high throughput method to predict drug rate and extent of access across the BBB. The system permits estimation of fu,plasma, Vu,brain and Kp,uu,brain in a single experimental system, using in vitro cell monolayers in different condition…
Rubinstein–Taybi syndrome 2 with cerebellar abnormality and neural tube defect
2019
Rubinstein-Taybi syndrome (RSTS) is a rare dominant disorder with intellectual disability, postnatal growth deficiency, and multiple congenital anomalies. Approximately 50-70% of the patients have a mutation in the CREBBP gene (RSTS1) and 5-10% display an EP300 gene mutation (RSTS2). Craniospinal abnormalities such as microcranium, scoliosis, and lordosis are frequent findings in RSTS1, but malformations of the brain or spinal cord are seen only occasionally. Here, we report on a 3-year-old boy with facial abnormalities of RSTS, broad thumbs and halluces, developmental delay, autistic features, cerebellar underdevelopment, and a neural tube defect. Molecular diagnostic of the CREBBP and EP3…
Pan-cancer analysis of whole genomes
2020
Publisher's version (útgefin grein)
L'approche basée sur le génotype déterminé par séquençage haut-débit en première intention et le partage international des données pour identifier de…
2019
Developmental disorders (DD) include malformative disorders and neurodevelopmental disorders such as intellectual disability (ID) and autism spectrum disorders (ASD). These clinical features can be isolated or combined in a given patient, they affect around 3% of worldwide population. These disorders are responsible for major morbidity and mortality, for hospitalization especially in pediatric departments, for disabilities and, therefore, this represents a public health priority. Since 2004, in France, several national plans were conducted and extended, the last one being the 3rd National Plan for Rare Disorders (PNMR 2018-2022) which include 10 main goals, among others increasing diagnosis…
Energy Harvesting Powered Packet Transmissions in Duty-Cycled WSNs: A DTMC Analysis
2017
Energy harvesting (EH) promises an extended lifetime for wireless sensor networks (WSNs), supplying sensor nodes with accumulated energy from natural sources. Different from battery powered sensors, nodes in EH-enabled WSNs are equipped with an energy harvesting accessory in order to extract energy from surrounding sources. Based upon the harvested energy, sensor nodes perform data exchange activities. In this paper, we develop two discrete time Markov chain (DTMC) models to analyze the performance of packet transmissions in such a WSN while employing a generic synchronous medium access control (MAC) protocol. Using the proposed DTMC models, we investigate the effect of EH over a specific s…
Frame Based Equipment Medium Access in LTE-U: Mechanism Enhancements and DTMC Modeling
2017
To address the challenge of ever-growing data rate demand and benefit from the popularity of WiFi capability in mobile phones, 3GPP is studying techniques which enable the coexistence of WiFi and LTE in the unlicensed band, known as LTEU. Two flavors of the listen before talk (LBT) principle, referred to as load based equipment (LBE) and frame based equipment (FBE), are recommended by 3GPP. In this paper, we investigate two enhanced FBE mechanisms, i.e., 1) enhanced FBE (E-FBE); and 2) backoff and idle time reduction FBE (BITR-FBE) for the purpose of improving FBE. After presenting the idea of E-FBE, we propose BITR-FBE which can further improve throughput, shorten delay and reduce energy c…
Collision Avoidance in Wake-Up Radio Enabled WSNs: Protocol and Performance Evaluation
2018
In wake-up radio (WuR) enabled wireless sensor networks (WSNs), the envisaged application scenarios are primarily targeted at low traffic load conditions. When applying WuR to medium or heavy traffic load scenarios, however, collisions among wake-up calls (WuCs) may happen, resulting in a lower packet delivery ratio (PDR). In this paper, we propose a media access control protocol for WuR- enabled WSN that is capable of avoiding WuC collisions by activating a contention-based collision avoidance mechanism for WuC transmissions. The performance of the proposed protocol is evaluated by a Markov chain based mathematical model and is compared with a WuR protocol that performs only clear channel as…
Energy Efficient Consecutive Packet Transmissions in Receiver-Initiated Wake-Up Radio Enabled WSNs
2018
In wake-up radio (WuR)-enabled wireless sensor networks, data communication among nodes is triggered in an on-demand manner, by either a sender or a receiver. For receiver-initiated WuR (RI-WuR), a receiving node wakes up sending nodes through a wake-up call. Correspondingly sending nodes transmit packets in a traditional way by competing with one another multiple times in a single operational cycle. In this paper, we propose a receiver-initiated consecutive packet transmission WuR (RI-CPT-WuR) medium access control (MAC) protocol, which eliminates multiple competitions to achieve higher energy efficiency. Furthermore, we develop two associated discrete time Markov chains (DTMCs) for evalua…
Energy resolution and throughput of a new real time digital pulse processing system for x-ray and gamma ray semiconductor detectors
2013
New generation spectroscopy systems have advanced towards digital pulse processing (DPP) approaches. DPP systems, based on direct digitizing and processing of detector signals, have recently been favoured over analog pulse processing electronics, ensuring higher flexibility, stability, lower dead time, higher throughput and better spectroscopic performance. In this work, we present the performance of a new real time DPP system for X-ray and gamma ray semiconductor detectors. The system is based on a commercial digitizer equipped with a custom DPP firmware, developed by our group, for on-line pulse shape and height analysis. X-ray and gamma ray spectra measurements with cadmium telluride (Cd…
Spatial and spectral properties of small area THz generation for sub-wavelength microscopy
2010
A highly localized THz source is a promising candidate for sub-wavelength microscopy, due to its superior radiation power throughput with respect to others near-field techniques. Here, we report on the spatial and the spectral near-field properties of our highly localized THz source.