Search results for "throughput"
showing 10 items of 483 documents
Community Composition, Antifungal Activity and Chemical Analyses of Ant-Derived Actinobacteria
2020
Actinobacteria associated with insects represent one potentially rich source of novel natural products with antifungal activity. Here, we investigated the phylogenetic diversity and community composition of actinobacteria associated with ants using a combination of culture-dependent and -independent methods. Further, we assessed the antagonistic activity against phytopathogenic fungi and identified the secondary metabolites from isolates with bioactivity. A total of 416 actinobacterial isolates were obtained from three ant species (Camponotus japonicus, Lasius fuliginosus, and Lasius flavus) located in five nests. The largest amount of isolates were observed in the head samples. 16S rRNA ge…
A Revised Timescale for Human Evolution Based on Ancient Mitochondrial Genomes
2013
Summary Background Recent analyses of de novo DNA mutations in modern humans have suggested a nuclear substitution rate that is approximately half that of previous estimates based on fossil calibration. This result has led to suggestions that major events in human evolution occurred far earlier than previously thought. Results Here, we use mitochondrial genome sequences from ten securely dated ancient modern humans spanning 40,000 years as calibration points for the mitochondrial clock, thus yielding a direct estimate of the mitochondrial substitution rate. Our clock yields mitochondrial divergence times that are in agreement with earlier estimates based on calibration points derived from e…
A space-division time-division multiple access scheme for high throughput provisioning in WLANs
2005
Directional antennas may dramatically increase the capacity of a Wireless LAN by allowing several stations to simultaneously communicate. Since deployment of directive/smart antennas on the customer's terminals is awkward (for technological, cost, robustness, and convenience reasons) it is of interest to deploy advanced antenna solutions only at the Access Point. When omnidirectional transmissions are used at the Mobile Stations, the asynchronous nature of the 802.11 MAC handshake structurally limits the possibility to exploit spatial reuse. Significant throughput enhancements can be achieved only at the expense of redesigning (part of) the 802.11 MAC protocol: mainly a form of synchronizat…
Learning From Errors: Detecting Cross-Technology Interference in WiFi Networks
2018
In this paper, we show that inter-technology interference can be recognized using commodity WiFi devices by monitoring the statistics of receiver errors. Indeed, while for WiFi standard frames the error probability varies during the frame reception in different frame fields (PHY, MAC headers, and payloads) protected with heterogeneous coding, errors may appear randomly at any point during the time the demodulator is trying to receive an exogenous interfering signal. We thus detect and identify cross-technology interference on off-the-shelf WiFi cards by monitoring the sequence of receiver errors (bad PLCP, bad FCS, invalid headers, etc.) and propose two methods to recognize the source of in…
Novel mutations of the ABCA12, KRT1 and ST14 genes in three unrelated newborns showing congenital ichthyosis.
2022
Abstract Background Congenital ichthyosis (CI) is a heterogeneous group of genetic disorders characterized by generalized dry skin, scaling and hyperkeratosis, often associated to erythroderma. They are rare diseases, with overall incidence of 6.7 in 100,000. Clinical manifestations are due to mutations in genes mostly involved in skin barrier formation. Based on clinical presentation, CI is distinguished in non-syndromic and syndromic forms. To date, mutations of more than 50 genes have been associated to different types of CI. Cases presentation We report on three Italian unrelated newborns showing clinical signs compatible with different forms of CI of variable severity, namely Harlequin…
Drug connectivity mapping and functional analysis reveal therapeutic small molecules that differentially modulate myelination
2022
Disruption or loss of oligodendrocytes (OLs) and myelin has devastating effects on CNS function and integrity, which occur in diverse neurological disorders, including Multiple Sclerosis (MS), Alzheimer’s disease and neuropsychiatric disorders. Hence, there is a need to develop new therapies that promote oligodendrocyte regeneration and myelin repair. A promising approach is drug repurposing, but most agents have potentially contrasting biological actions depending on the cellular context and their dose-dependent effects on intracellular pathways. Here, we have used a combined systems biology and neurobiological approach to identify compounds that exert positive and negative effects on olig…
Development of aDrosophila melanogasterspliceosensor system forin vivohigh-throughput screening in myotonic dystrophy type 1
2014
AbstractAlternative splicing of pre-mRNAs is an important mechanism that regulates cellular function in higher eukaryotes. A growing number of human genetic diseases involve splicing defects that are directly connected to their pathology. In myotonic dystrophy type 1 (DM1), several clinical manifestations have been proposed to be the consequence of tissue-specific missplicing of numerous genes. These events are triggered by an RNA gain-of-function and resultant deregulation of specific RNA-binding factors, such as the nuclear sequestration of muscleblind-like family factors (MBNL1-MBNL3). Thus, the identification of chemical modulators of splicing events could lead to the development of the…
Forecasting container transshipment in Germany
2009
International audience; In this paper, we examine container transshipment at German ports using the seasonal ARIMA (SARIMA) model and the Holt-Winters exponential smoothing approach. Our models are designed especially to take account of the seasonal behavior of the quarterly data used. We consider the dynamic development in this sector for the whole container throughput and also the destinations Asia, Europe and North America, which are the world's three main economic regions. Our data runs from the first quarter of 1989 to the fourth quarter of 2006. We provide detailed quarterly forecasts for the year 2007 and 2008. According to forecasting error measures such as Mean Square Error and The…
Improving the Performance Metric of Wireless Sensor Networks with Clustering Markov Chain Model and Multilevel Fusion
2013
Published version of an article in the journal: Mathematical Problems in Engineering. Also available from the publisher at: http://dx.doi.org/10.1155/2013/783543 Open access The paper proposes a performance metric evaluation for a distributed detection wireless sensor network with respect to IEEE 802.15.4 standard. A distributed detection scheme is considered with presence of the fusion node and organized sensors into the clustering and non-clustering networks. Sensors are distributed in clusters uniformly and nonuniformly and network has multilevel fusion centers. Fusion centers act as heads of clusters for decision making based on majority-like received signal strength (RSS) with comparis…
On the Design of Spontaneous Networks Using a P2P Approach and Bluetooth
2005
In this paper, we address the design of spontaneous networks using a peer to peer (P2P) and Bluetooth technology. A spontaneous network is a small infrastructureless network formed when a group of people come together to participate in some collaborative activity. In this work, we develop a base library and application work ground for easy spontaneous networks development. Based on it, we present an experimental application that provides spontaneous networks with context and transparent services to interchange resources between peers. We describe the overall network architecture and present details of the implementation steps taken to create our P2P and Bluetooth based application. Finally …