Search results for "throughput"
showing 10 items of 483 documents
Liquid Biopsy in Gynecological Cancers
2017
Gynecological cancers originate in woman’s reproductive organs, including ovarian, uterine or endometrial, cervical, vulvar, and vaginal cancers. These tumors are a leading health problem for women accounting for more than 20% of new cases and cancer-related deaths worldwide. Gynecological cancers are characterized by an aggressive biological behavior with a clinical presentation often in advanced stage of disease. This chapter will focus on the potential role of the novel molecular approaches based on liquid biopsy in detecting occult disease, monitoring the progression and identifying treatment-resistance in gynecological cancer patients. The ability to detect circulating tumor DNA (ct-DN…
Joint Power Allocation and Link Selection for Multi-Carrier Buffer Aided Relay Network
2019
In this paper, we present a joint power allocation and adaptive link selection protocol for an orthogonal frequency division multiplexing (OFDM)-based network consists of one source node i.e., base station (BS), one destination node i.e., (MU) and a buffer aided decode and forward (DF) relay node. Our objective is to maximize the average throughput of the system via power loading over different subcarriers at source and relay nodes. A separate power budget is assumed at each transmitting node to make the system more practical. In order to form our solution more tractable, a decomposition framework is implemented to solve the mixed integer optimization problem. Further, less complex suboptim…
Energy efficient resource allocation for secure OFDMA relay systems with eavesdropper
2016
In this paper, we address the energy efficient resource allocation problem for a secure orthogonal frequency division multiple access (OFDMA) relay system. In particular, we consider there is a eavesdropper near the base station (BS) which tries to overtake the information sent by BS. We formulate the joint optimization problem with the objective to optimize the energy efficiency of the considered system by considering subcarrier pairing, secret data rate and power allocation. In addition, the system can assign different priority to different users such that the security of information transmission can be guaranteed. The proposed iterative algorithm not only maximizes the system energy effi…
An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes
2015
Item does not contain fulltext Defects in primary cilium biogenesis underlie the ciliopathies, a growing group of genetic disorders. We describe a whole-genome siRNA-based reverse genetics screen for defects in biogenesis and/or maintenance of the primary cilium, obtaining a global resource. We identify 112 candidate ciliogenesis and ciliopathy genes, including 44 components of the ubiquitin-proteasome system, 12 G-protein-coupled receptors, and 3 pre-mRNA processing factors (PRPF6, PRPF8 and PRPF31) mutated in autosomal dominant retinitis pigmentosa. The PRPFs localize to the connecting cilium, and PRPF8- and PRPF31-mutated cells have ciliary defects. Combining the screen with exome sequen…
Parallel and scalable short-read alignment on multi-core clusters using UPC++
2016
[Abstract]: The growth of next-generation sequencing (NGS) datasets poses a challenge to the alignment of reads to reference genomes in terms of alignment quality and execution speed. Some available aligners have been shown to obtain high quality mappings at the expense of long execution times. Finding fast yet accurate software solutions is of high importance to research, since availability and size of NGS datasets continue to increase. In this work we present an efficient parallelization approach for NGS short-read alignment on multi-core clusters. Our approach takes advantage of a distributed shared memory programming model based on the new UPC++ language. Experimental results using the …
Electroclinical features and outcome of ANKRD11-related KBG syndrome: A novel report and literature review.
2021
KBG syndrome (OMIM #148050) is a rare autosomal dominant disorder, typically characterized by macrodontia of the upper central incisors, distinct craniofacial findings, short stature, and skeletal anomalies associated with neurological involvement including intellectual disability, behaviour difficulties, and epilepsy. KBG syndrome is associated with mutations in ANKRD11 gene that plays a chromatin regulator role of histone acetylation and gene expression during neurogenesis in the embryonic brain.
In vivo phage display: identification of organ-specific peptides using deep sequencing and differential profiling across tissues.
2021
Abstract In vivo phage display is widely used for identification of organ- or disease-specific homing peptides. However, the current in vivo phage biopanning approaches fail to assess biodistribution of specific peptide phages across tissues during the screen, thus necessitating laborious and time-consuming post-screening validation studies on individual peptide phages. Here, we adopted bioinformatics tools used for RNA sequencing for analysis of high-throughput sequencing (HTS) data to estimate the representation of individual peptides during biopanning in vivo. The data from in vivo phage screen were analyzed using differential binding—relative representation of each peptide in the target…
The Multi-frequency Robotic facility REM: first results
2004
The REM Observatory, recently installed and commissioned at la Silla Observatory Chile, is the first moderate aperture robotic telescope able to cover simultaneously the visible-NIR (0.45-2.3 microns) wavelength range. Due to its very fast pointing and its full robotization REM is conceived for fast transients observation. The high throughput Infrared Camera (REMIR) and the Visible imaging spectrograph (ROSS), simultaneously fed by a dichroic, allow to collect high S/N data in an unprecedented large spectral range on a telescope of this size. The REMobservatory is an example of a versatile and agile facility necessary complement to large telescopes in fields in which rapid response and/or t…
High-rate dead-time corrections in a general purpose digital pulse processing system
2015
The abilities on dead-time correction of a real-time digital pulse processing (DPP) system for high-rate high-resolution radiation measurements are presented. The DPP system, through a fast and slow analysis of the output waveform from radiation detectors, is able to perform an accurate estimation of the true input counting rate (ICR), a fine pulse height (energy) and shape (peaking time) analysis even at high ICRs.
In Search of Pathogens: Transcriptome-Based Identification of Viral Sequences from the Pine Processionary Moth (Thaumetopoea pityocampa)
2015
Thaumetopoea pityocampa (pine processionary moth) is one of the most important pine pests in the forests of Mediterranean countries, Central Europe, the Middle East and North Africa. Apart from causing significant damage to pinewoods, T. pityocampa occurrence is also an issue for public and animal health, as it is responsible for dermatological reactions in humans and animals by contact with its irritating hairs. High throughput sequencing technologies have allowed the fast and cost-effective generation of genetic information of interest to understand different biological aspects of non-model organisms as well as the identification of potential pathogens. Using these technologies, we have o…