Search results for "tieteet"
showing 10 items of 379 documents
Didactical Reconstructions in Knowledge Organization and Consolidation in Physics Teacher Education
2020
Physics teachers have an essential role in forming the attitudes and conceptions of future citizens towards science and technology, as well as in educating the future generations of scientists. Therefore, the physics teacher education must guarantee the best available education to pre-service physics teachers; sound knowledge of physics should be combined with a good understanding of the didactical and pedagogical aspects of teaching and learning. The situation is often that after university physics courses, the pre-service physics teachers’ knowledge is still quite fragmented and incoherent. They also often lack the concept formation perspective to physics knowledge. I discuss here a resea…
Proceedings of the 2012 Annual Conference of Finnish Mathematics and Science Education Research Association = Matematiikan ja luonnontieteiden opetuk…
2013
Digital Humanities in the Cultural Environment
2013
Taloustieteellisen tutkimustiedon löydettävyys ja avoimuus Suomessa
2019
Digitalisaatio on alentanut tutkimustiedon etsimiskustannuksia merkittävästi ja mahdollistanut tutkimustiedon tehokkaamman leviämisen. Tästä huolimatta tutkijoiden omat julkaisukäytäntöihin liittyvät valinnat vaikuttavat edelleen tutkimusjulkaisujen löydettävyyteen Internetissä. Tämä katsaus valottaa Suomen yliopistojen taloustieteen professorien tutkimusten julkaisukäytäntöjä ja avoimuutta verkossa. Katsauksen kolme keskeistä havaintoa ovat: 1) Suurin osa professoreista on rekisteröitynyt usealle eri tutkimusjulkaisuja yhteen kokoavalle alustalle: 72 %:lla on ResearchGate-profiili, 67 %:lla IDEAS-profiili ja 58 %:lla Google Scholar Citationsprofiili, 2) professoreiden eniten viitatuista ar…
Koulutuksen tutkimuksen arkkitehtuurit
2018
Development of the Health Promoting Sports Club - National Audit Tool
2022
Abstract Background Sports clubs have requested support from national governing authorities to invest in health promotion (HP), by developing policies, guidelines and dedicated funding. This manuscript outlines the development of a national audit tool to review policies development and implementation to support HP in sports clubs. Methods A 5-step process was undertaken by an international project team: (1) a rapid literature review to identify items assessing policies in physical activity, HP and sports, (2) a thematic analysis to categorize items, (3) a Delphi method to analyze item relevance, country specificity, reformulation, validation and organization, (4) face validity through an on…
Health science student teachers’ perceptions of teacher competence:a qualitative study
2020
Background. Health science teacher competence is multifaceted and continuously changing according to national and international healthcare standards. Organizational restructuring and emphasis on cost effectiveness is changing the scope of health science teachers' practical work and their role in healthcare (worldwide). Aim. This study aimed to describe student teachers' perceptions of the competencies needed to work as an educator in the healthcare field. Objective of study was to gain new knowledge which can be used in the development of teacher education programs in nursing science and to define a broader definition of the health science educators. Methods. A qualitative study was conduct…
Formalin treatment increases the stability and immunogenicity of coxsackievirus B1 VLP vaccine
2019
Type B Coxsackieviruses (CVBs) are a common cause of acute and chronic myocarditis, dilated cardiomyopathy and aseptic meningitis. However, no CVB-vaccines are available for human use. We have previously produced virus-like particles (VLPs) for CVB3 with a baculovirus-insect cell production system. Here we have explored the potential of a VLP-based vaccine targeting CVB1 and describe the production of CVB1-VLPs with a scalable VLP purification method. The developed purification method consisting of tangential flow filtration and ion exchange chromatography is compatible with industrial scale production. CVB1-VLP vaccine was treated with UV-C or formalin to study whether stability and immuno…
Human enterovirus group B viruses rely on vimentin dynamics for efficient processing of viral nonstructural proteins
2020
We report that several viruses from the human enterovirus group B cause massive vimentin rearrangements during lytic infection. Comprehensive studies suggested that viral protein synthesis was triggering the vimentin rearrangements. Blocking the host cell vimentin dynamics with IDPN did not significantly affect the production of progeny viruses and only moderately lowered the synthesis of structural proteins such as VP1. In contrast, the synthesis of the non-structural proteins 2A, 3C, and 3D was drastically lowered. This led to attenuation of the cleavage of the host cell substrates PABP and G3BP1 and reduced caspase activation, thus leading to prolonged cell survival. Furthermore, the loc…
A comparative study of the effect of UV and formalin inactivation on the stability and immunogenicity of a Coxsackievirus B1 vaccine
2019
Type B Coxsackieviruses (CVBs) belong to the enterovirus genus, and they cause both acute and chronic diseases in humans. CVB infections usually lead to flu-like symptoms but can also result in more serious diseases such as myocarditis, aseptic meningitis and life-threatening multi-organ infections in young infants. Thus, CVBs have long been considered as important targets of future vaccines. We have previously observed CVB1 capsid disintegration and virus concentration decrease with 12-day long formalin inactivation protocol. Here a scalable ion exchange chromatography purification method was developed, and purified CVB1 was inactivated with UV-C or formalin. Virus morphology and concentra…