Search results for "tipo"
showing 10 items of 704 documents
Pyramidal and nonpyramidal callosal cells in the striate cortex of the adult rat
1994
The aim of this study has been to determine the neuronal types (pyramidal and nonpyramidal) within the rat's visual cortex, which project through the corpus callosum. To this end, the morphology and laminar distribution of callosal cells have been investigated by combining Diamidino Yellow retrograde tracing with intracellular injection of Lucifer Yellow in slightly fixed tissue slices. The visual callosal projection arises from pyramidal cells of diverse morphology in layers II to VIb, as well as from several modified pyramids located mainly in layers II, IV (star pyramids) and VIb (horizontal or inverted pyramids and related forms of spiny stellate cells). Our results indicate that in rat…
Lucrezio e Carlo Magno. A proposito dell’epistola di Dungal sulle eclissi (MGH Epistolae IV Karolini aevi II, pp. 570-578)
2021
It is generally assumed that Lucretius’ De Rerum Natura disappeared with the end of antiquity and did not reappear until Poggio Bracciolini’s rediscovery (1417). Yet, the oldest and most valuable manuscripts of DRN were copied in the Carolingian age and reflect a high degree of attention to Lucretius’ text and its content. In the present paper, I argue that by studying more carefully the origin and diffusion of Lucretian manuscripts in Carolingian Europe, it is possible to detect an almost unrecognized connection between textual tradition, grammatical erudition, and literary imitatio. In the first section, I offer an overview of the reception of DRN in such representative ninth-century writ…
El patrón oro y el euro. Una reflexión a partir de la lectura de A Tract on Monetary Reform
2017
This paper makes a comparison between the gold standard and the euro through a study of Keynes’s views on the need to manage the macroeconomic situation of an industrial economy. The essay centers on Keynes’s first relevant economic work of the post World War I years, A Tract on Monetary Reform, analyzing its theoretical and practical content. The situation of monetary instability and the choice of exchange regime (to return or not to the gold standard, with the parity prior to the war) were the factors that attracted Keynes’s attention in those years. Similarities between the gold standard and the present euro system bestow a certain interest on Keynes’s ideas and on the economic discussio…
Die mafiaartige organisierte Kriminalität und das italienische Strafrechtssystem
2013
Nach eine Einführung über die Mitwirkung von Recht und Gesellschaft in der italiänischen Einsatz gegen die Mafiartige Kriminalität, wird die ursprünglich ausdrückliche Nichtberücksichtigung des Problems im italienischen Strafgesetzbuch sowie der ersten außer-strafrechtlichen Maßnahmen dargestllt. Dann werden drei Antimafia-Phasen im italienischen Strafrechtssystem zusammengefasst: Eine erste Gruppe von Maßnahmen, die infolge des grundlegenden Gesetzes von 1982 und in den folgenden zehn Jahren in Kraft traten; eine zweite Gruppe von Normen, die nach den Morden an den Richtern Giovanni Falcone und Paolo Borsellino 1992 eingeführt wurden (auch mit Bezugnahme auf den entscheidenden Bereich der …
Real‐world evidence of tisagenlecleucel for the treatment of relapsed or refractory large B‐cell lymphoma
2021
Abstract Tisagenlecleucel (tisa‐cel) is a second‐generation autologous CD19‐targeted chimeric antigen receptor (CAR) T‐cell therapy approved for relapsed/refractory (R/R) large B‐cell lymphoma (LBCL). The approval was based on the results of phase II JULIET trial, with a best overall response rate (ORR) and complete response (CR) rate in infused patients of 52% and 40%, respectively. We report outcomes with tisa‐cel in the standard‐of‐care (SOC) setting for R/R LBCL. Data from all patients with R/R LBCL who underwent leukapheresis from December 2018 until June 2020 with the intent to receive SOC tisa‐cel were retrospectively collected at 10 Spanish institutions. Toxicities were graded accor…
De Novo Mutations in SLC25A24 Cause a Disorder Characterized by Early Aging, Bone Dysplasia, Characteristic Face, and Early Demise
2017
International audience; A series of simplex cases have been reported under various diagnoses sharing early aging, especially evident in congenitally decreased subcutaneous fat tissue and sparse hair, bone dysplasia of the skull and fingers, a distinctive facial gestalt, and prenatal and postnatal growth retardation. For historical reasons, we suggest naming the entity Fontaine syndrome. Exome sequencing of four unrelated affected individuals showed that all carried the de novo missense variant c.649C>T (p.Arg217Cys) or c.650G>A (p.Arg217His) in SLC25A24, a solute carrier 25 family member coding for calcium-binding mitochondrial carrier protein (SCaMC-1, also known as SLC25A24). SLC25A24 all…
Genetic systems for a new approach to risk of progression of diabetic retinopathy.
2016
OBJECTIVE: To evaluate the risk of progression of diabetic retinopathy (DR) using new strategies to obtain genetic information in type 2 diabetes (T2D) based on interfering ribonucleic acid (RNA). MATERIAL AND METHODS: A prospective multicentre case-control study of 132 participants was distributed into: T2D with (+DR) or without (-DR) (T2DG; n=77), and a control group (CG; n=55). After an eye examination and personal interview, tears were collected for molecular analysis (expression of microRNAs [miRNAs] (miRCURY ARN Isolation Kit, Qiagen)]. Libraries, 137 vs. 140bp (GeneMapper, Applied Biosystems), were obtained in 18 samples (T2DG+DR=6; T2DG-DR=6; CG=6) by performing next-generation sequ…
CLOCK gene variation is associated with incidence of type‑2 diabetes and cardiovascular diseases in type‑2 diabetic subjects: dietary modulation in t…
2016
Background: Circadian rhythms regulate key biological processes influencing metabolic pathways. Disregulation is associated with type 2 diabetes (T2D) and cardiovascular diseases (CVD). Circadian rhythms are generated by a transcriptional autoregulatory feedback loop involving core clock genes. CLOCK (circadian locomotor output cycles protein kaput), one of those core genes, is known to regulate glucose metabolism in rodent models. Cross-sectional studies in humans have reported associations between this locus and obesity, plasma glucose, hypertension and T2D prevalence, supporting its role in cardiovascular risk. However, no longitudinal study has investigated the association between CLOCK…
Expression and developmental regulation of the cystine/glutamate exchanger (xc-) in the rat.
2007
The cystine/glutamate exchanger (antiporter x c − ) is a membrane transporter involved in the uptake of cystine, the rate-limiting amino acid in the synthesis of glutathione. Recent studies suggest that the antiporter plays a role in the slow oxidative excitotoxity and in the pathological effects of β-N-oxalylamino-l-alanine, the molecule responsible for neurolathyrism, a neurotoxic upper motor neuron disease. The mouse cystine/glutamate exchanger has been cloned and showed to be composed of two distinct proteins, one of which being a novel protein, named xCT, of 502 amino acids and 12 putative trans-membrane domains. We have generated and purified a polyclonal antibody to mouse xCT and stu…
Common variants of the liver fatty acid binding protein gene influence the risk of type 2 diabetes and insulin resistance in Spanish population.
2012
Journal Article; Research Support, Non-U.S. Gov't; SUMMARY The main objective was to evaluate the association between SNPs and haplotypes of the FABP1-4 genes and type 2 diabetes, as well as its interaction with fat intake, in one general Spanish population. The association was replicated in a second population in which HOMA index was also evaluated. METHODS 1217 unrelated individuals were selected from a population-based study [Hortega study: 605 women; mean age 54 y; 7.8% with type 2 diabetes]. The replication population included 805 subjects from Segovia, a neighboring region of Spain (446 females; mean age 52 y; 10.3% with type 2 diabetes). DM2 mellitus was defined in a similar way in b…