Search results for "tissue engineering."

A Structural Deterministic Model for Electrospun Scaffolds.

2009

Analysis of Electrospun Scaffolds Micro - Architectural Data.

2009

Micro-Meso Scale Models of Electrosun Poly (Ester Urethane) Urea Scaffolds.

2009

Micro - Architectural Data Extraction for Electrospun Poly (Ester Urethane) Urea Scaffolds for Biomechanical Modeling.

2009

Problem: Soft tissue engineered applications have raised the need for accurate descriptions of tissue microstructure and their contributions to global mechanical behavior [1]. Accurate material image analysis is crucial to model engineered tissue biomechanics. The present study proposes a novel method to automatically collect micro-architectural data from electron micrographs (SEM) of electrospun poly (ester urethane) urea (PEUU). Methods: Sets of contiguous SEM images for electrospun PEUU scaffolds made using three mandrel collection tangential velocities (1.5, 4.5, 9.0 m/s) were analyzed. A combination of thresholding and morphological procedures enabled overlaps of fibers to be detected.…

Poly-left-lactic acid tubular scaffolds via diffusion induced phase separation: Control of morphology

2013

n this work, tubular poly-left-lactic acid scaffolds for vascular tissue engineering applications were produced by an innovative two-step method. The scaffolds were obtained by performing a dip-coating around a nylon fiber, followed by a diffusion induced phase separation process. Morphological analysis revealed that the internal lumen of the as-obtained scaffold is equal to the diameter of the fiber utilized; the internal surface is homogeneous with micropores 1–2 μm large. Moreover, a porous open structure was detected across the thickness of the walls of the scaffold. An accurate analysis of the preparation process revealed that it is possible to tune up the morphology of the scaffold (w…

Tubular scaffold for vascular tissue engineering application

2010

A critical obstacle in tissue engineering is the inability to maintain large masses of living cells upon transfer from the in vitro culture conditions into the host in vivo. Capillaries, and the vascular system, are required to supply essential nutrients, including oxygen, remove waste products and provide a biochemical communication “highway”. Another goal in this research field is the possibility to tune the biodegradability of the scaffold. After implantation, the scaffold has to be gradually replaced by cells and extra cellular matrix and it is crucial that this replacement takes place with an appropriate dynamics. A premature degradation, in fact, could lead to a collapse of the struct…

PLLA biodegradable scaffolds for Vascular Tissue Engineering (VTE) applications via dip drawing and Diffusion Induced Phase Separation (DIPS)

2009

Physical and biological properties of electrospun poly(d,l‐lactide)/nanoclay and poly(d,l‐lactide)/nanosilica nanofibrous scaffold for bone tissue en…

2021

Abstract Electrospun scaffolds exhibiting high physical performances with the ability to support cell attachment and proliferation are attracting more and more scientific interest for tissue engineering applications. The inclusion of inorganic nanoparticles such as nanosilica and nanoclay into electrospun biopolymeric matrices can meet these challenging requirements. The silica and clay incorporation into polymeric nanofibers has been reported to enhance and improve the mechanical properties as well as the osteogenic properties of the scaffolds. In this work, for the first time, the physical and biological properties of polylactic acid (PLA) electrospun mats filled with different concentrat…

Poly lactic acid based scaffolds for vascular tissue engineering

2012

A critical obstacle encountered by tissue engineering is the inability to maintain large masses of living cells upon transfer from the in vitro culture conditions to host in vivo. Capillaries, and the vascular system, are required to supply essential nutrients, including oxygen, remove waste products and provide a biochemical communication "highway". The successful use of tissue-engineered constructs is currently limited to thin or avascular tissues, such as skin or cartilage, for which post-implantation neovascularisation from the host is sufficient to meet the demand for oxygen and nutrients. To succeed in the application of tissue engineering for bigger tissues, such as bone or muscle, t…

Polyactide Biodegradable Scaffolds for Tissue Engineering Applications: Phase Separation-Based Techniques

2011

One of the most reliable techniques for the preparation of biodegradable scaffolds suitable for tissue engineering applications (e.g. regeneration of wounded/damaged tissues) is based on liquid/liquid phase separation of ternary solvent/antisolvent/polymer solutions. In particular, two phase separation protocols are examined here: Thermally Induced Phase Separation (TIPS) and Diffusion Induces Phase Separation (DIPS). According to the former protocol, a thermodynamically stable polymeric ternary solution is brought below its metastability/instability point (spinodal/binodal curve) by quench in a cooling medium: under opportune conditions, a foam-like structure is formed by nucleation and 3-…