Search results for "tmax"
showing 9 items of 9 documents
Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo
2021
Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and drug interactions. Here, we reported that three polyoxypregnanes (POPs) as the most abundant constituents of Marsdenia tenacissima (M. tenacissima) were novel ABCB1-modulatory pro-drugs, which underwent intestinal microbiota-mediated biotransformation in vivo to generate active metabolites. The metabolites at non-toxic concentrations restored chemosensitivity in ABCB1-overexpressing cancer cells v…
Multi-layer intrusion detection system with ExtraTrees feature selection, extreme learning machine ensemble, and softmax aggregation
2019
Abstract Recent advances in intrusion detection systems based on machine learning have indeed outperformed other techniques, but struggle with detecting multiple classes of attacks with high accuracy. We propose a method that works in three stages. First, the ExtraTrees classifier is used to select relevant features for each type of attack individually for each (ELM). Then, an ensemble of ELMs is used to detect each type of attack separately. Finally, the results of all ELMs are combined using a softmax layer to refine the results and increase the accuracy further. The intuition behind our system is that multi-class classification is quite difficult compared to binary classification. So, we…
Deep CNN-ELM Hybrid Models for Fire Detection in Images
2018
In this paper, we propose a hybrid model consisting of a Deep Convolutional feature extractor followed by a fast and accurate classifier, the Extreme Learning Machine, for the purpose of fire detection in images. The reason behind using such a model is that Deep CNNs used for image classification take a very long time to train. Even with pre-trained models, the fully connected layers need to be trained with backpropagation, which can be very slow. In contrast, we propose to employ the Extreme Learning Machine (ELM) as the final classifier trained on pre-trained Deep CNN feature extractor. We apply this hybrid model on the problem of fire detection in images. We use state of the art Deep CNN…
Fast Neural Machine Translation Implementation
2018
This paper describes the submissions to the efficiency track for GPUs at the Workshop for Neural Machine Translation and Generation by members of the University of Edinburgh, Adam Mickiewicz University, Tilde and University of Alicante. We focus on efficient implementation of the recurrent deep-learning model as implemented in Amun, the fast inference engine for neural machine translation. We improve the performance with an efficient mini-batching algorithm, and by fusing the softmax operation with the k-best extraction algorithm. Submissions using Amun were first, second and third fastest in the GPU efficiency track.
2021
This paper proposes a new method for blind mesh visual quality assessment (MVQA) based on a graph convolutional network. For that, we address the node classification problem to predict the perceived visual quality. First, two matrices representing the 3D mesh are considered: a graph adjacency matrix and a feature matrix. Both matrices are used as input to a shallow graph convolutional network. The network consists of two convolutional layers followed by a max-pooling layer to provide the final feature representation. With this structure, the Softmax classifier predicts the quality score category without the reference mesh’s availability. Experiments are conducted on four publicly available …
Multimodal biometric recognition systems using deep learning based on the finger vein and finger knuckle print fusion
2020
Recognition systems using multimodal biometrics attracts attention because they improve recognition efficiency and high-security level compared to the unimodal biometrics system. In this study, the authors present a secure multimodal biometrics recognition system based on the deep learning method that uses convolutional neural networks (CNNs). The authors propose two multimodal architectures using the finger knuckle print (FKP) and the finger vein (FV) biometrics with different levels of fusion: the features level fusion and scores level fusion. The features extraction for FKP and FV are performed using transfer learning CNN architectures: AlexNet, VGG16, and ResNet50. The key step aims to …
In vitro evaluation of poloxamer in situ forming gels for bedaquiline fumarate salt and pharmacokinetics following intramuscular injection in rats
2019
Graphical abstract
A Comparative Analysis of Multiple Biasing Techniques for $Q_{biased}$ Softmax Regression Algorithm
2021
Over the past many years the popularity of robotic workers has seen a tremendous surge. Several tasks which were previously considered insurmountable are able to be performed by robots efficiently, with much ease. This is mainly due to the advances made in the field of control systems and artificial intelligence in recent years. Lately, we have seen Reinforcement Learning (RL) capture the spotlight, in the field of robotics. Instead of explicitly specifying the solution of a particular task, RL enables the robot (agent) to explore its environment and through trial and error choose the appropriate response. In this paper, a comparative analysis of biasing techniques for the Q-biased softmax …