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showing 10 items of 14693 documents
Concheros del sur de Iberia en el límite Pleistoceno-Holoceno
2013
El núcleo de yacimientos costeros pleistocenos de la costa de Málaga permite valorar los cambios técnicos y económicos ocurridos en el tránsito Pleistoceno-Holoceno, lo que actualiza una discusión abierta por F. J. Fortea: la relación entre el Magdaleniense y el Epipaleolítico en la región mediterránea ibérica. Estos yacimientos constituyen una documentación decisiva para el conocimiento del uso de los recursos marinos durante el Paleolítico europeo. The concentration of coastal Pleistocene sites along Malaga’s coast allows us to study the technical and economical changes which occurred during the Pleistocene-Holocene transition and thereby to update an open discussion begun by…
Taxonomy and ecology of metazoan parasites of otariids from Patagonia, Argentina : adult and infective stages
2013
At present, the metazoan parasite fauna of most species of otariids is generally poorly known, in part because these marine mammals are mostly protected and, therefore, sampling is limited to specimens stranded on the coast or captured as by-catch in fisheries. Similar problems also occur for the larval stages of gastrointestinal helminths of otariids. For most of these parasite species, the specific identity of the intermediate/paratenic of hosts is unknown and, therefore, many stages of their life cycles remain to be described. Similarly, little is known about the routes of transmission of these parasites between intermediate/paratenic hosts to their otariids definitive hosts. The present…
Prenatal thyroid hormones accelerate postnatal growth and telomere shortening in wild great tits
2021
AbstractEarly-life environment is known to affect later-life health and disease, which could be mediated by the early-life programming of telomere length, a key hallmark of ageing. According to thefetal programming of telomere biology hypothesis, variation in prenatal exposure to hormones is likely to influence telomere length. Yet the contribution of key metabolic hormones,i.e. thyroid hormones (THs), has been largely ignored. We recently showed that in contrast to predictions, exposure to elevated prenatal THs increased postnatal telomere length in wild collared flycatchers, but the generality of such effect, its underlying proximate mechanisms and consequences on survival have not been i…
Repetitive sequence distribution on Saguinus, Leontocebus and Leontopithecus tamarins (Platyrrhine, Primates) by mapping telomeric (TTAGGG) motifs an…
2021
Simple Summary Telomeric and rDNA sequence distribution on tamarins (New world monkeys, Primates) was analysed through molecular cytogenetics by fluorescence in situ hybridization. The mapping of Telomeric and rDNA probes on chromosomes was performed in order to clarify their localization and role in genome evolution. We found rDNA loci on the same homologs 19–22 on the analysed species with a different position in one of them named Leontopithecus rosalia, presumably as result of inversions. Other rDNA signals could be present on chromosome 16 and 17. On the last species, we found the classic telomeric sequence with exceptions while on the other species analysed, we found very amplified tel…
L'architetto e l'aristocrazia
2013
Il saggio intende dare un contributo alla conoscenza dell'architetto Rosario Gagliardi a partire dal suo rapporto con la committenza nelle città del Val di Noto
Construction des territoires et choix des aristocraties normandes entre la France et l'Angleterre (1204-1258)
2007
National audience; Dans la première moitié du XIIIe siècle, "l'empire normand" disparaît ; la territorialité de cette entité qui reposait avant tout sur un réseau relationnel est brisée. En imposant à l'aristocratie anglo-normande un choix exclusif entre le continent et l'Angleterre, Philippe Auguste recompose le paysage nobiliaire de part et d'autre de la Manche et contribue à un processus de construction des territoires qui avait commencé bien avant la scission.
Feasibility of conductive embroidered threads for I 2 C sensors in microcontroller-based wearable electronics
2023
Abstract In recent years, the importance of flexible and textile electronics in the field of wearable devices has continuously increased, as they are expected to replace conventional wires that exhibit limited resistance to the mechanical stress occurring in on-body applications. Wearable health devices (WHDs) can provide physiological information about various body parts and employ distributed sensor networks. Among the sensors typically integrated within WHDs, those based on the I2C communication protocol are very common and exploit signals transmitted at frequencies up to hundreds of kilohertz. Therefore, robust communication is required to guarantee a proper transmission of the signal a…
Heat Shock Protein 60 in Hepatocellular Carcinoma: Insights and Perspectives
2020
Heat shock protein 60 (HSP60) is a mitochondrial chaperone that is implicated in physiological and pathological processes. For instance, it contributes to protein folding and stability, translocation of mitochondrial proteins, and apoptosis. Variations in the expression levels of HSP60 have been correlated to various diseases and cancers, including hepatocellular carcinoma (HCC). Unlike other HSPs which clearly increase in some cancers, data about HSP60 levels in HCC are controversial and difficult to interpret. In the current review, we summarize and simplify the current knowledge about the role of HSP60 in HCC. In addition, we highlight the possibility of its targeting, using chemical com…
Response to the Letter to the editor regarding “Targeting NUPR1 with the small compound ZZW-115 is an efficient strategy to treat hepatocellular carc…
2021
How important is the role of iterative liver direct surgery in patients with hepatocellular carcinoma for a transplant center located in an area with…
2022
IntroductionHepatocellular carcinoma (HCC) accounts for nearly 90% of primary liver cancers, with estimates of over 1 million people affected by 2025. We aimed to explore the impacting role of an iterative surgical treatment approach in a cohort of HCC patients within the Milan criteria, associated with clinical risk factors for tumor recurrence (RHCC) after liver transplant (LT) and loco-regional therapies (LRT), as well as liver resection (LR) and/or microwave thermal ablation (MWTA).MethodsWe retrospectively analyzed our experience performed during an 8-year period between January 2013 and December 2021 in patients treated for HCC, focusing on describing the impact on preoperative end-st…