Search results for "tolerance"
showing 10 items of 956 documents
Effect of QVA149 on lung volumes and exercise tolerance in COPD patients: The BRIGHT study
2014
Summary Introduction QVA149 is a novel, inhaled, once-daily dual bronchodilator containing a fixed-dose combination of the long-acting β 2 -agonist indacaterol and the long-acting muscarinic antagonist glycopyrronium (NVA237), for the treatment of chronic obstructive pulmonary disease (COPD). This study evaluated the effects of QVA149 on exercise tolerance, hyperinflation, lung function and lung volumes versus placebo and tiotropium. Methods Patients with moderate-to-severe COPD were randomized to QVA149 110/50 μg, placebo or tiotropium 18 μg once daily in a blinded, 3-period crossover study for 3 weeks. The primary endpoint was exercise endurance time at Day 21 for QVA149 versus placebo. R…
New Immunohistologic Findings on the Differential Role of Cyclooxygenase 1 and Cyclooxygenase 2 in Nasal Polyposis
2005
Background Cyclooxygenase 1 (Cox-1) plays a key role in arachidonic acid metabolism and in the pathophysiology and immunology of nasal polyposis in patients suffering from aspirin intolerance. We hypothesize that Cox-2 also might be relevant in the etiology of nasal polyps of aspirin-tolerant patients by their effects on inflammatory mediators as well as on microvascular permeability. Methods Fifty-two surgical specimens were immunohistochemically labeled for Cox-1 and Cox-2. Specimens were taken from chronically inflamed mucosa (n = 19) and from nasal polyps (n = 19) during endonasal sinus surgery. Controls were obtained from healthy nasal respiratory mucosa (n = 14), harvested during turb…
Early life body mass trajectories and mortality in older age: Findings from the Helsinki Birth Cohort Study
2014
Overweight and obesity in childhood have been linked to an increased risk of adult mortality, but evidence is still scarce.We identified trajectories of body mass index (BMI) development in early life and investigated their mortality risk. Data come from the Helsinki Birth Cohort Study, in which 4943 individuals, born 1934-1944, had serial measures of weight and height from birth to 11 years extracted from health care records, weight and height data in adulthood, and register-based mortality data for 2000-2010.Three early BMI trajectories (increasing, average, and average-to-low for men and increasing, average, and low-to-high BMI for women) were identified. Women with an increasing or low-…
Is sense of coherence a predictor of lifestyle changes in subjects at risk for type 2 diabetes?
2015
Objective: To determine whether the sense of coherence (SOC) could predict the outcome of an 18-month lifestyle intervention program for subjects at risk of type 2 diabetes. Methods: Subjects at high risk of type 2 diabetes mellitus were recruited to a low-intensity lifestyle intervention program by their general practitioners. Weight reduction ≥5% and improvement in exercise capacity of ≥10% from baseline to follow-up indicated a clinically significant lifestyle change. SOC was measured using the 13-item SOC questionnaire. Results: The study involved 213 subjects with a mean body mass index of 37 (SD ± 6). Complete follow-up data were obtained for 131 (62%). Twenty-six participants had cli…
Night-Time Shift Work and Related Stress Responses: A Study on Security Guards
2020
Work-related stress can induce a break in homeostasis by placing demands on the body that are met by the activation of two different systems, the hypothalamic&ndash
A phase II/III clinical study of enzyme replacement therapy with idursulfase in mucopolysaccharidosis II (Hunter syndrome)
2006
Purpose: To evaluate the safety and efficacy of recombinant human iduronate-2-sulfatase (idursulfase) in the treatment of mucopolysaccharidosis II. Methods: Ninety-six mucopolysaccharidosis II patients between 5 and 31 years of age were enrolled in a double-blind, placebo-controlled trial. Patients were randomized to placebo infusions, weekly idursulfase (0.5 mg/kg) infusions or every-other-week infusions of idursulfase (0.5 mg/kg). Efficacy was evaluated using a composite endpoint consisting of distance walked in 6 minutes and the percentage of predicted forced vital capacity based on the sum of the ranks of change from baseline. Results: Patients in the weekly and every-other-week idursul…
Combined effects of shiftwork and individual working time control on long-term sickness absence: a prospective study of finnish employees
2014
Objective To investigate whether the effects of shiftwork on long-term sickness absence vary according to the level of individual working time control (WTC). Methods A representative sample of Finnish employees (1447 men and 1624 women) was combined with a register-based follow-up. A negative binomial model was used in the analysis of long-term sickness absence days. The results were adjusted for various background and work-related factors. Results Individual WTC decreased long-term sickness absence. The higher rate of sickness absences in shiftwork was mainly due to the lower level of WTC. Working time control decreased sickness absence equally in day work and shiftwork. Conclusions The ne…
The relationship between age and fitness profiles in elite male ice hockey players
2021
Background: The present study investigated relationships between age, body composition and performance in elite male ice hockey players.Methods: 199 players performed off-ice tests (countermovement jump height (CMJ) and body composition) and on-ice tests (5-10-5 Pro Agility test, 30-m sprint test and the maximal Yo-Yo Intermittent Recovery Ice Hockey test (Yo-Yo IR1-IHMAX) for assessment of aerobic capacity.Results: No overall correlations between age and performance were present except small-moderate positive associations between age and body-and muscle mass (r=0.24-0.30, ≤0.05). The youngest age group (YOU; 18-21 years) were 4-9% lighter than all other age groups and possessed 7% less mus…
Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: evaluation of …
1999
Aims/hypothesis. The aim of this study was to screen part of the putative promoter sequence in addition to 14 potential phosphotyrosine residues of human IRS-2 for genetic variability which might cause changes in protein expression or function. Furthermore, the potential impact on insulin secretion and sensitivity of a previously identified IRS-2 variant (Gly1057Asp) was analysed Methods. The screenings were carried out by the SSCP-heteroduplex technique on DNA from Type II (non-insulin-dependent) diabetic patients. The impact of the Gly1057Asp variant was analysed in four glucose-tolerant Scandinavian study groups. Results. The results showed no nucleotide substitutions in the promoter seq…
Reliability of different models to assess heart rate recovery after submaximal bicycle exercise.
2011
Abstract Objectives : Different models to assess HR recovery have been developed but knowledge of their reliability is poor at different submaximal exercise intensities and recovery durations. Our aim was to determine the reliability of HR recovery after a test on a cycle ergometer. Design : Twenty-one healthy individuals performed a submaximal exercise at 65% and 80% HR max followed by passive recovery. The exercise was repeated (retest) within 2 weeks to assess reliability. Method : HR recovery was assessed by 8 models, based on monoexponential kinetics or absolute recovery (recovered HR at fix time points). Intraclass correlation coefficient (ICC) and standard error of measurement (SEM, …