Search results for "tolerance"
showing 10 items of 956 documents
On the potential of NoC virtualization for multicore chips
2008
As the end of Moores-law is on the horizon, power becomes a limiting factor to continuous increases in performance gains for single-core processors. Processor engineers have shifted to the multicore paradigm and many-core processors are a reality. Within the context of these multi-core chips, three key metrics point themselves out as being of major importance, performance, fault-tolerance (including yield), and power consumption. A solution that optimizes all three of these metrics is challenging. As the number of cores increases the importance of the interconnection network-on-chip (NoC) grows as well, and chip designers should aim to optimize these three key metrics in the NoC context as …
Regulatory T Cells and IL-10 Independently Counterregulate Cytotoxic T Lymphocyte Responses Induced by Transcutaneous Immunization
2011
Background: The imidazoquinoline derivate imiquimod induces inflammatory responses and protection against transplanted tumors when applied to the skin in combination with a cognate peptide epitope (transcutaneous immunization, TCI). Here we investigated the role of regulatory T cells (Treg) and the suppressive cytokine IL-10 in restricting TCI-induced cytotoxic T lymphocyte (CTL) responses. Methodology/Principal Findings: TCI was performed with an ointment containing the TLR7 agonist imiquimod and a CTL epitope was applied to the depilated back skin of C57BL/6 mice. Using specific antibodies and FoxP3-diphteria toxin receptor transgenic (DEREG) mice, we interrogated inhibiting factors after…
Soil loss tolerance in the context of the European Green Deal
2023
Soil erosion by water, and the consequent loss of a non-renewable resource, is a relevant environmental issue which has economic, ecologic, and social repercussions. In the context of the European Green Deal, the increasing awareness of soil Ecosystem Services is leading to give the due relevance to this problem. Notwithstanding the recent soil conservation strategies adopted by the Common Agricultural Policy had positive effects, the concern regarding this topic is drastically increasing for the normalization of extraordinary rainfall events due to climate change. Recent events occurred in Europe demonstrated that landscape protection is often inadequate and interventions to prevent damage…
Multiple Sclerosis: Focus on Extracellular and Artificial Vesicles, Nanoparticles as Potential Therapeutic Approaches
2021
Multiple sclerosis (MS) is an autoimmune disease of the Central Nervous System, characterized by an inflammatory process leading to the destruction of myelin with neuronal death and neurodegeneration. In MS, lymphocytes cross the blood-brain barrier, creating inflammatory demyelinated plaques located primarily in the white matter. MS potential treatments involve various mechanisms of action on immune cells, immunosuppression, inhibition of the passage through the blood-brain barrier, and immunotolerance. Bio-nanotechnology represents a promising approach to improve the treatment of autoimmune diseases by its ability to affect the immune responses. The use of nanotechnology has been actively…
Virally Infected Mouse Liver Endothelial Cells Trigger CD8+ T-Cell Immunity
2009
Background & Aims Dendritic cell activation through ligation of pattern recognition receptors leading to full functional maturation causes induction of CD8 + T-cell immunity through increased delivery of costimulatory signals instead of tolerance. Here we investigate whether organ-resident antigen-presenting cells, such as liver sinusoidal endothelial cells (LSECs), also switch from tolerogenic to immunogenic CD8 + T-cell activation upon such stimulation. Methods Murine LSECs were isolated by immunomagnetic separation and analyzed for functional maturation upon triggering pattern recognition receptors or viral infection employing gene expression analysis and T cell coculture assays. In vivo…
Myeloid dendritic cell: From sentinel of immunity to key player of peripheral tolerance?
2009
Myeloid dendritic cells (DC) are "sentinels" of immunity, ideally positioned throughout the body gateways and equipped with unique properties to transport antigens from the periphery to lymphoid tissues. They are professional antigen-presenting cells transmitting incoming infectious signals to T cells, the key players of adaptive immunity. For induction of effective antigen-specific T-cell immunity, crosstalk of DC and naive T cells is mandatory. However, besides this essential immunostimulatory function of DC, consolidated findings from the DC research field in the last 10 years have shown that DC have an additional important function. They act as pivotal players in the peripheral toleranc…
Friend retrovirus infection of myeloid dendritic cells impairs maturation, prolongs contact to naïve T cells, and favors expansion of regulatory T ce…
2007
AbstractRetroviruses have developed immunmodulatory mechanisms to avoid being attacked by the immune system. The mechanisms of this retrovirus-associated immune suppression are far from clarified. Dendritic cells (DCs) have been attributed a decisive role in these pathogenic processes. We have used the Friend retrovirus (FV) mouse model in order to acquire further knowledge about the role of infection of DCs in virus-induced immunosuppression. About 20% of the myeloid DCs that were generated from the bone marrow of FV-infected mice carried FV proteins. The infection was productive, and infected DCs transmitted the virus in cell culture and in vivo. FV infection of DCs led to a defect in DC …
Piekrastes sugu Plantago maritima un Plantago coronopus sālsizturības un jonu uzkrāšanās salīdzinājums
2021
Pētījuma mērķis bija veģetācijas eksperimentā kontrolētos apstākļos salīdzināt divu jūras piekrastei specifisku ceļteku sugu (Plantago coronopus un jūrmalas ceļteka) izturību pret pieaugošām NaCl koncentrācijām un jonu uzkrāšanās īpatnības. Augus audzēja automatizētās siltumnīcas apstākļos veģetācijas traukos. Abu ceļteku sugu augus apstrādāja ar pieaugošas Na+ koncentrācijas devu, katrā variantā bija pieci atkārtojumi. Eksperimenta beigās augu sadalīja morfoloģiski atsevišķās daļās, noteica to svaigo un sauso masu, ūdens satura, kā arī mērija Na+ un K+ jonu koncentrāciju, elektrovadītspēju un osmotisko aktivitāti. Abas ceļteku sugas spēja augt un vairoties jūras ūdens sāļuma apstākļos. Pla…
IL-10 Controls Ultraviolet-Induced Carcinogenesis in Mice
2007
Abstract UV radiation-induced immunosuppression contributes significantly to the development of UV-induced skin cancer by inhibiting protective immune responses. IL-10 has been shown to be a key mediator of UV-induced immunosuppression. To investigate the role of IL-10 during photocarcinogenesis, groups of IL-10+/+, IL-10+/−, and IL-10−/− mice were chronically irradiated with UV. IL-10+/+ and IL-10+/− mice developed skin cancer to similar extents, whereas IL-10−/− mice were protected against the induction of skin malignancies by UV. Because UV is able to induce regulatory T cells, which play a role in the suppression of protective immunity, UV-induced regulatory T cell function was analyzed…
Randomized Comparative Trial with Ceftizoxime and Cefotaxime in Urinary Tract Infections
1984
Ceftizoxime, a new, semisynthetic, beta-lactamase-resistant cephalosporin, is not metabolized in man and is excreted almost entirely as the original active compound in the urine. The efficacy and safety of ceftizoxime were assessed in 80 patients with acute and chronic urinary infections, with and without associated pathological conditions, in comparison with cefotaxime. Two dosage schedules, 1 g or 0.5 g every 12 h, i.v. or i.m. for 10 days, were adopted according to the severity of each case and to separate randomization tables for each schedule; causal agents were all sensitive to both drugs in vitro. The overall results were excellent. Safety was excellent in almost all cases. In this t…