Search results for "tolerance"

Clinical heterogeneity in infantile galactosialidosis

1987

A new case of infantile galactosialidosis is presented. The condition was diagnosed when the patient was 4 months of age and she died at 20 months. She exhibited some of the symptoms of classical infantile galactosialidosis but no corneal clouding, cherry-red macular spot or limitation of joint mobility. Sonographic examination showed large kidneys and thickened cardiac septa, two symptoms as yet undescribed in this disorder. Urinary oligosaccharide analysis gave grossly pathological results and subsequent fibroblast enzyme analysis showed a deficiency of alpha-neuraminidase and beta-galactosidase. The patient's clinical features are compared with the few cases so far described in the liter…

Immunomodulation in vascularized composite allotransplantation: What is the role for adipose-derived stem cells?

2019

Hand and face transplants are becoming increasingly common, recording progressively more penile, uterus, abdominal wall, and allotransplantation cases reported worldwide. Despite current protocols allow long-term survival of the allografts, the ultimate goal of donor-specific tolerance has not been achieved yet. In fact, the harmful adverse effects related to the lifelong administration of immunosuppressive agents are the main drawbacks for vascularized composite allotransplantations. Research is very active in investigating alternative methods to induce greater tolerance while minimizing toxicity. Adipose-derived stem cells (ASCs) represent promising cell therapies for immunomodulation in …

Caurviju prasmju veicināšana mācību tēmas "uzturs" apguvē mājturībā un tehnoloģijās 9.klasē

2019

Diplomdarba mērķis ir izveidot kompetenču pieejā balstītu mācību saturu tēmai “Uzturs” un aprobēt to mājturībā un tehnoloģijās 9.klasē. Darbā ir apkopots mācību saturs par tēmu “Uzturs” 9. klasē. Tēmas ietvaros informācija par diētām, dažādiem mīklas izstrādājumiem, “Slowfood”, galda kultūru , latviešu gadskārtu svinībām un ēdieniem. Darba ietvaros izveidots tematiskais plāns, izmantojot projekta “Kompetenču pieeja mācību saturā”, ko īsteno Valsts izglītības satura centrs, mācību pieeju – attīstīt caurviju prasmes, kas ietver sevī četrus prasmju kopumus – pašizziņa un pašvadība, domāšana un radošums, sadarbība un līdzdalība un digitālā prasmes. Diplomdarba noslēgumā autore apraksta skolēnu …

Public responses to intimate partner violence against women: the influence of perceived severity and personal responsibility.

2009

This paper explored public willingness to act when exposed to cases of intimate partner violence against women, by analyzing the influence of perceived severity and personal responsibility on two types of responses: mediating and reporting to the police. Results (N = 419) yielded main effects of personal responsibility for both types of responses. No main effects of perceived severity were found. A significant interaction between perceived severity and personal responsibility was found only for reporting responses. Results are discussed in light of the helping behavior research tradition. Implications for public education and advocacy programs are also considered. Marisol.lila@uv.es; Enriqu…

A randomized controlled trial protocol for persistent physical symptoms associated with indoor environment or chronic fatigue : Effectiveness of vide…

2023

IntroductionPersistent physical symptoms (PPS) refer to symptoms that cannot be fully explained by structural bodily pathology or by environmental factors. Their impact on daily functioning varies from mild to severe disability. So far, evidence-based treatments for PPS have resulted in only small to moderate effects. Treatment protocols with a stronger orientation toward personalized approaches are needed to improve the efficacy and applicability of treatment. In this study, we aim to assess the effect of an online individual case conceptualization with web-based program for PPS. This study is conducted among two focus groups: patients with indoor air-related symptoms and patients with chr…

A new class of organic nitrates: investigations on bioactivation, tolerance and cross-tolerance phenomena

2009

Background and purpose:  The chronic use of organic nitrates is limited by serious side effects including oxidative stress, nitrate tolerance and/or endothelial dysfunction. The side effects and potency of nitroglycerine depend on mitochondrial aldehyde dehydrogenase (ALDH-2). We sought to determine whether this concept can be extended to a new class of organic nitrates with amino moieties (aminoalkyl nitrates). Experimental approach:  Vasodilator potency of the organic nitrates, in vitro tolerance and in vivo tolerance (after continuous infusion for 3 days) were assessed in wild-type and ALDH-2 knockout mice by isometric tension studies. Mitochondrial oxidative stress was analysed by L-012…

Anti-oxidative effects in response to pentaerithrityl tetranitrate (PETN) treatment are mediated by heme oxygenase-1 and ferritin induction and preve…

2006

Gene amplification in fibroblasts from ataxia telangiectasia (AT) patients and in X-ray hypersensitive AT-like Chinese hamster mutants.

2001

In search of functions involved in the regulation of gene amplification, and given the relevance of chromosome breakage in initiating the process, we analyzed the gene amplification ability of cells hypersensitive to inducers of DNA double-strand breaks and defective in cell cycle control: two human fibroblast strains derived from patients affected by ataxia telangiectasia (AT) and two hamster mutant cell lines belonging to complementation group XRCC8 of the rodent X-ray-sensitive mutants. These mutants are considered hamster models of AT cells. To measure gene amplification, the frequency and the rate of occurrence of N-(phosphonacetyl)-L-aspartate resistant cells were determined. In both …

The working day in medicine: lessons from the air.

2003

This article discusses whether it would be wrong to explain a mistake involving medical responsibility on the basis of an opinion that the professional was not in the optimum physical or mental state at the moment the mistake took place.

The response ofAsterochloris erici(Ahmadjian) Skaloud et Peksa to desiccation: a proteomic approach

2013

The study of desiccation tolerance of lichens, and of their chlorobionts in particular, has frequently focused on the anti- oxidant system that protects the cell against photo-oxidative stress during dehydration/rehydration cycles. In this study, we used proteomic and transcript analyses to assess the changes associated with desiccation in the isolated phycobiont Aste- rochloris erici. Algae were dried either slowly (5-6 h) or rapidly (<60 min), and rehydrated after 24 h in the desiccated state. To identify proteins that accumulated during the drying or rehydration processes, we employed two-dimensional (2D) difference gel electrophoresis (DIGE) coupled with individual protein identificatio…