Search results for "tomography"

Neuroimaging for the anesthesiologist.

2007

Neuroimaging is essential in the treatment of cerebral nervous system disorders or in patients in the ICU with deterioration of their neurologic function. Leading clinical symptoms are acute neurologic deficits with different stages of hemisymptomatology, primary or progressing loss of consciousness or vigilance deficit, focal or generalized seizures, sometimes combined with an acute respiratory or circulatory insufficiency. The resulting questions can be summarized in those of intracranial space occupying hemorrhage; acute infarction; and signs for reduced cerebral blood flow, cerebrovascular vasospasm, or intracranial mass. Recent evolutions in imaging have contributed to an increase in d…

Design of Bimodal Ligands of Neurotensin Receptor 1 for Positron Emission Tomography Imaging and Fluorescence-Guided Surgery of Pancreatic Cancer

2020

International audience; Neurotensin receptor 1 (NTSR1) is overexpressed in most human pancreatic ductal adenocarcinomas. It makes it an attractive target for the development of pancreatic cancer imaging agents. In this study, we sought to develop a bimodal PET-fluorescent imaging agent capable of specifically targeting these receptors. Starting from the structure of a known NTSR1 agonist, a series of tracers was synthesized, radiometalated with gallium-68 and evaluated in vitro and in vivo, in mice bearing an AsPC-1 xenograft. PET imaging allowed us to identify the compound [ 68 Ga]Ga-NODAGA-Lys(Cy5**)-AEEAc-[Me-Arg 8 , Tle 12 ]-NT(7-13) as the one with the most promising biodistribution pr…

Neutron tomography of ancient lead artefacts

2014

Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively. The investigations presented here show the results of an epigraphic analysis on ancient Roman lead ingots rescued from shipwrecks along the coast of Sicily (Italy) by means of Neutron Tomography (NT). The artefacts, including a lead horn, can be dated back to a period between the 3rd and 1st century BC. The three dimensional NT reconstructions helped the decipherment of hidden s…

Spectrum of non-cardiac collateral findings in patients with suspected coronary artery disease assessed with Multislice Computed Tomography Coronary …

2009

Supercontinuum optimization for dual-soliton based light sources using genetic algorithms in a grid platform

2014

We present a numerical strategy to design fiber based dual pulse light sources exhibiting two predefined spectral peaks in the anomalous group velocity dispersion regime. The frequency conversion is based on the soliton fission and soliton self-frequency shift occurring during super- continuum generation. The optimization process is carried out by a genetic algorithm that provides the optimum input pulse parameters: wavelength, temporal width and peak power. This algorithm is implemented in a Grid platform in order to take advantage of distributed computing. These results are useful for optical coherence tomography applications where bell-shaped pulses located in the second near-infrared wi…

Geodynamic inversion to constrain the non-linear rheology of the lithosphere

2015

A common method to determine the strength of the lithosphere is through estimating its effective elastic thickness from the coherence between gravity and topography. This method assumes a priori that the lithosphere is a thin elastic plate floating on a viscous mantle. Whereas this seems to work well with oceanic plates, it has given controversial results in continental collision zones. Usually, continental collisions zones are well-studied areas for which additional geophysical datasets such as receiver functions and seismic tomography exist that constrain the geometry of the lithosphere and often show that it is rather complex. Yet, lithospheric geometry by itself is insufficient to under…

640-Slice CT Measurement of Superior Orbital Fissure as Gateway for Light into the Brain: Statistical Evaluation of Area and Distance.

2016

Objective Our aim was to provide normative data concerning superior orbital fissure area (SOFA), ocular skin and the substantia nigra (D-SS) and orbital fissure and the substantia nigra (D-SOF-S) distances by CT scan in adult Caucasian population. Methods The area of the superior orbital fissure (SOF), the distance between the ocular skin and the substantia nigra and the distance between the superior orbital fissure and the substantia nigra using CT and 3D-CT images. Results Normative data stratified for age and gender were obtained. The data here reported show that some degree of variability in SOFA, D-SS and D-SOF-S measurements can be observed healthy Caucasian subjects. Gender stratifie…

Spatial Reconstruction Algorithm of DT Layer in Cryogenic Targets Using Optical Techniques

2007

The measurements of the solid DT layer, in terms of thickness and roughness, in the LMJ geometry (i.e. in a hohlraum) are not trivial. The DT layer measurements will be done using a Matsukov-Cassegrain telescope placed 39 cm away from the target. This telescope will be used to acquire shadowgraphy images on equators, and interferometric measurements on pole areas using optical coherence tomography (OCT). Optical coherence tomography allows determining the DT layer thickness on a few points, in the polar regions of the target. By scanning around the poles, several points can be acquired in order to calculate the roughness and the local shape of the DT layer at the pole. Both techniques were …

Neutron tomography for archaeological investigations

2006

Within the last decade neutron tomography and radiography significantly gained importance. Especially its application in non-destructive testing for industrial components can be underlined. A good example is the automotive and aviation industry, where a high contrast for the used lubricants and adhesive materials is required. In contrast to X-rays, neutrons are able to penetrate thick layers of metals and provide on the other hand a high sensitivity to hydrogen containing materials. In recent years, a large number of applications in other fields like biology, medicine, geology and especially archaeology have been reported. Here the potential of neutron tomography for investigations on archa…

The measuring method for tests of horizontal two-phase gas–liquid flows, using optical and capacitance tomography

2009

Abstract The paper presents a measurement method in testing horizontal two-phase gas–liquid flows. It also describes the test stand including two tomography measurement systems. The optical and capacitance tomography systems can be used for measurements at the same time. It is necessary to apply two tomography systems working at the same time because of complexity of phenomena occurring in two-phase flows, and a wide range of applicability of the presented method. The optical tomography system in which a tested object is illuminated from five projections. The measurement of luminous intensity is changed into a discrete signal (0 or 1) in the detectors including 64 optical sensors. Next, the…