Search results for "tonus"
showing 10 items of 24 documents
Effect of segmental muscle vibration on upper extremity functional ability poststroke: A randomized controlled trial.
2019
Abstract Background: Upper extremity functional impairments are common consequences of stroke. Therefore, continuous investigation of effective interventions for upper extremity functions after stroke is a necessity. Segmental muscle vibration (SMV) is one of the interventions that incorporate sensory stimulation to improve motor cortical excitability. The aim of this study was to investigate the influence of 5-minute SMV application along with supervised physical therapy (SPT) on improving activities of daily living and motor recovery on the hemiparetic upper extremity in patients with stroke. Methods: A sample of 37 patients poststroke (29 males) was randomly allocated to either SPT contr…
Effect of segmental muscle vibration on upper extremity functional ability poststroke
2019
Abstract Background: Upper extremity functional impairments are common consequences of stroke. Therefore, continuous investigation of effective interventions for upper extremity functions after stroke is a necessity. Segmental muscle vibration (SMV) is one of the interventions that incorporate sensory stimulation to improve motor cortical excitability. The aim of this study was to investigate the influence of 5-minute SMV application along with supervised physical therapy (SPT) on improving activities of daily living and motor recovery on the hemiparetic upper extremity in patients with stroke. Methods: A sample of 37 patients poststroke (29 males) was randomly allocated to either SPT contr…
A useful muscarinic parameter and the differential recording of atrial and ventricular tension in the perfused rabbit heart
1971
1. A simple method of recording right atrial tension from the Langendorff perfused rabbit has been described; it is based on the “transverse” method of recording cardiac contractions described by Beckett (1970). 2. Right atrial and ventricular tensions were recorded by transducers attached to threads stitched into the right atrium and right ventricle, the heart being retained and prevented from rotating by two threads stitched into the intraventricular septum as described by Beckett. 3. Right ventricular diastolic tension was adjusted to 7.5 g. Interference with the atrial record by ventricular systole was overcome by adjustment of diastolic right atrial tension to its optimal value between…
The effects of LSD in the guinea-pig ileum
1985
The effects of lysergic acid diethylamide (LSD) on acetylcholine release and on smooth muscle tone were studied in the myenteric plexus-longitudinal muscle preparation of the guinea pig. LSD (0.01-10 microM) depressed in a concentration-dependent manner the electrically-evoked [3H]-acetylcholine outflow from strips preincubated with [3H]-choline. The maximal effect was a 45% inhibition by 1 microM LSD. The spontaneous outflow was not affected. Metitepine competitively antagonized (pA2 8.0) the LSD-induced reduction of the evoked outflow. Tolazoline and mepyramine did not affect the inhibitory action of LSD. The contractions in response to electrical stimulation were enhanced by 34% in the p…
Comparative study of taurine and tauropyrone: GABA receptor binding, mitochondrial processes and behaviour.
2011
Abstract Objectives Taurine, a sulfur-containing amino acid, has high hydrophilicity and is poorly absorbed. Tauropyrone, a taurine-containing 1,4-dihydropyridine derivative, is suggested to have greater activity than taurine owing to improved physicochemical properties that facilitate delivery of the compound to target cells. The aim of this study was to determine whether the 1,4-dihydropyridine moiety in tauropyrone improves the pharmacological efficacy of taurine in vitro and in vivo. Methods The effects of taurine and tauropyrone, as well as of the 1,4-dihydropyridine moiety were compared in in-vitro experiments to determine the binding to GABA receptors and influence on mitochondrial p…
Functional evidence for different roles of GABAA and GABAB receptors in modulating mouse gastric tone
2010
Abstract The aims of the present study were to investigate, using mouse whole stomach in vitro , the effects of γ-aminobutyric acid (GABA) and GABA receptor agonists on the spontaneous gastric tone, to examine the subtypes of GABA receptors involved in the responses and to determine the possible site(s) of action. GABA induced gastric relaxation, which was antagonized by the GABA A -receptor antagonist, bicuculline, potentiated by phaclofen, GABA B -receptor antagonist, but not affected by 1,2,5,6-Tetrahydropyridin-4-yl methylphosphinic acid hydrate (TPMPA), GABA C -receptor antagonist. Muscimol, GABA A -receptor agonist, mimicked GABA effects inducing relaxation, which was significantly re…
Betulin binds to gamma-aminobutyric acid receptors and exerts anticonvulsant action in mice.
2007
The lupane type pentacyclic triterpenes: lupeol, betulin, and betulinic acid are widely distributed natural compounds. Recently, pharmaceutical compositions from plant extracts (family Marcgraviaceae) containing betulinic acid, have been patented as anxiolytic remedies. To extend our knowledge of the CNS effects of the triterpenes, we suggest here that the chemically related lupeol, betulin and betulinic acid may interact with the brain neurotransmitter gamma-aminobutyric acid (GABA) receptors in vitro and in vivo. Using radioligand receptor-binding assay, we showed that only betulin bound to the GABA(A)-receptor sites in mice brain in vitro and antagonised the GABA(A)-receptor antagonist b…
565 Reflection on a Case of Dopamine-Responsive Dystonia
2012
Background Characteristic symptoms of Dopamine-responsive dystonia (DRD) are increased muscle tone and Parkinsonian features. Children with DRD are often misdiagnosed. The disorder responds well to treatment with Levodopa. Aim To reflect on a case of DRD. Method Case report of a 13 years old girl misdiagnosed with tetany. Results The girl was hospitalized for opisthotonus, positive Trousseau and Chvostek signs, diagnosed as tetany. The laboratory analysis have shown: normal serum of calcium (2.28 mmol/l), normal serum of magnesium (0.80 mmol/l), normal serum of phosphor (1.26 mmol/l), normal alkaline phosphatase (261 u/l) and normal PTH (27.9 pg/ml). Although the initial evolution was favor…
SPEEK membrānu hidratācijas – dehidratācijas pētījumi
2015
SPEEK membrānu hidratācijas-dehidratācijas pētījumi. Sala, E., zinātniskais vadītājs Dr. ķīm., pētnieks Veldre, K. Bakalaura darbs, 45 lappuses, 30 attēli, 7 tabulas, 56 literatūras avoti. Latviešu valodā. Darbā ir veikti dažādu SPEEK membrānu ūdens satura pētījumi, izmantojot termogravimetriju un diferenciāli termisko analīzi. Pētītas SPEEK membrānu sastāva un fizikālo īpašību izmaiņas dažādos gaisa relatīvos mirumos. Ar infrasarkano spektrometriju, pulvera rentgendifraktometriju un viļņu disperso rentgenfluorescenses spektrometriju pārbaudīts membrānu sastāvs. SPEEK membrānām uzņemtas hidratācijas līknes un apskatīti piemērotākie cietās fāzes kinētiskie modeļi. Darbs izstrādāts Latvijas U…
Hypertrofisen kuormituksen akuutit vaikutukset lihastonukseen
2008
Mälkiä, Sampo. 2008. Hypertrofisen kuormituksen akuutit vaikutukset lihastonukseen. Valmennus- ja testausopin kandidaatintutkielma. Jyväskylän yliopisto. Liikuntabiologian laitos. 46 sivua. Aikaisemmat lihastonukseen liittyvät tutkimukset ovat keskittyneet kliinisiin tutkimuksiin eri potilasryhmillä. Tämän tutkimuksen tarkoituksena oli selvittää tapahtuuko lihastonuksessa muutosta raskaan hypertrofisen kuormituksen seurauksena. Tutkimukseen osallistui 24 miespuolista koehenkilöä (ikä 26.0 ± 4.3 v, pituus 181.3 ± 6.4 cm, paino 78.4 ± 8.0 kg). Koehenkilöt jaettiin satunnaisesti kahteen ryhmään siten, että toinen ryhmistä (n=15) suoritti hypertrofisen kuormituksen, toisen (n=9) toimiessa kontr…